P34972 | CNR2_HUMAN | Cannabinoid receptor 2 (CNR2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 50~299 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL401132 |  |
IC50 | = | 0.41 | nM | 430.92 | Cc1c(C(C)(C)C)s/c(=N\C(=O)c2cccc(C(F)(F)F)c2Cl)n1CC1CC1 | Homo sapiens | CHEMBL925386 | cell-based format |
| CHEMBL247830 |  |
IC50 | = | 0.5 | nM | 396.48 | Cc1c(C(C)(C)C)s/c(=N\C(=O)c2ccccc2C(F)(F)F)n1CC1CC1 | Homo sapiens | CHEMBL925386 | cell-based format |
| CHEMBL3099056 |  |
IC50 | = | 0.58 | nM | 416.88 | COc1nc(NCCc2ccc(F)cc2)nc(-c2ccc(Cl)c(C(C)(C)O)c2)n1 | Homo sapiens | CHEMBL3101346 | single protein format |
| CHEMBL262865 |  |
IC50 | = | 0.77 | nM | 354.49 | CC1(C)C(C(=O)c2cn(CCN3CCOCC3)c3ccccc23)C1(C)C | Homo sapiens | CHEMBL921013 | single protein format |
| CHEMBL3669094 |  |
IC50 | = | 1.0 | nM | 393.4 | COc1nc(NCCc2ccc(F)cc2)nc(-c2ccc(F)c3cccnc23)n1 | Homo sapiens | CHEMBL3706285 | assay format |
| CHEMBL3669116 |  |
IC50 | = | 1.0 | nM | 431.86 | COc1nc(NCCc2ccc(F)cc2)nc(-c2ccc(Cl)c(OCC(N)=O)c2)n1 | Homo sapiens | CHEMBL3706285 | assay format |
| CHEMBL3669058 |  |
IC50 | = | 1.0 | nM | 412.47 | COc1nc(NCCc2ccc(F)cc2)nc(-c2ccc(OC)c(C(C)(C)O)c2)n1 | Homo sapiens | CHEMBL3706285 | assay format |
| CHEMBL263913 |  |
IC50 | = | 1.1 | nM | 425.47 | Cn1c(C(C)(C)C)c/c(=N\C(=O)c2cccc(C(F)(F)F)c2F)n1CC1CCCC1 | Homo sapiens | CHEMBL920995 | cell-based format |
| CHEMBL5198892 |  |
IC50 | = | 1.17 | nM | 397.49 | O=C(NC12CC3CC(CC(C3)C1)C2)c1cc2cccnc2n(CCCCF)c1=O | Homo sapiens | CHEMBL5149210 | cell membrane format |
| CHEMBL398713 |  |
IC50 | = | 1.2 | nM | 426.5 | COc1ccc(C(F)(F)F)cc1C(=O)/N=c1\sc(C(C)(C)C)c(C)n1CC1CC1 | Homo sapiens | CHEMBL925386 | cell-based format |
| CHEMBL247996 |  |
IC50 | = | 1.2 | nM | 407.38 | Cc1c(C(C)(C)C)s/c(=N\C(=O)c2cccc(Br)c2)n1CC1CC1 | Homo sapiens | CHEMBL925386 | cell-based format |
| CHEMBL3669056 |  |
IC50 | = | 1.2 | nM | 464.9 | COc1nc(NCCc2ccc(OC(F)F)cc2)nc(-c2ccc(Cl)c(C(C)(C)O)c2)n1 | Homo sapiens | CHEMBL3706285 | assay format |
| CHEMBL559612 |  |
IC50 | = | 1.3 | nM | 376.58 | CCCCCCC(C)(C)c1ccc([C@@H]2C[C@H](O)CC[C@H]2CCCO)c(O)c1 | Homo sapiens | CHEMBL895094 | cell-based format |
| CHEMBL466651 |  |
IC50 | = | 1.37 | nM | 393.46 | CC1CCC(NC(=O)c2cc3cccnc3n(Cc3ccc(F)cc3)c2=O)CC1 | Homo sapiens | CHEMBL3383059 | single protein format |
| CHEMBL3099055 |  |
IC50 | = | 1.4 | nM | 435.89 | [2H]C([2H])([18F])Oc1nc(NCCc2ccc(F)cc2)nc(-c2ccc(Cl)c(C(C)(C)O)c2)n1 | Homo sapiens | CHEMBL4030391 | single protein format |
| CHEMBL3099054 |  |
IC50 | = | 1.4 | nM | 434.87 | CC(C)(O)c1cc(-c2nc(NCCc3ccc(F)cc3)nc(OCF)n2)ccc1Cl | Homo sapiens | CHEMBL3101345 | cell-based format |
| CHEMBL264154 |  |
IC50 | = | 1.7 | nM | 411.44 | Cn1c(C(C)(C)C)c/c(=N\C(=O)c2cccc(C(F)(F)F)c2F)n1CC1CCC1 | Homo sapiens | CHEMBL920995 | cell-based format |
| CHEMBL271824 |  |
IC50 | = | 1.7 | nM | 445.39 | Cc1c(C(=O)NC2CCCCC2)nn(-c2ccc(Cl)c(Cl)c2)c1-n1c(C)ccc1C | Homo sapiens | CHEMBL933207 | cell-based format |
| CHEMBL452912 |  |
IC50 | = | 2.0 | nM | 295.47 | CCCCCCCCC/C=C/C=C/C(=O)NCC(C)(C)O | Homo sapiens | CHEMBL3089351 | cell-based format |
| CHEMBL3780166 |  |
IC50 | = | 2.0 | nM | 408.54 | CCCCCn1c(=O)c(C(=O)NC23CC4CC(CC(C4)C2)C3)c(O)c2ccccc21 | Homo sapiens | CHEMBL3782259 | cell-based format |