P33527 | MRP1_HUMAN | Multidrug resistance-associated protein 1 (ABCC1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00005 | ABC_tran - ABC transporter | 661~795 | |
| PF00005 | ABC_tran - ABC transporter | 1310~1458 | |
| PF00664 | ABC_membrane - ABC transporter transmembrane region | 326~596 | |
| PF00664 | ABC_membrane - ABC transporter transmembrane region | 976~1242 | |
| PF24357 | TMD0_ABC - ABC transporter TMD0 domain | 25~160 |
3D structures mapped by conservation among orthologs
[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // ABC_tran_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL58 |  |
IC50 | = | 27.5 | nM | 444.49 | O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21 | Homo sapiens | CHEMBL4322537 | cell-based format |
| CHEMBL27007 |  |
IC50 | = | 33.0 | nM | 422.48 | Cc1nccc2c1c1ncnc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c1n2C | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL27102 |  |
IC50 | = | 43.0 | nM | 590.68 | COc1cccc(CNC(=O)c2c3n(c4c(N5CCN(CCc6ccc(F)c(F)c6)CC5)ncnc24)CCCC3)c1OC | Homo sapiens | CHEMBL714116 | assay format |
| CHEMBL430724 |  |
IC50 | = | 44.0 | nM | 408.46 | Cn1c2ccncc2c2ncnc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c21 | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL26485 |  |
IC50 | = | 61.0 | nM | 531.61 | O=C(NCc1ccccn1)c1c2n(c3c(N4CCN(CCc5ccc(F)c(F)c5)CC4)ncnc13)CCCC2 | Homo sapiens | CHEMBL714116 | assay format |
| CHEMBL26678 |  |
IC50 | = | 62.0 | nM | 450.49 | Cn1c2cccc(C(N)=O)c2c2ncnc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c21 | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL28629 |  |
IC50 | = | 71.0 | nM | 493.56 | Cn1c2ccnc(N3CCOCC3)c2c2ncnc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c21 | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL280981 |  |
IC50 | = | 76.0 | nM | 517.58 | O=C(Nc1cccnc1)c1c2n(c3c(N4CCN(CCc5ccc(F)c(F)c5)CC4)ncnc13)CCCC2 | Homo sapiens | CHEMBL714116 | assay format |
| CHEMBL27191 |  |
IC50 | = | 78.0 | nM | 468.46 | COc1ccc2[nH]c3c(N4CCN(CCc5ccc(F)c(F)c5)CC4)ncnc3c2c1[N+](=O)[O-] | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL6966 |  |
IC50 | = | 79.0 | nM | 454.61 | COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC | Homo sapiens | CHEMBL5334219 | cell-based format |
| CHEMBL29743 |  |
IC50 | = | 80.0 | nM | 529.55 | O=[N+]([O-])c1cccc2c1c1ncnc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c1n2Cc1ccncc1 | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL26686 |  |
IC50 | = | 87.0 | nM | 442.9 | Cn1c2cc(Cl)ncc2c2ncnc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c21 | Homo sapiens | CHEMBL714751 | assay format |
| CHEMBL26779 |  |
IC50 | = | 88.0 | nM | 510.51 | Cc1nc2c(c(C(N)=O)c1[N+](=O)[O-])c1ncnc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c1n2C | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL418382 |  |
IC50 | = | 90.0 | nM | 542.03 | Cn1c2ccnc(Cl)c2c2nc(CN3CCOCC3)nc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c21 | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL281496 |  |
IC50 | = | 97.0 | nM | 550.61 | Cn1c2nccc(C(N)=O)c2c2nc(CN3CCOCC3)nc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c21 | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL26635 |  |
IC50 | = | 105.0 | nM | 499.57 | N#Cc1c2n(c3c(N4CCN(CCc5ccc(F)c(F)c5)CC4)nc(-c4ccncc4)nc13)CCCC2 | Homo sapiens | CHEMBL714116 | assay format |
| CHEMBL281326 |  |
IC50 | = | 106.0 | nM | 514.58 | Cn1c2ccnc(NCc3ccccn3)c2c2ncnc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c21 | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL25903 |  |
IC50 | = | 110.0 | nM | 451.48 | Cn1c2nccc(C(N)=O)c2c2ncnc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c21 | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL27257 |  |
IC50 | = | 113.0 | nM | 451.48 | COC(=O)c1ccc2[nH]c3c(N4CCN(CCc5ccc(F)c(F)c5)CC4)ncnc3c2c1 | Homo sapiens | CHEMBL714115 | assay format |
| CHEMBL25731 |  |
IC50 | = | 115.0 | nM | 437.5 | CNc1nccc2c1c1ncnc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c1n2C | Homo sapiens | CHEMBL714115 | assay format |