P36544 | ACHA7_HUMAN | Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02931 | Neur_chan_LBD - Neurotransmitter-gated ion-channel ligand binding domain | 27~230 | |
| PF02932 | Neur_chan_memb - Neurotransmitter-gated ion-channel transmembrane region | 237~486 |
3D structures mapped by conservation among orthologs
[ Domain: "Nicotinic receptor ligand binding domain-like" // Neur_chan_LBD ]
[ Domain: "Neurotransmitter-gated ion-channel transmembrane pore" // Neur_chan_memb ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5201239 |  |
IC50 | = | 1.48 | nM | 421.32 | C[N+]1(C)CC[C@H](Oc2ccc(/C=C/c3ccccc3)cc2)C1.[I-] | Homo sapiens | CHEMBL5136918 | cell-based format |
| CHEMBL5178473 |  |
IC50 | = | 1.49 | nM | 421.32 | C[N+]1(C)CC[C@@H](Oc2ccc(/C=C/c3ccccc3)cc2)C1.[I-] | Homo sapiens | CHEMBL5136918 | cell-based format |
| CHEMBL5190813 |  |
IC50 | = | 2.04 | nM | 435.35 | C[N+]1(CCOc2ccc(/C=C/c3ccccc3)cc2)CCCC1.[I-] | Homo sapiens | CHEMBL5136918 | cell-based format |
| CHEMBL5176101 |  |
IC50 | = | 2.29 | nM | 449.38 | C[N+]1(CCOc2ccc(/C=C/c3ccccc3)cc2)CCCCC1.[I-] | Homo sapiens | CHEMBL5136918 | cell-based format |
| CHEMBL5174508 |  |
IC50 | = | 2.45 | nM | 421.32 | C[N+]1(CCOc2ccc(/C=C/c3ccccc3)cc2)CCC1.[I-] | Homo sapiens | CHEMBL5136918 | cell-based format |
| CHEMBL5177606 |  |
IC50 | = | 2.75 | nM | 461.39 | C(=C/c1ccc(OCC[N+]23CCC(CC2)CC3)cc1)\c1ccccc1.[I-] | Homo sapiens | CHEMBL5136918 | cell-based format |
| CHEMBL3302240 |  |
IC50 | = | 6.0 | nM | 311.35 | c1cncc(OC[C@H]2CNCCN2c2nc3ncccc3o2)c1 | Homo sapiens | CHEMBL3810515 | single protein format |
| CHEMBL4291079 |  |
IC50 | = | 6.5 | nM | 479.45 | CC[N+](CC)(CC)CCCCOc1ccc(/C=C/c2ccccc2)cc1.[I-] | Homo sapiens | CHEMBL4265356 | assay format |
| CHEMBL3302229 |  |
IC50 | = | 11.0 | nM | 342.4 | COc1ccc(NC(=O)N2CCNCC2COc2cccnc2)cc1 | Homo sapiens | CHEMBL3810515 | single protein format |
| CHEMBL4293646 |  |
IC50 | = | 12.3 | nM | 507.5 | CC[N+](CC)(CC)CCCCCCOc1ccc(/C=C/c2ccccc2)cc1.[I-] | Homo sapiens | CHEMBL4265356 | assay format |
| CHEMBL3303977 |  |
IC50 | = | 19.0 | nM | 342.4 | COc1ccc(NC(=O)N2CCNC[C@@H]2COc2cccnc2)cc1 | Homo sapiens | CHEMBL3810515 | single protein format |
| CHEMBL4453847 |  |
IC50 | = | 21.25 | nM | 319.41 | O=C(N[C@H]1CN2CCC1CC2)c1cc2ccc3ccccc3n2c1 | Homo sapiens | CHEMBL4408507 | cell-based format |
| CHEMBL4280452 |  |
IC50 | = | 24.3 | nM | 539.5 | CC[N+](CC)(CC)CCCCOc1ccc(/C=C/c2cc(OC)cc(OC)c2)cc1.[I-] | Homo sapiens | CHEMBL4265356 | assay format |
| CHEMBL6623 |  |
IC50 | = | 31.0 | nM | 208.69 | Clc1ccc(C2CC3CCC2N3)cn1 | Homo sapiens | CHEMBL3076136 | cell-based format |
| CHEMBL1257065 |  |
IC50 | = | 41.0 | nM | 451.39 | CC[N+](CC)(CC)CCOc1ccc(/C=C/c2ccccc2)cc1.[I-] | Homo sapiens | CHEMBL4265356 | assay format |
| CHEMBL4287656 |  |
IC50 | = | 47.0 | nM | 511.44 | CC[N+](CC)(CC)CCOc1ccc(/C=C/c2cc(OC)cc(OC)c2)cc1.[I-] | Homo sapiens | CHEMBL4265356 | assay format |
| CHEMBL5176690 |  |
IC50 | = | 78.2 | nM | 407.3 | C[N+]1(C)CC(Oc2ccc(/C=C/c3ccccc3)cc2)C1.[I-] | Homo sapiens | CHEMBL5136918 | cell-based format |
| CHEMBL4285772 |  |
IC50 | = | 92.0 | nM | 535.55 | CC[N+](CC)(CC)CCCCCCCCOc1ccc(/C=C/c2ccccc2)cc1.[I-] | Homo sapiens | CHEMBL4265356 | assay format |
| CHEMBL191491 |  |
IC50 | = | 110.0 | nM | 324.49 | CC[N+](CC)(CC)CCOc1ccc(/C=C/c2ccccc2)cc1 | Homo sapiens | CHEMBL831106 | single protein format |
| CHEMBL1890808 |  |
IC50 | = | 200.0 | nM | 187.29 | c1ccc(C2CN3CCC2CC3)cc1 | Homo sapiens | CHEMBL2148894 | cell-based format |