P36639 | 8ODP_HUMAN | Oxidized purine nucleoside triphosphate hydrolase (NUDT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00293 | NUDIX - NUDIX domain | 7~126 |
3D structures mapped by conservation among orthologs
[ Domain: "Nudix" // NUDIX_1 ]
[ Domain: "Nudix" // NUDIX ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4436749 |  |
IC50 | = | 0.043 | nM | 295.39 | CC(=O)Nc1cc2c(c(-c3cccc(C)c3C)n1)CCCN2 | Homo sapiens | CHEMBL4345255 | assay format |
| CHEMBL4468099 |  |
IC50 | < | 0.05 | nM | 310.4 | CNC(=O)Nc1cc2c(c(-c3cccc(C)c3C)n1)CCCN2 | Homo sapiens | CHEMBL4345255 | assay format |
| CHEMBL4451394 |  |
IC50 | < | 0.05 | nM | 335.45 | Cc1cccc(-c2nc(NC(=O)C3CCC3)cc3c2CCCN3)c1C | Homo sapiens | CHEMBL4345255 | assay format |
| CHEMBL4455353 |  |
IC50 | < | 0.05 | nM | 296.37 | Cc1cccc(-c2nc(NC(N)=O)cc3c2CCCN3)c1C | Homo sapiens | CHEMBL4345255 | assay format |
| CHEMBL4570266 |  |
IC50 | = | 0.06 | nM | 321.42 | Cc1cccc(-c2nc(NC(=O)C3CC3)cc3c2CCCN3)c1C | Homo sapiens | CHEMBL4345255 | assay format |
| CHEMBL4778773 |  |
IC50 | = | 0.08 | nM | 435.53 | CNC(=O)c1cnc2cc(OC)c(OCN3CCN(C)CC3)cc2c1Nc1ccccc1 | Homo sapiens | CHEMBL4673830 | single protein format |
| CHEMBL4064004 |  |
IC50 | < | 0.1 | nM | 335.41 | CCNC(=O)c1cc2c(N3CCCC3c3cccnc3)ccnc2[nH]1 | Homo sapiens | CHEMBL4037917 | single protein format |
| CHEMBL4070624 |  |
IC50 | = | 0.1 | nM | 314.39 | CCNC(=O)c1cc2c(N3CCOCC3C3CC3)ccnc2[nH]1 | Homo sapiens | CHEMBL4037917 | single protein format |
| CHEMBL4083992 |  |
IC50 | = | 0.1 | nM | 363.42 | O=C(NC1COC1)c1cc2c(N3CCCC3c3cccnc3)ccnc2[nH]1 | Homo sapiens | CHEMBL4037917 | single protein format |
| CHEMBL4101983 |  |
IC50 | < | 0.1 | nM | 335.41 | CCNC(=O)c1cc2c(N3CCCC3c3ccccn3)ccnc2[nH]1 | Homo sapiens | CHEMBL4037917 | single protein format |
| CHEMBL4073623 |  |
IC50 | < | 0.1 | nM | 347.42 | O=C(NC1CC1)c1cc2c(N3CCCC3c3ccccn3)ccnc2[nH]1 | Homo sapiens | CHEMBL4037917 | single protein format |
| CHEMBL4094252 |  |
IC50 | < | 0.1 | nM | 363.42 | O=C(NC1COC1)c1cc2c(N3CCCC3c3ccccn3)ccnc2[nH]1 | Homo sapiens | CHEMBL4037917 | single protein format |
| CHEMBL4067896 |  |
IC50 | < | 0.1 | nM | 330.43 | CCNC(=O)c1cc2c(N3CCCC3C(C)(C)OC)ccnc2[nH]1 | Homo sapiens | CHEMBL4037917 | single protein format |
| CHEMBL4078783 |  |
IC50 | < | 0.1 | nM | 350.42 | CCNC(=O)c1cc2c(N3CCOCC3c3ccccc3)ccnc2[nH]1 | Homo sapiens | CHEMBL4037917 | single protein format |
| CHEMBL4091768 |  |
IC50 | < | 0.1 | nM | 334.42 | CCNC(=O)c1cc2c(N3CCCC3c3ccccc3)ccnc2[nH]1 | Homo sapiens | CHEMBL4037917 | single protein format |
| CHEMBL4460228 |  |
IC50 | = | 0.11 | nM | 331.37 | Cc1cccc(-c2nc(NC(=O)C(F)F)cc3c2CCCN3)c1C | Homo sapiens | CHEMBL4345255 | assay format |
| CHEMBL4435945 |  |
IC50 | = | 0.15 | nM | 311.39 | COC(=O)Nc1cc2c(c(-c3cccc(C)c3C)n1)CCCN2 | Homo sapiens | CHEMBL4345255 | assay format |
| CHEMBL4529335 |  |
IC50 | = | 0.17 | nM | 309.41 | CCC(=O)Nc1cc2c(c(-c3cccc(C)c3C)n1)CCCN2 | Homo sapiens | CHEMBL4345255 | assay format |
| CHEMBL3781661 |  |
IC50 | = | 0.2 | nM | 195.27 | Cc1cnc(N)nc1OCC(C)(C)C | Homo sapiens | CHEMBL3782136 | single protein format |
| CHEMBL3780962 |  |
IC50 | = | 0.2 | nM | 208.31 | Cc1cnc(N)nc1N(C)CC(C)(C)C | Homo sapiens | CHEMBL3782136 | single protein format |