P35790 | CHKA_HUMAN | Choline kinase alpha (CHKA)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01633 | Choline_kinase - Choline/ethanolamine kinase | 114~449 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Fructosamin_kin ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5094847 |  |
IC50 | = | 14.0 | nM | 489.05 | CC1(C)Cc2nc(NC(=O)[C@H]3CC[C@@H](n4cnc5c(N)nc(Cl)nc54)CC3)sc2C(C)(C)N1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5091519 |  |
IC50 | = | 14.0 | nM | 509.47 | Cl.Nc1nc(Cl)nc2c1ncn2[C@H]1CC[C@@H](C(=O)Nc2nc3c(s2)CN(C2CC2)CC3)CC1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL3765554 |  |
IC50 | = | 20.0 | nM | 421.58 | O[C@](CCc1ccccc1OC1CCOCC1)(c1ccccc1)C1CN2CCC1CC2 | Homo sapiens | CHEMBL3766475 | single protein format |
| CHEMBL5078600 |  |
IC50 | = | 20.0 | nM | 433.93 | Nc1nc(Cl)nc2c1ncn2[C@H]1CC[C@@H](C(=O)Nc2nc3c(s2)COCC3)CC1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5079663 |  |
IC50 | = | 20.0 | nM | 484.97 | NC(=O)Cc1ccc2nc(NC(=O)[C@H]3CC[C@@H](n4cnc5c(N)nc(Cl)nc54)CC3)sc2c1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5090932 |  |
IC50 | = | 21.0 | nM | 446.97 | CN1CCc2nc(NC(=O)[C@H]3CC[C@@H](n4cnc5c(N)nc(Cl)nc54)CC3)sc2C1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5077194 |  |
IC50 | = | 22.0 | nM | 443.92 | Nc1nc(Cl)nc2c1ncn2[C@H]1CC[C@@H](C(=O)Nc2nc3ccc(O)cc3s2)CC1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5075042 |  |
IC50 | = | 23.0 | nM | 457.95 | COc1ccc2nc(NC(=O)[C@H]3CC[C@@H](n4cnc5c(N)nc(Cl)nc54)CC3)sc2c1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5089356 |  |
IC50 | = | 27.0 | nM | 432.94 | Nc1nc(Cl)nc2c1ncn2[C@H]1CC[C@@H](C(=O)Nc2nc3c(s2)CNCC3)CC1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5085262 |  |
IC50 | = | 28.0 | nM | 445.91 | Nc1nc(Cl)nc2c1ncn2[C@H]1CC[C@@H](C(=O)Nc2nc3ccc(F)cc3s2)CC1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5084844 |  |
IC50 | = | 28.0 | nM | 427.92 | Nc1nc(Cl)nc2c1ncn2[C@H]1CC[C@@H](C(=O)Nc2nc3ccccc3s2)CC1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5090132 |  |
IC50 | = | 29.0 | nM | 457.95 | COc1cccc2sc(NC(=O)[C@H]3CC[C@@H](n4cnc5c(N)nc(Cl)nc54)CC3)nc12 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5081222 |  |
IC50 | = | 31.0 | nM | 470.95 | NC(=O)c1ccc2nc(NC(=O)[C@H]3CC[C@@H](n4cnc5c(N)nc(Cl)nc54)CC3)sc2c1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5075110 |  |
IC50 | = | 31.0 | nM | 430.51 | CN1CCc2nc(NC(=O)[C@H]3CC[C@@H](n4cnc5c(N)nc(F)nc54)CC3)sc2C1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5093152 |  |
IC50 | = | 31.0 | nM | 472.59 | CC1(C)Cc2nc(NC(=O)[C@H]3CC[C@@H](n4cnc5c(N)nc(F)nc54)CC3)sc2C(C)(C)N1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5088776 |  |
IC50 | = | 33.0 | nM | 443.92 | Nc1nc(Cl)nc2c1ncn2[C@H]1CC[C@@H](C(=O)Nc2nc3c(O)cccc3s2)CC1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5091201 |  |
IC50 | = | 34.0 | nM | 375.43 | Cc1csc(NC(=O)[C@H]2CC[C@@H](n3cnc4c(N)nc(F)nc43)CC2)n1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5086885 |  |
IC50 | = | 40.0 | nM | 391.89 | Cc1cnc(NC(=O)[C@H]2CC[C@@H](n3cnc4c(N)nc(Cl)nc43)CC2)s1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5078057 |  |
IC50 | = | 43.0 | nM | 475.02 | CC(C)N1CCc2nc(NC(=O)[C@H]3CC[C@@H](n4cnc5c(N)nc(Cl)nc54)CC3)sc2C1 | Homo sapiens | CHEMBL5029655 | single protein format |
| CHEMBL5088850 |  |
IC50 | = | 49.0 | nM | 481.99 | Nc1nc(Cl)nc2c1ncn2[C@H]1CC[C@@H](C(=O)Nc2nc3c(s2)CS(=O)(=O)CC3)CC1 | Homo sapiens | CHEMBL5029655 | single protein format |