P35968 | VGFR2_HUMAN | Vascular endothelial growth factor receptor 2 (KDR)

Pfam Domain Table

AccessionDomainRangeColor
PF00047ig - Immunoglobulin domain234~310
PF07679I-set - Immunoglobulin I-set domain340~410
PF07679I-set - Immunoglobulin I-set domain667~751
PF07714PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase834~1160
PF13895Ig_2 - Immunoglobulin domain551~661
PF17988VEGFR-2_TMD - VEGFR-2 Transmembrane domain759~793
PF21339VEGFR-1-like_Ig-like - Vascular endothelial growth factor receptor 1-like, Ig-like domain133~217
PF22854VEGFR1-3_N_Ig-like - VEGFR1-3, N-terminal Ig-like domain21~130
PF22971Ig_VEGFR-1-like_5th - VEGFR-1-like, immunoglobulin-like domain432~548

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // C1-set_3 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // IG_like ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_13 ]

 PyMOL session

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set ]

 PyMOL session

[ Domain: "Protein kinase" // Pkinase_Tyr ]

 PyMOL session

[ Domain: "Transmembrane segment of lysosome-associated membrane glycoprotein 2" // UNK_F_TYPE ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5189340 IC50 = 0.023 nM 473.96 CN(C)c1ccc(/C=N/NC(=O)Cn2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)cc1 Homo sapiens CHEMBL5104376 single protein format
CHEMBL429743 IC50 = 0.03 nM 484.94 COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(Cl)cc5)cccc4c3)c2cc1OC Homo sapiens CHEMBL950174 single protein format
CHEMBL5186748 IC50 = 0.12 nM 489.92 CNC(=O)c1cc(Oc2ccc(NC(=O)c3nn(-c4ccc(Cl)cc4)cc(C)c3=O)cc2)ccn1 Homo sapiens CHEMBL5104356 single protein format
CHEMBL3093581 IC50 = 0.14 nM 523.52 O=C(Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1cccn(-c2ccccc2)c1=O Homo sapiens CHEMBL3094546 assay format
CHEMBL3586072 IC50 = 0.14 nM 493.28 CNC(=O)c1ccc(-c2ccc(NC(=O)Nc3cc(Br)cc(C(F)(F)F)c3)cc2)cn1 Homo sapiens CHEMBL3587278 single protein format
CHEMBL3586071 IC50 = 0.15 nM 448.83 CNC(=O)c1cc(-c2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 Homo sapiens CHEMBL3587278 single protein format
CHEMBL1289494 IC50 = 0.16 nM 454.87 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC Homo sapiens CHEMBL1292980 single protein format
CHEMBL5403470 IC50 = 0.19 nM 580.06 COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(C)c(F)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 Homo sapiens CHEMBL5328005 single protein format
CHEMBL2348996 IC50 = 0.19 nM 431.46 Cc1cc(C(=O)Nc2cccc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)c2)n(C)n1 Homo sapiens CHEMBL2353609 single protein format
CHEMBL5399711 IC50 = 0.19 nM 382.42 COc1cc(-c2cc(-c3ccc4ccccc4c3)nc(NN)c2C#N)ccc1O Homo sapiens CHEMBL5380326 single protein format
CHEMBL426047 IC50 = 0.2 nM 445.48 COc1ccccc1NC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1 Homo sapiens CHEMBL876146 single protein format
CHEMBL411630 IC50 = 0.2 nM 471.51 COc1cc2nccc(Oc3ccc4c(c3)OCCN4C(=O)Nc3ccc(C)cc3)c2cc1OC Homo sapiens CHEMBL950174 single protein format
CHEMBL369760 IC50 = 0.2 nM 429.48 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3)c2cc1OC Homo sapiens CHEMBL876146 single protein format
CHEMBL272824 IC50 = 0.2 nM 450.49 COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccccc5)cccc4c3)c2cc1OC Homo sapiens CHEMBL932834 single protein format
CHEMBL409538 IC50 = 0.2 nM 441.44 COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccon5)cccc4c3)c2cc1OC Homo sapiens CHEMBL932834 single protein format
CHEMBL368252 IC50 = 0.2 nM 415.45 COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC Homo sapiens CHEMBL876146 single protein format
CHEMBL409512 IC50 = 0.2 nM 497.94 COc1cc2nccc(Oc3ccc4c(C(=O)Nc5ccc(Cl)cc5)cccc4c3)c2cc1C(N)=O Homo sapiens CHEMBL932834 single protein format
CHEMBL179165 IC50 = 0.2 nM 449.89 COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)c2cc1OC Homo sapiens CHEMBL876146 single protein format
CHEMBL3939307 IC50 = 0.2 nM 388.5 CNC(=O)c1ccccc1Sc1ccc2c(CCc3ccccn3)n[nH]c2c1 Homo sapiens CHEMBL3871602 single protein format
CHEMBL3586057 IC50 = 0.22 nM 425.33 O=C(Nc1ccc(-c2cccnc2)cc1)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1 Homo sapiens CHEMBL3587278 single protein format