P35414 | APJ_HUMAN | Apelin receptor (APLNR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 45~309 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tmA_Apelin_R ]
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_1_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5170657 |  |
Ki | = | 0.07 | nM | 551.02 | CCc1cccc(CC)c1-n1c(-c2ccn(C)n2)nc(=O)c(C(=O)N2CC[C@@H](c3ncc(Cl)cc3F)C2)c1O | Homo sapiens | CHEMBL5098805 | cell-based format |
| CHEMBL4873876 |  |
Ki | = | 0.074 | nM | 498.92 | CCOCc1nc(O)c(-c2nnc(Cc3ccc(Cl)cn3)o2)c(O)c1-c1c(OC)cccc1OC | Homo sapiens | CHEMBL4821007 | cell membrane format |
| CHEMBL4647996 |  |
Ki | = | 36.0 | nM | 556.75 | CCC(O)CNC(=O)C[C@H](CCC1CCCCC1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 | Homo sapiens | CHEMBL4627571 | cell-based format |
| CHEMBL4640815 |  |
Ki | = | 38.0 | nM | 556.75 | CC[C@@H](O)CNC(=O)C[C@H](CCC1CCCCC1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 | Homo sapiens | CHEMBL4627571 | cell-based format |
| CHEMBL4632564 |  |
Ki | = | 54.0 | nM | 538.73 | COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CCC2CCCCC2)CC(=O)NC2CCC2)nn1CC(C)C | Homo sapiens | CHEMBL4627571 | cell-based format |
| CHEMBL4647910 |  |
Ki | = | 59.0 | nM | 550.74 | COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CCC2CCCCC2)CC(=O)NC2CCC2)nn1C1CCCC1 | Homo sapiens | CHEMBL4627571 | cell-based format |
| CHEMBL4644803 |  |
Ki | = | 60.0 | nM | 524.71 | CCCn1nc(C(=O)N[C@@H](CCC2CCCCC2)CC(=O)NC2CCC2)cc1-c1c(OC)cccc1OC | Homo sapiens | CHEMBL4627571 | cell-based format |
| CHEMBL4875417 |  |
Ki | = | 90.0 | nM | 588.19 | COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CCN2CCCCC2)CC(=O)NC2CCC2)nn1C1CCCC1.Cl | Homo sapiens | CHEMBL4823545 | single protein format |
| CHEMBL4640653 |  |
Ki | = | 134.0 | nM | 550.66 | COC(=O)CN(C)C(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 | Homo sapiens | CHEMBL4627571 | cell-based format |
| CHEMBL4647391 |  |
Ki | = | 147.0 | nM | 564.77 | COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CCC2CCCCC2)CC(=O)NC2CCC2)nn1C1CCCCC1 | Homo sapiens | CHEMBL4627571 | cell-based format |
| CHEMBL4647853 |  |
Ki | = | 172.0 | nM | 554.73 | CCC(=O)CNC(=O)C[C@H](CCC1CCCCC1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 | Homo sapiens | CHEMBL4627571 | cell-based format |
| CHEMBL4647332 |  |
Ki | = | 187.0 | nM | 536.63 | COC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 | Homo sapiens | CHEMBL4627571 | cell-based format |
| CHEMBL4640390 |  |
Ki | = | 449.0 | nM | 532.69 | COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](CCc2ccccc2)CC(=O)NC2CCC2)nn1CC(C)C | Homo sapiens | CHEMBL4627571 | cell-based format |
| CHEMBL4641474 |  |
Ki | = | 571.0 | nM | 534.66 | CCC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 | Homo sapiens | CHEMBL4627571 | cell-based format |
| CHEMBL3818101 |  |
Ki | = | 600.0 | nM | 469.51 | COc1cccc(OC)c1-c1cc(C(=O)N[C@H](CC(=O)O)CC(C)C)nn1-c1ccc(F)cc1 | Homo sapiens | CHEMBL3820078 | cell-based format |