P34995 | PE2R1_HUMAN | Prostaglandin E2 receptor EP1 subtype (PTGER1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 67~351 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3127163 |  |
IC50 | = | 0.6 | nM | 389.36 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(C(F)(F)F)cc32)n1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL3092131 |  |
IC50 | = | 0.9 | nM | 359.41 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c2-c2ccccc2C3)n1 | Homo sapiens | CHEMBL3095969 | single protein format |
| CHEMBL3127157 |  |
IC50 | = | 1.0 | nM | 335.39 | Cc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL3127159 |  |
IC50 | = | 1.1 | nM | 351.39 | COc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL548 |  |
IC50 | = | 1.1 | nM | 352.47 | CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O | Homo sapiens | CHEMBL1120700 | single protein format |
| CHEMBL3127156 |  |
IC50 | = | 2.0 | nM | 339.35 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccc(F)cc32)n1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL3092133 |  |
IC50 | = | 2.0 | nM | 373.44 | O=C(O)c1csc(-n2nc3c(c2-c2ccccc2)CCc2ccccc2-3)n1 | Homo sapiens | CHEMBL3095969 | single protein format |
| CHEMBL3127175 |  |
IC50 | = | 2.4 | nM | 321.36 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3ccccc32)n1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL3127167 |  |
IC50 | = | 4.0 | nM | 351.39 | COc1ccc(-c2nn(-c3nc(C(=O)O)cs3)c3ccccc23)cc1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL3127170 |  |
IC50 | = | 4.0 | nM | 325.39 | O=C(O)c1csc(-n2nc(C3=CCCCC3)c3ccccc32)n1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL3127164 |  |
IC50 | = | 4.5 | nM | 339.35 | O=C(O)c1csc(-n2nc(-c3ccc(F)cc3)c3ccccc32)n1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL362543 |  |
IC50 | = | 5.0 | nM | 420.92 | O=C(O)c1cccc(-c2sccc2-c2cc(Cl)ccc2OCc2ccccc2)c1 | Homo sapiens | CHEMBL870036 | cell-based format |
| CHEMBL257997 |  |
IC50 | = | 6.3 | nM | 356.81 | CC(C)Cc1cn(-c2nc(C(=O)[O-])cs2)c2cc(Cl)ccc12.[Na+] | Homo sapiens | CHEMBL931249 | cell-based format |
| CHEMBL3127166 |  |
IC50 | = | 12.0 | nM | 355.81 | O=C(O)c1csc(-n2nc(-c3ccc(Cl)cc3)c3ccccc32)n1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL467510 |  |
IC50 | = | 16.0 | nM | 403.84 | CC(C)COc1ccc(Cl)cc1-c1ccccc1-c1cccc(C(=O)[O-])n1.[Na+] | Homo sapiens | CHEMBL1010712 | single protein format |
| CHEMBL3127177 |  |
IC50 | = | 16.0 | nM | 325.39 | O=C(O)c1csc(-n2nc(-c3ccccc3)c3c2CCCC3)n1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL3127173 |  |
IC50 | = | 16.0 | nM | 328.4 | O=C(O)c1csc(-n2nc(N3CCCCC3)c3ccccc32)n1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL3127161 |  |
IC50 | = | 19.0 | nM | 336.38 | Nc1ccc2c(-c3ccccc3)nn(-c3nc(C(=O)O)cs3)c2c1 | Homo sapiens | CHEMBL3131142 | single protein format |
| CHEMBL3092153 |  |
IC50 | = | 20.0 | nM | 426.3 | O=C(O)c1csc(-n2nc(-c3ccccc3)c(Br)c2-c2ccccc2)n1 | Homo sapiens | CHEMBL3095969 | single protein format |
| CHEMBL3092130 |  |
IC50 | = | 20.0 | nM | 362.41 | Nc1c(-c2ccccc2)nn(-c2nc(C(=O)O)cs2)c1-c1ccccc1 | Homo sapiens | CHEMBL3095969 | single protein format |