P34903 | GBRA3_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02931 | Neur_chan_LBD - Neurotransmitter-gated ion-channel ligand binding domain | 68~275 | |
| PF02932 | Neur_chan_memb - Neurotransmitter-gated ion-channel transmembrane region | 282~475 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2008708 |  |
IC50 | = | 16.0 | nM | 258.28 | c1ccc2c(c1)[nH]c1cnc3c4cccnc4[nH]c3c12 | Homo sapiens | CHEMBL5235584 | single protein format |
| CHEMBL5281056 |  |
IC50 | = | 31.0 | nM | 258.28 | c1ccc2c(c1)[nH]c1cnc3c4ccncc4[nH]c3c12 | Homo sapiens | CHEMBL5235584 | single protein format |
| CHEMBL45198 |  |
Ki | = | 0.5 | nM | 386.48 | Cc1csc(-c2cc(-c3ccncc3)c3n(c2=O)CCCc2ccncc2-3)n1 | Homo sapiens | CHEMBL2327956 | single protein format |
| CHEMBL306422 |  |
Ki | = | 0.61 | nM | 362.35 | Cc1cc(-c2nnc3c4ccccc4c(OCc4cn(C)nn4)nn23)no1 | Homo sapiens | CHEMBL4403719 | single protein format |
| CHEMBL373250 |  |
Ki | = | 0.7 | nM | 399.41 | Cn1ncnc1COc1nn2c(-c3cc(F)ccc3F)nnc2cc1C(C)(C)C | Homo sapiens | CHEMBL2327956 | single protein format |
| CHEMBL363211 |  |
Ki | = | 0.8 | nM | 368.4 | Cc1cc(-c2nncc3c(C(C)(C)C)c(OCc4ncnn4C)nn23)no1 | Homo sapiens | CHEMBL2327956 | single protein format |
| CHEMBL301605 |  |
Ki | = | 1.0 | nM | 257.3 | c1ccc2c(c1)[nH]c1c2ncc2[nH]c3ccccc3c21 | Homo sapiens | CHEMBL5235569 | single protein format |
| CHEMBL1783282 |  |
Ki | = | 1.3 | nM | 354.39 | CCCNC(=O)c1nnc2c(-c3c(F)cccc3OC)cccc2c1N | Homo sapiens | CHEMBL4403719 | single protein format |
| CHEMBL204696 |  |
Ki | = | 1.8 | nM | 391.38 | CC(C)(O)c1cnn2c(-c3ccc(F)c(-c4c(F)cccc4C#N)c3)cnc2n1 | Homo sapiens | CHEMBL4403719 | single protein format |
| CHEMBL49141 |  |
Ki | = | 2.0 | nM | 342.4 | CCCOc1ccc2[nH]c3cnc(C(=O)OCC)c(COC)c3c2c1 | Homo sapiens | CHEMBL5235569 | single protein format |
| CHEMBL5280240 |  |
Ki | = | 2.0 | nM | 314.34 | CCOC(=O)c1ncc2[nH]c3ccc(OC)cc3c2c1COC | Homo sapiens | CHEMBL5235569 | single protein format |
| CHEMBL1783256 |  |
Ki | = | 3.1 | nM | 366.42 | CCCNC(=O)c1nnc2c(-c3cc(OC)ccc3OC)cccc2c1N | Homo sapiens | CHEMBL4403719 | single protein format |
| CHEMBL5290579 |  |
Ki | = | 4.0 | nM | 328.37 | CCc1c(C(=O)OC)nc(C)c2[nH]c3cc(OC)c(OC)cc3c12 | Homo sapiens | CHEMBL5235569 | single protein format |
| CHEMBL5275690 |  |
Ki | = | 4.0 | nM | 342.4 | CCOC(=O)c1nc(C)c2[nH]c3cc(OC)c(OC)cc3c2c1CC | Homo sapiens | CHEMBL5235569 | single protein format |
| CHEMBL454095 |  |
Ki | = | 4.0 | nM | 404.47 | COCc1c(C(=O)OC(C)C)ncc2[nH]c3ccc(OCc4ccccc4)cc3c12 | Homo sapiens | CHEMBL5235569 | single protein format |
| CHEMBL5266498 |  |
Ki | = | 5.0 | nM | 284.31 | CCOC(=O)c1ncc2[nH]c3ccccc3c2c1COC | Homo sapiens | CHEMBL5235569 | single protein format |
| CHEMBL1518572 |  |
Ki | = | 6.0 | nM | 390.44 | CCOC(=O)c1ncc2[nH]c3ccc(OCc4ccccc4)cc3c2c1COC | Homo sapiens | CHEMBL5235569 | single protein format |
| CHEMBL454606 |  |
Ki | = | 6.0 | nM | 240.26 | CCOC(=O)c1cc2c(cn1)[nH]c1ccccc12 | Homo sapiens | CHEMBL5235569 | single protein format |
| CHEMBL6597 |  |
Ki | = | 7.0 | nM | 326.32 | CCOC(=O)c1ncn2c1CN(C)C(=O)c1cc(N=[N+]=[N-])ccc1-2 | Homo sapiens | CHEMBL5341720 | single protein format |
| CHEMBL5290464 |  |
Ki | = | 11.0 | nM | 300.31 | CCOC(=O)c1ncc2[nH]c3ccc(O)cc3c2c1COC | Homo sapiens | CHEMBL5235569 | single protein format |