P35368 | ADA1B_HUMAN | Alpha-1B adrenergic receptor (ADRA1B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 62~348 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL430717 |  |
IC50 | = | 1.2 | nM | 495.58 | COc1cc2nc(N3CCN(C(=O)COc4c(OC)cccc4C(C)C)CC3)nc(N)c2cc1OC | Homo sapiens | CHEMBL649213 | single protein format |
| CHEMBL3582270 |  |
IC50 | = | 1.2 | nM | 599.65 | CCN(CC)c1ccc2cc(-n3cc(C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 | Homo sapiens | CHEMBL3583291 | cell-based format |
| CHEMBL19826 |  |
IC50 | = | 3.2 | nM | 482.54 | COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC | Homo sapiens | CHEMBL648106 | tissue-based format |
| CHEMBL3582269 |  |
IC50 | < | 5.0 | nM | 544.53 | COc1cc2nc(N3CCN(C(=O)c4cn(-c5cc6ccc(O)cc6oc5=O)nn4)CC3)nc(N)c2cc1OC | Homo sapiens | CHEMBL3583291 | cell-based format |
| CHEMBL3582268 |  |
IC50 | < | 5.0 | nM | 477.48 | COc1cc2nc(N3CCN(C(=O)c4cc5ccc(O)cc5oc4=O)CC3)nc(N)c2cc1OC | Homo sapiens | CHEMBL3583291 | cell-based format |
| CHEMBL19476 |  |
IC50 | = | 8.8 | nM | 522.61 | COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC | Homo sapiens | CHEMBL648107 | tissue-based format |
| CHEMBL597 |  |
IC50 | = | 10.8 | nM | 281.36 | Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 | Homo sapiens | CHEMBL3583291 | cell-based format |
| CHEMBL3739533 |  |
IC50 | = | 12.57 | nM | 426.52 | O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccn3)CC2)cc1 | Homo sapiens | CHEMBL3744074 | single protein format |
| CHEMBL3742253 |  |
IC50 | = | 19.69 | nM | 493.53 | O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 | Homo sapiens | CHEMBL3744074 | single protein format |
| CHEMBL3740019 |  |
IC50 | = | 28.91 | nM | 439.56 | Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 | Homo sapiens | CHEMBL3744074 | single protein format |
| CHEMBL19376 |  |
IC50 | = | 31.0 | nM | 388.47 | COc1cc2nc(N3CCN[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC | Homo sapiens | CHEMBL648107 | tissue-based format |
| CHEMBL3742103 |  |
IC50 | = | 31.62 | nM | 474.0 | Cc1ccc(Cl)cc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 | Homo sapiens | CHEMBL3744074 | single protein format |
| CHEMBL3740874 |  |
IC50 | = | 34.76 | nM | 468.53 | N#Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)c(F)c1 | Homo sapiens | CHEMBL3744074 | single protein format |
| CHEMBL1933288 |  |
IC50 | = | 52.0 | nM | 458.57 | C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 | Homo sapiens | CHEMBL5213135 | single protein format |
| CHEMBL3582272 |  |
IC50 | = | 52.4 | nM | 585.67 | CCN(CC)c1ccc2cc(-n3cc(CN4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 | Homo sapiens | CHEMBL3583291 | cell-based format |
| CHEMBL3741318 |  |
IC50 | = | 100.9 | nM | 455.56 | COc1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 | Homo sapiens | CHEMBL3744074 | single protein format |
| CHEMBL3740558 |  |
IC50 | = | 121.9 | nM | 467.57 | CC(=O)c1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 | Homo sapiens | CHEMBL3744074 | single protein format |
| CHEMBL3739762 |  |
IC50 | = | 180.0 | nM | 450.54 | [C-]#[N+]c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 | Homo sapiens | CHEMBL3744074 | single protein format |
| CHEMBL3742276 |  |
IC50 | = | 199.0 | nM | 503.62 | CS(=O)(=O)c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 | Homo sapiens | CHEMBL3744074 | single protein format |
| CHEMBL24619 |  |
IC50 | = | 206.0 | nM | 546.62 | COc1ccc(CC2c3cc(OC)c(OC)cc3CCN2c2nc(N)c3cc(OC)c(OC)cc3n2)cc1OC | Homo sapiens | CHEMBL649213 | single protein format |