P35558 | PCKGC_HUMAN | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] (PCK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00821 | PEPCK_GTP - Phosphoenolpyruvate carboxykinase C-terminal P-loop domain | 260~618 | |
| PF17297 | PEPCK_N - Phosphoenolpyruvate carboxykinase N-terminal domain | 29~256 |
3D structures mapped by conservation among orthologs
[ Domain: "PEP carboxykinase catalytic C-terminal domain" // PEPCK_C ]
[ Domain: "PEP carboxykinase N-terminal domain" // PEPCK_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL243342 |  |
IC50 | = | 230.0 | nM | 595.68 | Cc1nc(N)sc1S(=O)(=O)Nc1ccc(Cc2nc3c([nH]2)c(=O)n(Cc2ccccc2F)c(=O)n3CC2CC2)cc1 | Homo sapiens | CHEMBL889299 | single protein format |
| CHEMBL394621 |  |
IC50 | = | 240.0 | nM | 577.64 | Cc1nn(C)cc1S(=O)(=O)Nc1ccc(Cc2nc3c([nH]2)c(=O)n(Cc2ccccc2F)c(=O)n3CC2CC2)cc1 | Homo sapiens | CHEMBL889299 | single protein format |
| CHEMBL243343 |  |
IC50 | = | 340.0 | nM | 577.64 | Cc1nc(S(=O)(=O)Nc2ccc(Cc3nc4c([nH]3)c(=O)n(Cc3ccccc3F)c(=O)n4CC3CC3)cc2)cn1C | Homo sapiens | CHEMBL889299 | single protein format |
| CHEMBL243134 |  |
IC50 | = | 390.0 | nM | 563.62 | Cn1cc(S(=O)(=O)Nc2ccc(Cc3nc4c([nH]3)c(=O)n(Cc3ccccc3F)c(=O)n4CC3CC3)cc2)cn1 | Homo sapiens | CHEMBL889299 | single protein format |
| CHEMBL245018 |  |
IC50 | = | 630.0 | nM | 565.63 | CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(NS(=O)(=O)c4cn(C)cn4)cc3)nc21 | Homo sapiens | CHEMBL889299 | single protein format |
| CHEMBL244165 |  |
IC50 | = | 690.0 | nM | 461.5 | CC(=O)Nc1ccc(Cc2nc3c([nH]2)c(=O)n(Cc2ccccc2F)c(=O)n3CC2CC2)cc1 | Homo sapiens | CHEMBL889299 | single protein format |
| CHEMBL394368 |  |
IC50 | = | 790.0 | nM | 578.63 | Cc1noc(C)c1S(=O)(=O)Nc1ccc(Cc2nc3c([nH]2)c(=O)n(Cc2ccccc2F)c(=O)n3CC2CC2)cc1 | Homo sapiens | CHEMBL889299 | single protein format |
| CHEMBL244802 |  |
IC50 | = | 960.0 | nM | 526.59 | CN(C)S(=O)(=O)Nc1ccc(Cc2nc3c([nH]2)c(=O)n(Cc2ccccc2F)c(=O)n3CC2CC2)cc1 | Homo sapiens | CHEMBL889299 | single protein format |