P34969 | 5HT7R_HUMAN | 5-hydroxytryptamine receptor 7 (HTR7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 98~384 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4128926 |  |
IC50 | = | 0.39 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121505 | single protein format |
| CHEMBL39 |  |
IC50 | = | 0.61 | nM | 176.22 | NCCc1c[nH]c2ccc(O)cc12 | Homo sapiens | CHEMBL947387 | single protein format |
| CHEMBL282199 |  |
IC50 | = | 2.6 | nM | 352.5 | CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(O)c2)CC1 | Homo sapiens | CHEMBL4343035 | cell-based format |
| CHEMBL93240 |  |
IC50 | = | 3.1 | nM | 356.56 | CSc1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2 | Homo sapiens | CHEMBL921838 | single protein format |
| CHEMBL602878 |  |
IC50 | = | 6.3 | nM | 532.63 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1 | Homo sapiens | CHEMBL1067145 | cell-based format |
| CHEMBL495678 |  |
IC50 | = | 12.0 | nM | 477.55 | O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1 | Homo sapiens | CHEMBL958975 | cell-based format |
| CHEMBL4582321 |  |
IC50 | = | 12.0 | nM | 557.67 | CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | Homo sapiens | CHEMBL4343396 | single protein format |
| CHEMBL260907 |  |
IC50 | = | 12.0 | nM | 543.64 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1 | Homo sapiens | CHEMBL921838 | single protein format |
| CHEMBL602677 |  |
IC50 | = | 12.3 | nM | 494.66 | COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1 | Homo sapiens | CHEMBL1067145 | cell-based format |
| CHEMBL261742 |  |
IC50 | = | 16.0 | nM | 573.67 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1 | Homo sapiens | CHEMBL921838 | single protein format |
| CHEMBL406221 |  |
IC50 | = | 16.0 | nM | 573.67 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1 | Homo sapiens | CHEMBL921838 | single protein format |
| CHEMBL258785 |  |
IC50 | = | 19.0 | nM | 543.64 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1 | Homo sapiens | CHEMBL921838 | single protein format |
| CHEMBL497749 |  |
IC50 | = | 20.0 | nM | 439.58 | COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1 | Homo sapiens | CHEMBL958975 | cell-based format |
| CHEMBL428781 |  |
IC50 | = | 21.0 | nM | 511.63 | COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | Homo sapiens | CHEMBL921838 | single protein format |
| CHEMBL601885 |  |
IC50 | = | 24.0 | nM | 536.74 | COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1 | Homo sapiens | CHEMBL1067145 | cell-based format |
| CHEMBL261231 |  |
IC50 | = | 26.0 | nM | 525.65 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1 | Homo sapiens | CHEMBL921838 | single protein format |
| CHEMBL260756 |  |
IC50 | = | 29.0 | nM | 555.68 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1 | Homo sapiens | CHEMBL921838 | single protein format |
| CHEMBL408717 |  |
IC50 | = | 29.0 | nM | 555.68 | CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1 | Homo sapiens | CHEMBL921838 | single protein format |
| CHEMBL602889 |  |
IC50 | = | 35.3 | nM | 482.63 | O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1 | Homo sapiens | CHEMBL1067145 | cell-based format |
| CHEMBL427518 |  |
IC50 | = | 37.0 | nM | 419.55 | COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1 | Homo sapiens | CHEMBL958975 | cell-based format |