P35916 | VGFR3_HUMAN | Vascular endothelial growth factor receptor 3 (FLT4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF07679 | I-set - Immunoglobulin I-set domain | 678~765 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 845~1169 | |
| PF13927 | Ig_3 - Immunoglobulin domain | 236~314 | |
| PF17988 | VEGFR-2_TMD - VEGFR-2 Transmembrane domain | 770~804 | |
| PF21339 | VEGFR-1-like_Ig-like - Vascular endothelial growth factor receptor 1-like, Ig-like domain | 146~223 | |
| PF22854 | VEGFR1-3_N_Ig-like - VEGFR1-3, N-terminal Ig-like domain | 23~141 | |
| PF22971 | Ig_VEGFR-1-like_5th - VEGFR-1-like, immunoglobulin-like domain | 421~553 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_4 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // IG_like ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_13 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_13,I-set ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1289926 |  |
IC50 | = | 0.1 | nM | 386.48 | CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 | Homo sapiens | CHEMBL4271315 | single protein format |
| CHEMBL3939307 |  |
IC50 | = | 0.1 | nM | 388.5 | CNC(=O)c1ccccc1Sc1ccc2c(CCc3ccccn3)n[nH]c2c1 | Homo sapiens | CHEMBL3871603 | single protein format |
| CHEMBL5403470 |  |
IC50 | = | 0.18 | nM | 580.06 | COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(C)c(F)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5328006 | single protein format |
| CHEMBL1940109 |  |
IC50 | = | 0.2 | nM | 479.49 | COCCOc1cc2ncnc(Oc3cnn(CC(=O)Nc4cccc(OC)c4)c3)c2cc1OC | Homo sapiens | CHEMBL1942930 | cell-based format |
| CHEMBL1289494 |  |
IC50 | = | 0.24 | nM | 454.87 | COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC | Homo sapiens | CHEMBL2186467 | single protein format |
| CHEMBL5412144 |  |
IC50 | = | 0.38 | nM | 580.09 | COc1cc2c(Oc3ccc(NC(=O)Nc4cnn(C(C)C)c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5328006 | single protein format |
| CHEMBL5410264 |  |
IC50 | = | 0.39 | nM | 562.07 | COc1cc2c(Oc3ccc(NC(=O)Nc4ccc(C)cc4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5328006 | single protein format |
| CHEMBL1940108 |  |
IC50 | = | 0.4 | nM | 435.44 | COc1cccc(NC(=O)Cn2cc(Oc3ncnc4cc(OC)c(OC)cc34)cn2)c1 | Homo sapiens | CHEMBL1942930 | cell-based format |
| CHEMBL5421149 |  |
IC50 | = | 0.43 | nM | 563.63 | COc1cc2c(Oc3ccc(NC(=O)Nc4cnn(C(C)C)c4)c(F)c3)ncnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5328006 | single protein format |
| CHEMBL1668411 |  |
IC50 | = | 0.5 | nM | 362.38 | COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O | Homo sapiens | CHEMBL1670830 | single protein format |
| CHEMBL5436823 |  |
IC50 | = | 0.54 | nM | 528.05 | CCCCNC(=O)Nc1ccc(Oc2ncnc3cc(OCCCN4CCCC4)c(OC)cc23)cc1Cl | Homo sapiens | CHEMBL5328006 | single protein format |
| CHEMBL5393865 |  |
IC50 | = | 0.58 | nM | 580.06 | COc1cc2c(Oc3ccc(NC(=O)Nc4cc(C)ccc4F)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5328006 | single protein format |
| CHEMBL1173411 |  |
IC50 | = | 0.8 | nM | 432.44 | COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]cc(C(=O)O)c2C)cc1 | Homo sapiens | CHEMBL1176707 | single protein format |
| CHEMBL5403747 |  |
IC50 | = | 0.8 | nM | 588.06 | COc1cc2c(Oc3ccc(NC(=O)Nc4ccc5occc5c4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5328006 | single protein format |
| CHEMBL5176837 |  |
IC50 | = | 1.0 | nM | 389.46 | COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 | Homo sapiens | CHEMBL5150851 | single protein format |
| CHEMBL495727 |  |
IC50 | = | 1.0 | nM | 381.44 | O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 | Homo sapiens | CHEMBL1009877 | single protein format |
| CHEMBL3891581 |  |
IC50 | = | 1.0 | nM | 491.04 | CN1CCC(c2ccc(Nc3ncc(Cl)c(CCc4ccccc4C4(C(N)=O)CC4)n3)cn2)CC1 | Homo sapiens | CHEMBL3887860 | single protein format |
| CHEMBL5408069 |  |
IC50 | = | 1.03 | nM | 562.07 | COc1cc2c(Oc3ccc(NC(=O)NCc4ccccc4)c(Cl)c3)ncnc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL5328006 | single protein format |
| CHEMBL2180604 |  |
IC50 | = | 1.1 | nM | 445.48 | Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1 | Homo sapiens | CHEMBL2186467 | single protein format |
| CHEMBL4453304 |  |
IC50 | = | 1.1 | nM | 398.41 | COc1cc(O)c2c(c1)-c1cccc(c1)[C@@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O | Homo sapiens | CHEMBL4337766 | single protein format |