P35348 | ADA1A_HUMAN | Alpha-1A adrenergic receptor (ADRA1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 43~326 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3582270 |  |
IC50 | = | 0.6 | nM | 599.65 | CCN(CC)c1ccc2cc(-n3cc(C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 | Homo sapiens | CHEMBL3583290 | cell-based format |
| CHEMBL597 |  |
IC50 | = | 1.1 | nM | 281.36 | Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 | Homo sapiens | CHEMBL3583290 | cell-based format |
| CHEMBL3740019 |  |
IC50 | = | 2.03 | nM | 439.56 | Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 | Homo sapiens | CHEMBL3744073 | single protein format |
| CHEMBL3582269 |  |
IC50 | = | 2.5 | nM | 544.53 | COc1cc2nc(N3CCN(C(=O)c4cn(-c5cc6ccc(O)cc6oc5=O)nn4)CC3)nc(N)c2cc1OC | Homo sapiens | CHEMBL3583290 | cell-based format |
| CHEMBL3582268 |  |
IC50 | = | 3.9 | nM | 477.48 | COc1cc2nc(N3CCN(C(=O)c4cc5ccc(O)cc5oc4=O)CC3)nc(N)c2cc1OC | Homo sapiens | CHEMBL3583290 | cell-based format |
| CHEMBL85 |  |
IC50 | = | 10.0 | nM | 410.49 | Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2 | Homo sapiens | CHEMBL3806811 | single protein format |
| CHEMBL3740558 |  |
IC50 | = | 14.25 | nM | 467.57 | CC(=O)c1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 | Homo sapiens | CHEMBL3744073 | single protein format |
| CHEMBL3742198 |  |
IC50 | = | 15.16 | nM | 459.98 | O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccc3Cl)CC2)cc1 | Homo sapiens | CHEMBL3744073 | single protein format |
| CHEMBL3741318 |  |
IC50 | = | 30.12 | nM | 455.56 | COc1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 | Homo sapiens | CHEMBL3744073 | single protein format |
| CHEMBL3740351 |  |
IC50 | = | 32.43 | nM | 469.59 | CCOc1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 | Homo sapiens | CHEMBL3744073 | single protein format |
| CHEMBL3742103 |  |
IC50 | = | 34.47 | nM | 474.0 | Cc1ccc(Cl)cc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 | Homo sapiens | CHEMBL3744073 | single protein format |
| CHEMBL3805559 |  |
IC50 | = | 35.0 | nM | 425.5 | CNC(=O)c1cccc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1 | Homo sapiens | CHEMBL3806811 | single protein format |
| CHEMBL3739762 |  |
IC50 | = | 36.14 | nM | 450.54 | [C-]#[N+]c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 | Homo sapiens | CHEMBL3744073 | single protein format |
| CHEMBL5206987 |  |
IC50 | = | 43.0 | nM | 363.53 | [11CH3]Oc1cccc2c1CCCC2CCCN1CCN(c2ccccc2)CC1 | Homo sapiens | CHEMBL5109893 | single protein format |
| CHEMBL3742276 |  |
IC50 | = | 46.44 | nM | 503.62 | CS(=O)(=O)c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 | Homo sapiens | CHEMBL3744073 | single protein format |
| CHEMBL3739533 |  |
IC50 | = | 49.61 | nM | 426.52 | O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccn3)CC2)cc1 | Homo sapiens | CHEMBL3744073 | single protein format |
| CHEMBL3582272 |  |
IC50 | = | 52.4 | nM | 585.67 | CCN(CC)c1ccc2cc(-n3cc(CN4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 | Homo sapiens | CHEMBL3583290 | cell-based format |
| CHEMBL3742253 |  |
IC50 | = | 66.23 | nM | 493.53 | O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 | Homo sapiens | CHEMBL3744073 | single protein format |
| CHEMBL3741260 |  |
IC50 | = | 89.24 | nM | 450.54 | N#Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 | Homo sapiens | CHEMBL3744073 | single protein format |
| CHEMBL3741161 |  |
IC50 | = | 89.94 | nM | 461.51 | O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(F)cc3F)CC2)cc1 | Homo sapiens | CHEMBL3744073 | single protein format |