P33261 | CP2CJ_HUMAN | Cytochrome P450 2C19 (CYP2C19)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00067 | p450 - Cytochrome P450 | 30~487 |
3D structures mapped by conservation among orthologs
[ Domain: "Cytochrome P450" // p450 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL112532 |  |
IC50 | = | 7.0 | nM | 216.28 | CCCCOc1ccc(-n2ccnc2)cc1 | Homo sapiens | CHEMBL664322 | single protein format |
| CHEMBL104 |  |
IC50 | = | 16.0 | nM | 344.85 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | Homo sapiens | CHEMBL1909134 | cell-based format |
| CHEMBL998 |  |
IC50 | = | 16.0 | nM | 382.89 | CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 | Homo sapiens | CHEMBL1909134 | cell-based format |
| CHEMBL1221 |  |
IC50 | = | 16.0 | nM | 397.76 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | Homo sapiens | CHEMBL1909134 | cell-based format |
| CHEMBL91 |  |
IC50 | = | 16.0 | nM | 416.13 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | Homo sapiens | CHEMBL1909134 | cell-based format |
| CHEMBL3898132 |  |
IC50 | = | 30.0 | nM | 453.35 | Cn1cc(-c2nc3c(N4CCN(Cc5cccnc5)CC4)c(Br)cnc3[nH]2)cn1 | Homo sapiens | CHEMBL3889070 | single protein format |
| CHEMBL3891461 |  |
IC50 | = | 30.0 | nM | 481.4 | Cc1nn(C)c(C)c1-c1nc2c(N3CCN(Cc4cccnc4)CC3)c(Br)cnc2[nH]1 | Homo sapiens | CHEMBL3889070 | single protein format |
| CHEMBL2207503 |  |
IC50 | = | 30.0 | nM | 456.38 | Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4ccc(Cl)cc4)CC3)c(Cl)cnc2[nH]1 | Homo sapiens | CHEMBL3889070 | single protein format |
| CHEMBL2207500 |  |
IC50 | = | 30.0 | nM | 413.87 | Cc1nn(C)cc1-c1nc2c(N3CCN(Cc4ncon4)CC3)c(Cl)cnc2[nH]1 | Homo sapiens | CHEMBL3889070 | single protein format |
| CHEMBL808 |  |
IC50 | = | 40.0 | nM | 381.69 | Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | Homo sapiens | CHEMBL1909134 | cell-based format |
| CHEMBL1262 |  |
IC50 | = | 40.0 | nM | 429.13 | Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 | Homo sapiens | CHEMBL1909134 | cell-based format |
| CHEMBL151280 |  |
IC50 | < | 46.0 | nM | 227.31 | CCCCOc1ccc(-c2ccncc2)cc1 | Homo sapiens | CHEMBL664322 | single protein format |
| CHEMBL358216 |  |
IC50 | < | 46.0 | nM | 217.27 | CCCCOc1ccc(-c2cnco2)cc1 | Homo sapiens | CHEMBL664322 | single protein format |
| CHEMBL358880 |  |
IC50 | < | 46.0 | nM | 230.31 | CCCCOc1ccc(-n2cncc2C)cc1 | Homo sapiens | CHEMBL664322 | single protein format |
| CHEMBL151354 |  |
IC50 | < | 46.0 | nM | 233.34 | CCCCOc1ccc(-c2ccns2)cc1 | Homo sapiens | CHEMBL664322 | single protein format |
| CHEMBL2079587 |  |
IC50 | = | 48.0 | nM | 328.5 | C[C@]12Cc3c[nH]nc3C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O | Homo sapiens | CHEMBL1909134 | cell-based format |
| CHEMBL345544 |  |
IC50 | = | 68.0 | nM | 217.27 | CCCCOc1ccc(-n2cncn2)cc1 | Homo sapiens | CHEMBL664322 | single protein format |
| CHEMBL1909048 |  |
IC50 | = | 200.0 | nM | 313.83 | O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL1909134 | cell-based format |
| CHEMBL348263 |  |
IC50 | = | 270.0 | nM | 208.26 | CCCCOc1ccc(N/C=N\O)cc1 | Homo sapiens | CHEMBL664322 | single protein format |
| CHEMBL267865 |  |
IC50 | = | 272.0 | nM | 206.29 | CCCCc1ccc(/N=C/NO)c(C)c1 | Homo sapiens | CHEMBL664322 | single protein format |