P34947 | GRK5_HUMAN | G protein-coupled receptor kinase 5 (GRK5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 187~448 | |
| PF00615 | RGS - Regulator of G protein signaling domain | 53~170 |
3D structures mapped by conservation among orthologs
[ Domain: "Regulator of G-protein signaling, RGS" // RGS ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4786599 |  |
IC50 | = | 3.8 | nM | 508.98 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)Cc4ccc(F)cc4)cc32)c(C)c1NC(=O)CCl | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL4785430 |  |
IC50 | = | 8.6 | nM | 521.42 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1NC(=O)CBr | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL4877302 |  |
IC50 | = | 12.0 | nM | 438.92 | CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3cccc(OC)c23)n[nH]1 | Homo sapiens | CHEMBL4810443 | single protein format |
| CHEMBL4800665 |  |
IC50 | = | 15.0 | nM | 527.67 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL4780266 |  |
IC50 | = | 15.0 | nM | 553.43 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)Cc4ccc(F)cc4)cc32)c(C)c1NC(=O)CBr | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL5415336 |  |
IC50 | = | 20.0 | nM | 475.01 | NCCCNCCCCNCCCNc1cc2nc(-c3ccccc3Cl)[nH]c(=O)c2cc1F | Homo sapiens | CHEMBL5353391 | single protein format |
| CHEMBL4782014 |  |
IC50 | = | 21.0 | nM | 466.54 | C#CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL4854871 |  |
IC50 | = | 26.0 | nM | 407.45 | CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(OC)c23)n[nH]1 | Homo sapiens | CHEMBL4810443 | single protein format |
| CHEMBL4794078 |  |
IC50 | = | 29.0 | nM | 505.02 | Cc1cccc(C[C@@H](C)NC(=O)c2ccc3c(c2)/C(=C/c2[nH]c(C)c(NC(=O)CCl)c2C)C(=O)N3)c1 | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL4781735 |  |
IC50 | = | 48.0 | nM | 468.56 | C=CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL4847703 |  |
IC50 | = | 51.0 | nM | 393.43 | CCc1cc(Nc2nc(NCc3ccc(F)cn3)nc3cccc(OC)c23)n[nH]1 | Homo sapiens | CHEMBL4810443 | single protein format |
| CHEMBL3093151 |  |
IC50 | = | 59.0 | nM | 429.53 | Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(N3CCCC3)cc2o1 | Homo sapiens | CHEMBL3096888 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 73.3 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328436 | single protein format |
| CHEMBL4787507 |  |
IC50 | = | 80.0 | nM | 506.99 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1NC(=O)C(O)CCl | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL4779427 |  |
IC50 | = | 87.0 | nM | 519.05 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@@H](Cc4ccccc4)C(C)C)cc32)c(C)c1NC(=O)CCl | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL4786185 |  |
IC50 | = | 91.0 | nM | 480.57 | C#CCCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL4786846 |  |
IC50 | = | 95.0 | nM | 519.0 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)NC4(Cc5ccccc5)COC4)cc32)c(C)c1NC(=O)CCl | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL4799210 |  |
IC50 | = | 110.0 | nM | 525.44 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)Cc4ccc(Cl)cc4)cc32)c(C)c1NC(=O)CCl | Homo sapiens | CHEMBL4775829 | assay format |
| CHEMBL3093260 |  |
IC50 | = | 120.0 | nM | 429.53 | Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2cc(N3CCCC3)ccc2o1 | Homo sapiens | CHEMBL3096888 | single protein format |
| CHEMBL4784634 |  |
IC50 | = | 130.0 | nM | 476.96 | Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)NCCc4ccccc4)cc32)c(C)c1NC(=O)CCl | Homo sapiens | CHEMBL4775829 | assay format |