P34896 | GLYC_HUMAN | Serine hydroxymethyltransferase, cytosolic (SHMT1)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00464 | SHMT | 26–425 |
3D structures mapped by conservation among orthologs
[ Domain: "C-terminal domain in some PLP-dependent transferases" // SHMT ]
[ Domain: "PLP-dependent transferases" // Aminotran_5_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL5438587 | Ki | = | 60.0 | nM | 469.5 | Nc1nc2ccn(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365103 | assay format | |
CHEMBL5429283 | Ki | = | 120.0 | nM | 475.53 | Nc1nc2ccn(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365103 | assay format | |
CHEMBL5440815 | Ki | = | 220.0 | nM | 487.49 | Nc1nc2ccn(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365103 | assay format | |
CHEMBL5408906 | Ki | = | 790.0 | nM | 459.43 | Nc1nc2ccn(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365103 | assay format | |
CHEMBL5431881 | Ki | = | 900.0 | nM | 441.44 | Nc1nc2ccn(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL5365103 | assay format |