P35498 | SCN1A_HUMAN | Sodium channel protein type 1 subunit alpha (SCN1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 127~432 | |
| PF00520 | Ion_trans - Ion transport protein | 768~998 | |
| PF00520 | Ion_trans - Ion transport protein | 1217~1492 | |
| PF00520 | Ion_trans - Ion transport protein | 1541~1796 | |
| PF06512 | Na_trans_assoc - Sodium ion transport-associated | 1006~1213 | |
| PF11933 | Na_trans_cytopl - Cytoplasmic domain of voltage-gated Na+ ion channel | 555~718 | |
| PF24609 | IQ_SCN5A_C - SCN5A-like, C-terminal IQ motif | 1908~1941 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL501134 |  |
IC50 | = | 2.3 | nM | 299.29 | N=C1N[C@H]2[C@H](COC(N)=O)NC(=N)N3CCC(O)(O)[C@]23N1 | Homo sapiens | CHEMBL4321991 | cell-based format |
| CHEMBL507974 |  |
IC50 | = | 4.1 | nM | 319.27 | NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO | Homo sapiens | CHEMBL4321991 | cell-based format |
| CHEMBL3662190 |  |
IC50 | = | 6.0 | nM | 435.56 | CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC2(CC1)CC2 | Homo sapiens | CHEMBL4321991 | cell-based format |
| CHEMBL3657855 |  |
IC50 | = | 11.0 | nM | 462.59 | O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F | Homo sapiens | CHEMBL4321991 | cell-based format |
| CHEMBL4293085 |  |
IC50 | = | 12.0 | nM | 510.88 | O=C(NCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccc(S(=O)(=O)Nc2ncns2)c(F)c1 | Homo sapiens | CHEMBL4257700 | single protein format |
| CHEMBL4276884 |  |
IC50 | = | 20.0 | nM | 509.89 | O=C(NCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccc(S(=O)(=O)Nc2nccs2)c(F)c1 | Homo sapiens | CHEMBL4257700 | single protein format |
| CHEMBL3617053 |  |
IC50 | = | 32.0 | nM | 449.56 | O=C(Nc1ccc(S(=O)(=O)Nc2nccs2)cc1)C(c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4257700 | single protein format |
| CHEMBL4290579 |  |
IC50 | = | 45.0 | nM | 442.59 | O=S(=O)(Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(C3CC3)cn12)C1CC1 | Homo sapiens | CHEMBL4256589 | cell-based format |
| CHEMBL3662077 |  |
IC50 | = | 48.0 | nM | 445.5 | CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC(F)(F)CC1 | Homo sapiens | CHEMBL5264216 | cell-based format |
| CHEMBL4279238 |  |
IC50 | = | 53.0 | nM | 416.55 | CS(=O)(=O)Nc1nnc2cc(OCC34CC5CC(CC(C5)C3)C4)c(C3CC3)cn12 | Homo sapiens | CHEMBL4256589 | cell-based format |
| CHEMBL4471012 |  |
IC50 | = | 100.0 | nM | 539.46 | Cc1nn([C@@H]2CCN([C@H](C)c3cc(Cl)cc(Cl)c3)C2)c2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc12 | Homo sapiens | CHEMBL5225021 | single protein format |
| CHEMBL4285790 |  |
IC50 | = | 112.0 | nM | 427.31 | CS(=O)(=O)Nc1nnc2cc(COc3cc(Cl)cc(Cl)c3)c(C3CC3)cn12 | Homo sapiens | CHEMBL4256589 | cell-based format |
| CHEMBL4444707 |  |
IC50 | = | 192.0 | nM | 563.01 | CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3cc(C(F)(F)F)ccc3Cl)CC2)cc1F | Homo sapiens | CHEMBL5225021 | single protein format |
| CHEMBL5094715 |  |
IC50 | = | 202.0 | nM | 543.49 | C[C@@H](c1cc(Cl)cc(Cl)c1)N1CCC(COc2cc(F)c(C(=O)NS(C)(=O)=O)cc2C2CC2)CC1 | Homo sapiens | CHEMBL5055698 | cell-based format |
| CHEMBL3809595 |  |
IC50 | = | 400.0 | nM | 347.22 | FC(F)(F)Oc1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 | Homo sapiens | CHEMBL3813476 | assay format |
| CHEMBL4276813 |  |
IC50 | = | 455.0 | nM | 465.86 | O=S(=O)(Nc1ncns1)c1ccc(OCc2ccc(OC(F)(F)F)c(Cl)c2)cc1 | Homo sapiens | CHEMBL4257700 | single protein format |
| CHEMBL4854735 |  |
IC50 | = | 620.0 | nM | 581.49 | O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)c(F)c1 | Homo sapiens | CHEMBL4813114 | single protein format |
| CHEMBL3632641 |  |
IC50 | = | 670.0 | nM | 470.57 | O=C(c1ccccc1)c1ccc(OCC(O)CN2CCC(N3Cc4ccccc4C3=O)CC2)cc1 | Homo sapiens | CHEMBL3636865 | single protein format |
| CHEMBL3632696 |  |
IC50 | = | 800.0 | nM | 422.45 | O=C(NC1CCN(CC(O)COc2ccc(C(F)(F)F)cc2)CC1)c1ccccc1 | Homo sapiens | CHEMBL3636865 | single protein format |
| CHEMBL2325014 |  |
IC50 | = | 850.0 | nM | 500.36 | Nc1[nH]ncc1-c1cc(Cl)ccc1Oc1cc(F)c(S(=O)(=O)Nc2cscn2)cc1Cl | Homo sapiens | CHEMBL4321991 | cell-based format |