P35228 | NOS2_HUMAN | Nitric oxide synthase, inducible (NOS2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00175 | NAD_binding_1 - Oxidoreductase NAD-binding domain | 979~1092 | |
| PF00258 | Flavodoxin_1 - Flavodoxin | 541~672 | |
| PF00667 | FAD_binding_1 - FAD binding domain | 726~947 | |
| PF02898 | NO_synthase - Nitric oxide synthase, oxygenase domain | 137~497 |
3D structures mapped by conservation among orthologs
[ Domain: "Nitric oxide (NO) synthase oxygenase domain" // NO_synthase ]
[ Domain: "Flavoproteins" // Flavodoxin_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL220632 |  |
IC50 | = | 0.12 | nM | 420.47 | Cc1cc(N2CCC[C@@H]2CC(=O)NCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL220880 |  |
IC50 | = | 0.13 | nM | 434.5 | CCc1cc(N2CCC[C@@H]2CC(=O)NCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL1093059 |  |
IC50 | = | 0.2 | nM | 491.67 | CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](C(=O)C=C4[C@@]5(C)C=C(C#N)C(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 | Homo sapiens | CHEMBL827657 | single protein format |
| CHEMBL385324 |  |
IC50 | = | 0.24 | nM | 479.5 | COC(=O)N1CCN(c2ccnc(-n3ccnc3)n2)[C@@H](CC(=O)NCc2ccc3c(c2)OCO3)C1 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL376733 |  |
IC50 | = | 0.28 | nM | 406.45 | O=C(C[C@H]1CCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL385325 |  |
IC50 | = | 0.28 | nM | 516.54 | O=C(CC1CN(c2cccc(F)n2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL376632 |  |
IC50 | = | 0.29 | nM | 420.47 | Cc1cc(N2CCC[C@@H]2C(=O)NCCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL427062 |  |
IC50 | = | 0.48 | nM | 406.45 | O=C(NCCc1ccc2c(c1)OCO2)[C@H]1CCCN1c1ccnc(-n2ccnc2)n1 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL373623 |  |
IC50 | = | 0.48 | nM | 435.49 | CN1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL223788 |  |
IC50 | = | 0.49 | nM | 454.92 | O=C(CC1CCCCN1c1cc(Cl)nc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL442041 |  |
IC50 | = | 0.5 | nM | 420.47 | O=C(CC1CCCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL376713 |  |
IC50 | = | 0.5 | nM | 569.62 | O=C(CC1CN(C(=O)COCc2ccccc2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL385334 |  |
IC50 | = | 0.5 | nM | 525.57 | O=C(CC1CN(C(=O)c2ccccc2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL220932 |  |
IC50 | = | 0.5 | nM | 422.45 | O=C(CC1COCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL221208 |  |
IC50 | = | 0.52 | nM | 434.5 | CCc1cc(N2CCC[C@@H]2C(=O)NCCc2ccc3c(c2)OCO3)nc(-n2ccnc2)n1 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL411343 |  |
IC50 | = | 0.55 | nM | 421.46 | O=C(CC1CNCCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL424928 |  |
IC50 | = | 0.58 | nM | 501.55 | O=C(CC1CN(Cc2ccco2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL290548 |  |
IC50 | = | 0.6 | nM | 479.5 | COC(=O)N1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 | Homo sapiens | CHEMBL701144 | single protein format |
| CHEMBL223782 |  |
IC50 | = | 0.67 | nM | 515.53 | O=C(CC1CN(C(=O)c2ccco2)CCN1c1ccnc(-n2ccnc2)n1)NCc1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL920402 | cell-based format |
| CHEMBL373881 |  |
IC50 | = | 0.7 | nM | 499.55 | CS(=O)(=O)N1CCN(c2ccnc(-n3ccnc3)n2)C(CC(=O)NCc2ccc3c(c2)OCO3)C1 | Homo sapiens | CHEMBL920402 | cell-based format |