P34896 | GLYC_HUMAN | Serine hydroxymethyltransferase, cytosolic (SHMT1)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00464SHMT26–425

 3D structures mapped by conservation among orthologs

[ Domain: "C-terminal domain in some PLP-dependent transferases" // SHMT ]

 PyMOL session

[ Domain: "PLP-dependent transferases" // Aminotran_5_N ]

 PyMOL session


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5438587 Ki = 60.0 nM 469.5 Nc1nc2ccn(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 Homo sapiens CHEMBL5365103 assay format
CHEMBL5429283 Ki = 120.0 nM 475.53 Nc1nc2ccn(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 Homo sapiens CHEMBL5365103 assay format
CHEMBL5440815 Ki = 220.0 nM 487.49 Nc1nc2ccn(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)c2c(=O)[nH]1 Homo sapiens CHEMBL5365103 assay format
CHEMBL5408906 Ki = 790.0 nM 459.43 Nc1nc2ccn(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)c2c(=O)[nH]1 Homo sapiens CHEMBL5365103 assay format
CHEMBL5431881 Ki = 900.0 nM 441.44 Nc1nc2ccn(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 Homo sapiens CHEMBL5365103 assay format