P35610 | SOAT1_HUMAN | Sterol O-acyltransferase 1 (SOAT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03062 | MBOAT - MBOAT, membrane-bound O-acyltransferase family | 171~520 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4281138 |  |
IC50 | = | 3.0 | nM | 519.79 | CSc1cc(C)nc(SC)c1NC(=O)CN1CCN(CCSc2nc3ccccc3s2)CC1 | Homo sapiens | CHEMBL4265765 | cell-based format |
| CHEMBL3894947 |  |
IC50 | = | 4.2 | nM | 441.62 | CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C(Cc1ccccc1)Cc1ccccc1 | Homo sapiens | CHEMBL3887315 | single protein format |
| CHEMBL4247249 |  |
IC50 | = | 7.0 | nM | 466.69 | CC(C)c1cccc(C(C)C)c1NC(=O)CCCCCCCCSc1nc2ccccc2o1 | Homo sapiens | CHEMBL4265765 | cell-based format |
| CHEMBL46423 |  |
IC50 | = | 9.0 | nM | 421.63 | CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(c2ccc(N(C)C)cc2)CCCC1 | Homo sapiens | CHEMBL5243701 | cell-based format |
| CHEMBL4282905 |  |
IC50 | = | 9.0 | nM | 503.72 | CSc1cc(C)nc(SC)c1NC(=O)CN1CCN(CCSc2nc3ccccc3o2)CC1 | Homo sapiens | CHEMBL4265765 | cell-based format |
| CHEMBL284596 |  |
IC50 | = | 10.0 | nM | 566.75 | COc1ccc(N2CCN(CCCCC3(C)COC(c4nc(-c5ccccc5)c(-c5ccccc5)[nH]4)OC3)CC2)cc1 | Homo sapiens | CHEMBL643993 | single protein format |
| CHEMBL3905226 |  |
IC50 | = | 10.3 | nM | 457.61 | CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C(Cc1ccccc1)Cc1ccc(O)cc1 | Homo sapiens | CHEMBL3887315 | single protein format |
| CHEMBL449307 |  |
IC50 | = | 20.0 | nM | 563.74 | CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 | Homo sapiens | CHEMBL1936449 | single protein format |
| CHEMBL2397474 |  |
IC50 | = | 32.0 | nM | 595.87 | CCCCCCCCCN(CC(C)(C)C)C(=O)N[C@H]1CCCC[C@@H]1OC(=O)CCNC(=O)[C@@H]1OC(C)(C)OCC1(C)C | Homo sapiens | CHEMBL2398960 | single protein format |
| CHEMBL459999 |  |
IC50 | = | 35.0 | nM | 499.7 | COc1cccc(C2(CNC(=O)Nc3c(C(C)C)cccc3C(C)C)CCN(c3ccccc3)CC2)c1 | Homo sapiens | CHEMBL1027336 | cell-based format |
| CHEMBL1908306 |  |
IC50 | = | 39.0 | nM | 469.74 | CCCCCCCCCCCCS[C@H](C(=O)Nc1cc(C)c(O)c(C)c1C)c1ccccc1 | Homo sapiens | CHEMBL3882635 | single protein format |
| CHEMBL297271 |  |
IC50 | = | 40.0 | nM | 419.52 | O=C(N[C@@H]1c2ccccc2C[C@@H]1c1ccc(O)cc1)C(c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL643830 | single protein format |
| CHEMBL505016 |  |
IC50 | = | 40.0 | nM | 563.74 | CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 | Homo sapiens | CHEMBL1936449 | single protein format |
| CHEMBL449977 |  |
IC50 | = | 40.0 | nM | 587.64 | COc1cccc(C2(CNC(=O)Nc3c(C(C)C)cc(N)cc3C(C)C)CCN(c3ccccc3)CC2)c1.Cl.Cl | Homo sapiens | CHEMBL1027336 | cell-based format |
| CHEMBL304267 |  |
IC50 | = | 43.0 | nM | 487.77 | C/C=C/C/C=C/C/C=C/C/C=C/C/C=C/C/C=C/CCCC(=O)Nc1c(C(C)C)cccc1C(C)C | Homo sapiens | CHEMBL641211 | cell-based format |
| CHEMBL510453 |  |
IC50 | = | 47.0 | nM | 529.73 | COc1cccc(C2(CNC(=O)Nc3c(C(C)C)cccc3C(C)C)CCN(c3ccccc3OC)CC2)c1 | Homo sapiens | CHEMBL1027336 | cell-based format |
| CHEMBL34219 |  |
IC50 | = | 50.0 | nM | 543.74 | CC1(CCCCN2CCN(c3nccs3)CC2)COC(c2nc(-c3ccccc3)c(-c3ccccc3)[nH]2)OC1 | Homo sapiens | CHEMBL643993 | single protein format |
| CHEMBL284378 |  |
IC50 | = | 50.0 | nM | 482.63 | CN(CCCCC1(C)COC(c2nc(-c3ccccc3)c(-c3ccccc3)[nH]2)OC1)c1ccccn1 | Homo sapiens | CHEMBL643993 | single protein format |
| CHEMBL25532 |  |
IC50 | = | 58.0 | nM | 583.63 | CC(=O)OC[C@@]1(C)C2C[C@H](OC(C)=O)[C@@]3(C)Oc4cc(-c5cccnc5)oc(=O)c4[C@H](O)C3[C@@]2(C)CC[C@@H]1OC(C)=O | Homo sapiens | CHEMBL639637 | single protein format |
| CHEMBL285429 |  |
IC50 | = | 60.0 | nM | 484.64 | Cc1cc(C)n(CCCCCC2(C)COC(c3nc(-c4ccccc4)c(-c4ccccc4)[nH]3)OC2)n1 | Homo sapiens | CHEMBL643995 | single protein format |