P36776 | LONM_HUMAN | Lon protease homolog, mitochondrial (LONP1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00004 | AAA - ATPase family associated with various cellular activities (AAA) | 519~656 | |
| PF02190 | LON_substr_bdg - ATP-dependent protease La (LON) substrate-binding domain | 124~368 | |
| PF05362 | Lon_C - Lon protease (S16) C-terminal proteolytic domain | 737~947 | |
| PF22667 | Lon_lid - Lon protease AAA+ ATPase lid domain | 682~733 |
3D structures mapped by conservation among orthologs
[ Domain: "Ribosomal protein S5 domain 2-like" // Lon_C_N ]
[ Domain: "C-terminal subdomain in Lon-related proteases catalytic domains" // Lon_C_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4876525 |  |
IC50 | = | 17.0 | nM | 398.27 | CCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CCCc1ccccc1)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4856865 |  |
IC50 | = | 18.0 | nM | 446.32 | O=C(N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCc1ccccc1)B(O)O)c1cnccn1 | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4864108 |  |
IC50 | = | 34.0 | nM | 432.29 | O=C(N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)B(O)O)c1cnccn1 | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4877126 |  |
IC50 | = | 38.0 | nM | 336.2 | CCCC[C@H](NC(=O)[C@@H](CCC)NC(=O)c1cnccn1)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4870013 |  |
IC50 | = | 59.0 | nM | 415.3 | CCC[C@@H](NC(=O)c1oc(C)nc1C)C(=O)N[C@@H](CCCc1ccccc1)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4862424 |  |
IC50 | = | 65.0 | nM | 412.3 | CC(C)CCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4870902 |  |
IC50 | = | 77.0 | nM | 477.17 | O=C(N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCCBr)B(O)O)c1cnccn1 | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4876920 |  |
IC50 | = | 92.0 | nM | 384.25 | CCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CCc1ccccc1)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4850612 |  |
IC50 | = | 92.0 | nM | 424.31 | O=C(N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC1CCCCC1)B(O)O)c1cnccn1 | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4856768 |  |
IC50 | = | 93.0 | nM | 350.23 | CCCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CC(C)C)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4847335 |  |
IC50 | = | 109.0 | nM | 418.26 | O=C(N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)B(O)O)c1cnccn1 | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4863384 |  |
IC50 | = | 136.0 | nM | 376.27 | CCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CC1CCCCC1)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4847763 |  |
IC50 | = | 137.0 | nM | 390.29 | CC(C)C[C@H](NC(=O)[C@@H](CC1CCCCC1)NC(=O)c1cnccn1)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL325041 |  |
IC50 | = | 183.0 | nM | 384.25 | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4861871 |  |
IC50 | = | 187.0 | nM | 336.2 | CCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CC(C)C)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4858320 |  |
IC50 | = | 253.0 | nM | 384.25 | CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4853599 |  |
IC50 | = | 408.0 | nM | 322.17 | CC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](CC(C)C)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4864045 |  |
IC50 | = | 433.0 | nM | 308.15 | CC(C)C[C@H](NC(=O)[C@@H](C)NC(=O)c1cnccn1)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4859172 |  |
IC50 | = | 546.0 | nM | 336.2 | CC(C)C[C@H](NC(=O)[C@H](NC(=O)c1cnccn1)C(C)C)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |
| CHEMBL4850826 |  |
IC50 | = | 556.0 | nM | 370.22 | CCC[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](Cc1ccccc1)B(O)O | Homo sapiens | CHEMBL4823871 | single protein format |