P34897 | GLYM_HUMAN | Serine hydroxymethyltransferase, mitochondrial (SHMT2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00464 | SHMT - Serine hydroxymethyltransferase | 49~448 |
3D structures mapped by conservation among orthologs
[ Domain: "C-terminal domain in some PLP-dependent transferases" // SHMT ]
[ Domain: "PLP-dependent transferases" // Aminotran_5_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4530254 |  |
IC50 | = | 540.0 | nM | 375.25 | COc1ccc(-c2nc3c4nsnc4ccc3n2C)cc1Br | Homo sapiens | CHEMBL4418848 | assay format |
| CHEMBL582132 |  |
IC50 | = | 690.0 | nM | 357.37 | CCOc1cc(-c2nnc3[nH]c(=O)n(C)c(=O)c3n2)ccc1OC(C)C | Homo sapiens | CHEMBL4418848 | assay format |
| CHEMBL1528232 |  |
IC50 | = | 710.0 | nM | 268.36 | CCOC(=O)CSc1nc2ccc(N)cc2s1 | Homo sapiens | CHEMBL4418848 | assay format |
| CHEMBL4555669 |  |
IC50 | = | 850.0 | nM | 375.5 | Cn1nc(C(=O)N2CC=C(c3ccccc3)CC2)c2c1-c1ccsc1CC2 | Homo sapiens | CHEMBL4418848 | assay format |
| CHEMBL5440815 |  |
Ki | = | 16.0 | nM | 487.49 | Nc1nc2ccn(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365104 | assay format |
| CHEMBL5429283 |  |
Ki | = | 60.0 | nM | 475.53 | Nc1nc2ccn(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365104 | assay format |
| CHEMBL5438587 |  |
Ki | = | 80.0 | nM | 469.5 | Nc1nc2ccn(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365104 | assay format |
| CHEMBL5431881 |  |
Ki | = | 340.0 | nM | 441.44 | Nc1nc2ccn(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365104 | assay format |
| CHEMBL5405010 |  |
Ki | = | 450.0 | nM | 473.46 | Nc1nc2ccn(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365104 | assay format |
| CHEMBL5408906 |  |
Ki | = | 460.0 | nM | 459.43 | Nc1nc2ccn(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365104 | assay format |
| CHEMBL5427804 |  |
Ki | = | 630.0 | nM | 479.49 | Nc1nc2ccn(CCCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3F)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365104 | assay format |
| CHEMBL5431331 |  |
Ki | = | 650.0 | nM | 457.44 | Nc1nc2ccn(CCCOc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365104 | assay format |