P35270 | SPRE_HUMAN | Sepiapterin reductase (SPR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00106 | adh_short - short chain dehydrogenase | 9~211 |
3D structures mapped by conservation among orthologs
[ Domain: "NAD(P)-binding Rossmann-fold domains" // adh_short_C2_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4563610 |  |
IC50 | = | 1.0 | nM | 458.51 | Cc1c(C(=O)N2CCc3nc(-c4cccnc4)sc3C2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4562941 |  |
IC50 | = | 1.0 | nM | 473.54 | Cc1c(C(=O)N2CCN(S(=O)(=O)c3cccs3)CC2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4554409 |  |
IC50 | = | 1.0 | nM | 478.44 | Cc1c(C(=O)Nc2c(C(C)(O)C(F)(F)F)cnn2C(C)C)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4593801 |  |
IC50 | = | 1.0 | nM | 366.43 | Cc1c(C(=O)N2CCC3(CCCC3)C2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4572718 |  |
IC50 | = | 1.0 | nM | 393.38 | Cc1c(C(=O)N2CC(c3ccc(F)nc3)C2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4527183 |  |
IC50 | = | 1.0 | nM | 501.96 | Cc1c(C(=O)N2CCN(S(=O)(=O)c3cccc(Cl)c3)CC2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4525880 |  |
IC50 | = | 1.0 | nM | 374.35 | Cc1c(C(=O)N2CC3CC(F)(F)C3C2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4519582 |  |
IC50 | = | 1.0 | nM | 410.36 | Cc1c(C(=O)N2CCC(O)(C(F)(F)F)CC2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4563028 |  |
IC50 | = | 1.0 | nM | 403.45 | Cc1c(C(=O)N2CCN(c3ccccc3)CC2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4551686 |  |
IC50 | = | 1.0 | nM | 485.5 | Cc1c(C(=O)N2CCN(S(=O)(=O)c3cccc(F)c3)CC2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4520342 |  |
IC50 | = | 1.0 | nM | 374.35 | Cc1c(C(=O)N2CC3CC(C2)C3(F)F)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4565427 |  |
IC50 | = | 1.0 | nM | 444.5 | Cc1c(C(=O)N2C3CCC2CC(O)(c2ccccc2)C3)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4520726 |  |
IC50 | = | 1.0 | nM | 352.4 | Cc1c(C(=O)N2CC3(CCCC3)C2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4556382 |  |
IC50 | = | 1.0 | nM | 388.38 | Cc1c(C(=O)N2CC3CC(F)(F)CC3C2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4574375 |  |
IC50 | = | 1.0 | nM | 422.33 | Cc1c(C(=O)N2CCC(C(F)(F)F)CC2)cnn1-c1cc(C(F)(F)F)cc(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4581306 |  |
IC50 | = | 1.0 | nM | 354.37 | O=C(c1cn(-c2nn3cccc3c(=O)[nH]2)nn1)N1CCN(C2CC2)CC1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4554750 |  |
IC50 | = | 1.0 | nM | 408.46 | Cc1c(C(=O)N2CCC3(CCCCC3=O)CC2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4535900 |  |
IC50 | = | 1.0 | nM | 416.45 | Cc1c(C(=O)N2CCC(n3cccc3C#N)CC2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4544256 |  |
IC50 | = | 1.0 | nM | 453.5 | Cc1c(C(=O)N2CC3(CCCN3C(=O)OC(C)(C)C)C2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |
| CHEMBL4563399 |  |
IC50 | = | 1.0 | nM | 424.38 | Cc1c(C(=O)N2CCC(OCC(F)(F)F)CC2)cnn1-c1nn2cccc2c(=O)[nH]1 | Homo sapiens | CHEMBL4482726 | single protein format |