P34998 | CRFR1_HUMAN | Corticotropin-releasing factor receptor 1 (CRHR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00002 | 7tm_2 - 7 transmembrane receptor (Secretin family) | 119~359 | |
| PF02793 | HRM - Hormone receptor domain | 42~104 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_2 ]
[ Domain: "Hormone receptor domain (HRM, Pfam 02793)" // HRM_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL484158 |  |
IC50 | = | 1.2 | nM | 391.88 | CCC(CC)Nc1nc(C)nc2c(-c3cc(F)c(OC)cc3Cl)c(C)nn12 | Homo sapiens | CHEMBL985701 | cell-based format |
| CHEMBL1939601 |  |
IC50 | = | 2.0 | nM | 367.49 | CCC(CC)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12 | Homo sapiens | CHEMBL1942636 | cell-based format |
| CHEMBL1830524 |  |
IC50 | = | 2.4 | nM | 377.49 | CCc1cc(OC)ccc1Nc1nc2ccnn2c2c1ccn2C(CC)CC | Homo sapiens | CHEMBL1833625 | cell-based format |
| CHEMBL1939570 |  |
IC50 | = | 2.6 | nM | 353.47 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12 | Homo sapiens | CHEMBL1942636 | cell-based format |
| CHEMBL1819083 |  |
IC50 | = | 3.0 | nM | 434.92 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC(F)F)cc4Cl)c(C)nn13)CCC2 | Homo sapiens | CHEMBL1821007 | cell-based format |
| CHEMBL1830523 |  |
IC50 | = | 3.2 | nM | 383.88 | CCC(CC)n1ccc2c(Nc3ccc(OC)cc3Cl)nc3ccnn3c21 | Homo sapiens | CHEMBL1833625 | cell-based format |
| CHEMBL1939590 |  |
IC50 | = | 3.3 | nM | 393.53 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC3CC3)c(=O)c12 | Homo sapiens | CHEMBL1942636 | cell-based format |
| CHEMBL506214 |  |
IC50 | = | 3.4 | nM | 369.47 | CC[C@@H](C)Nc1nc(C)nc2c(-c3c(C)cc(OC)cc3OC)c(C)nn12 | Homo sapiens | CHEMBL985701 | cell-based format |
| CHEMBL1939593 |  |
IC50 | = | 3.8 | nM | 354.45 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)nc3C)n(C)c(=O)c12 | Homo sapiens | CHEMBL1942636 | cell-based format |
| CHEMBL1939571 |  |
IC50 | = | 3.8 | nM | 373.88 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12 | Homo sapiens | CHEMBL1942636 | cell-based format |
| CHEMBL1819077 |  |
IC50 | = | 4.0 | nM | 398.94 | CCC(CC)Nc1c2c(nc3c(-c4ccc(OC)cc4Cl)c(C)nn13)CCC2 | Homo sapiens | CHEMBL1821007 | cell-based format |
| CHEMBL4069551 |  |
IC50 | = | 4.1 | nM | 411.76 | CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12 | Homo sapiens | CHEMBL4002315 | cell-based format |
| CHEMBL1939603 |  |
IC50 | = | 4.2 | nM | 353.47 | CCC(C)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12 | Homo sapiens | CHEMBL1942636 | cell-based format |
| CHEMBL1828890 |  |
IC50 | = | 4.2 | nM | 401.94 | CCCN(CCC)c1c(CC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12 | Homo sapiens | CHEMBL1833625 | cell-based format |
| CHEMBL1939585 |  |
IC50 | = | 4.4 | nM | 403.91 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CCO)c(=O)c12 | Homo sapiens | CHEMBL1942636 | cell-based format |
| CHEMBL1828900 |  |
IC50 | = | 4.4 | nM | 413.95 | C=CCN(c1cc(N(CCC)CCC)n2nccc2n1)c1ccc(OC)cc1Cl | Homo sapiens | CHEMBL1833625 | cell-based format |
| CHEMBL1939594 |  |
IC50 | = | 4.5 | nM | 390.43 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC(F)F)nc3C)n(C)c(=O)c12 | Homo sapiens | CHEMBL1942636 | cell-based format |
| CHEMBL482950 |  |
IC50 | = | 4.5 | nM | 340.43 | CC[C@@H](C)Nc1nc(C)nc2c(-c3ccc(OC)nc3C)c(C)nn12 | Homo sapiens | CHEMBL994499 | cell-based format |
| CHEMBL1939583 |  |
IC50 | = | 4.6 | nM | 387.91 | CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CC)c(=O)c12 | Homo sapiens | CHEMBL1942636 | cell-based format |
| CHEMBL475306 |  |
IC50 | = | 4.7 | nM | 399.5 | COCCN(CCOC)c1nc(C)nc2c(-c3ccc(OC)cc3C)c(C)nn12 | Homo sapiens | CHEMBL985701 | cell-based format |