P33121 | ACSL1_HUMAN | Long-chain-fatty-acid--CoA ligase 1 (ACSL1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00501 | AMP-binding - AMP-binding enzyme | 116~520 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4764916 |  |
IC50 | = | 3.0 | nM | 448.5 | Cn1c(Cc2ccc3c(c2)OCC3)nc2cc(O[C@H]3CC[C@@](F)(c4nnn[nH]4)CC3)ccc21 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4750346 |  |
IC50 | = | 13.0 | nM | 420.49 | Cc1cccc(Cc2nc3cc(O[C@H]4CC[C@@](F)(c5nnn[nH]5)CC4)ccc3n2C)c1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4746996 |  |
IC50 | = | 13.0 | nM | 406.48 | Cn1c(Cc2ccc3c(c2)OCC3)nc2cc(O[C@H]3CC[C@@H](C(=O)O)CC3)ccc21 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4787746 |  |
IC50 | = | 28.0 | nM | 412.92 | Cc1cccc(Cc2nc3cc(O[C@H]4CC[C@@H](C(=O)O)CC4)cc(Cl)c3n2C)c1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4749130 |  |
IC50 | = | 34.0 | nM | 402.5 | Cc1cccc(Cc2nc3cc(O[C@H]4CC[C@@H](c5nnn[nH]5)CC4)ccc3n2C)c1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4781788 |  |
IC50 | = | 39.0 | nM | 365.43 | Cc1cccc(Cc2nc3cc(O[C@H]4CC[C@@H](C(=O)O)CC4)ccc3o2)c1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4778736 |  |
IC50 | = | 42.0 | nM | 378.47 | Cc1cccc(Cc2nc3cc(O[C@H]4CC[C@@H](C(=O)O)CC4)ccc3n2C)c1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4797544 |  |
IC50 | = | 44.0 | nM | 379.46 | Cc1cccc(Cc2nc3nc(O[C@H]4CC[C@@H](C(=O)O)CC4)ccc3n2C)c1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4755109 |  |
IC50 | = | 45.0 | nM | 378.47 | Cc1cccc(Cn2nc3cc(O[C@H]4CC[C@@H](C(=O)O)CC4)ccc3c2C)c1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4748671 |  |
IC50 | = | 47.0 | nM | 418.5 | Cc1cccc(Cc2nc3cc(O[C@H]4CC[C@@H](c5noc(=O)[nH]5)CC4)ccc3n2C)c1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4740366 |  |
IC50 | = | 47.0 | nM | 412.92 | Cc1cccc(Cc2nc3cc(O[C@H]4CC[C@@H](C(=O)O)CC4)c(Cl)cc3n2C)c1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4783346 |  |
IC50 | = | 150.0 | nM | 378.47 | Cc1ccc(Cc2nc3cc(O[C@H]4CC[C@@H](C(=O)O)CC4)ccc3n2C)cc1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4800541 |  |
IC50 | = | 190.0 | nM | 432.44 | Cn1c(Cc2cccc(C(F)(F)F)c2)nc2cc(O[C@H]3CC[C@@H](C(=O)O)CC3)ccc21 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4761388 |  |
IC50 | = | 240.0 | nM | 338.36 | O=c1c2ccccc2oc2ccc(O[C@H]3CC[C@@H](C(=O)O)CC3)cc12 | Homo sapiens | CHEMBL4678700 | single protein format |
| CHEMBL4757253 |  |
IC50 | = | 240.0 | nM | 338.36 | O=c1c2ccccc2oc2ccc(O[C@H]3CC[C@H](C(=O)O)CC3)cc12 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4776019 |  |
IC50 | = | 310.0 | nM | 340.38 | O=C(O)CCCCCCOc1ccc2oc3ccccc3c(=O)c2c1 | Homo sapiens | CHEMBL4678700 | single protein format |
| CHEMBL4757057 |  |
IC50 | = | 400.0 | nM | 377.48 | Cc1cccc(Cc2cc3cc(O[C@H]4CC[C@@H](C(=O)O)CC4)ccc3n2C)c1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4748493 |  |
IC50 | = | 600.0 | nM | 420.51 | Cc1cccc(Cc2c(C(N)=O)c3cc(O[C@H]4CC[C@@H](C(=O)O)CC4)ccc3n2C)c1 | Homo sapiens | CHEMBL4678699 | single protein format |
| CHEMBL4751045 |  |
IC50 | = | 950.0 | nM | 377.49 | Cc1cccc(Cc2nc3cc(O[C@H]4CC[C@@H](C(N)=O)CC4)ccc3n2C)c1 | Homo sapiens | CHEMBL4678699 | single protein format |