P33032 | MC5R_HUMAN | Melanocortin receptor 5 (MC5R)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 53~295 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL220018 |  |
IC50 | = | 0.1 | nM | 543.72 | N=C(N)NCCC[C@H](NC(=O)CCc1c[nH]c2ccccc12)C(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 | Homo sapiens | CHEMBL908723 | cell-based format |
| CHEMBL425442 |  |
IC50 | = | 0.1 | nM | 458.61 | O=C(CCC(=O)N1C[C@@H]2CCCN2C[C@H]1Cc1ccccc1)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL908723 | cell-based format |
| CHEMBL218558 |  |
IC50 | = | 0.4 | nM | 500.69 | O=C(CCc1c[nH]c2ccccc12)NCCCCCC(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 | Homo sapiens | CHEMBL908723 | cell-based format |
| CHEMBL218361 |  |
IC50 | = | 0.5 | nM | 458.61 | O=C(CCC(=O)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL908723 | cell-based format |
| CHEMBL387169 |  |
IC50 | = | 0.8 | nM | 387.53 | O=C(CCc1c[nH]c2ccccc12)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccccc1 | Homo sapiens | CHEMBL908723 | cell-based format |
| CHEMBL3968918 |  |
IC50 | = | 9.0 | nM | 599.22 | O=C(/C=C/c1ccc(Cl)cc1)NC[C@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@@H](CCN2CCCCC2)N1 | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3916418 |  |
IC50 | < | 10.0 | nM | 575.63 | CC[C@H](CN1CC[C@H](CNC(=O)c2ccc(Cl)c(Cl)c2)N[C@H](CCN(C(C)C)C(C)C)C1=O)c1ccccc1 | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3922209 |  |
IC50 | < | 10.0 | nM | 595.62 | CC[C@H](CN1CC[C@H](CNC(=O)c2ccc(Cl)c(Cl)c2)N[C@H](CCN(C)Cc2ccccc2)C1=O)c1ccccc1 | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3972031 |  |
IC50 | < | 10.0 | nM | 585.19 | O=C(/C=C/c1ccc(Cl)cc1)NC[C@@H]1CCN(CC(c2ccccc2)c2ccccc2)C(=O)[C@H](CN2CCCCC2)N1 | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3925258 |  |
IC50 | < | 10.0 | nM | 589.58 | O=C(/C=C/c1ccc(Br)cc1)NC[C@H]1CCN(c2ccc3ccccc3c2)C(=O)[C@@H](CCN2CCCCC2)N1 | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3911231 |  |
IC50 | < | 10.0 | nM | 563.19 | CC[C@H](CN1CC[C@H](CNC(=O)c2ccc3cc(Cl)ccc3c2)N[C@H](CCNCC(C)C)C1=O)c1ccccc1 | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3918644 |  |
IC50 | < | 10.0 | nM | 591.2 | CC[C@H](CN1CC[C@H](CNC(=O)c2ccc3cc(Cl)ccc3c2)N[C@H](CCNC(=N)NC(C)C)C1=O)c1ccccc1 | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3973100 |  |
IC50 | < | 10.0 | nM | 575.97 | CC(C)NCC[C@H]1N[C@@H](CNC(=O)c2ccc3cc(Cl)ccc3c2)CCN(Cc2cc(Cl)cc(Cl)c2)C1=O | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3889499 |  |
IC50 | < | 10.0 | nM | 539.16 | C=C(C)[C@@H](CC)CN1CC[C@H](CNC(=O)c2ccc3cc(Cl)ccc3c2)N[C@H](CCN2CCCCC2)C1=O | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3983023 |  |
IC50 | < | 10.0 | nM | 525.14 | CC[C@@H](CN1CC[C@@H](CNC(=O)c2ccc(Cl)cc2)N[C@@H](CCN2CCCCC2)C1=O)c1ccccc1 | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3902730 |  |
IC50 | < | 10.0 | nM | 559.58 | CC[C@H](CN1CC[C@H](CNC(=O)c2ccc(Cl)cc2Cl)N[C@H](CCN2CCCCC2)C1=O)c1ccccc1 | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3929195 |  |
IC50 | < | 10.0 | nM | 590.77 | CNC(=N)NCCC[C@@H]1N[C@H](CNC(=O)c2ccc3ccccc3c2)CCN(CC(c2ccccc2)c2ccccc2)C1=O | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3954379 |  |
IC50 | < | 10.0 | nM | 586.39 | O=C(NC[C@H]1CCN(Cc2cc(Cl)cc(Cl)c2)C(=O)[C@@H](CCN2CCCCC2)N1)c1ccc(Cl)cc1Cl | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3983098 |  |
IC50 | < | 10.0 | nM | 575.2 | CC[C@@H](CN1CC[C@H](CNC(=O)c2ccc3cc(Cl)ccc3c2)N[C@H](CCN2CCCCC2)C1=O)c1ccccc1 | Homo sapiens | CHEMBL3888445 | assay format |
| CHEMBL3978574 |  |
IC50 | < | 10.0 | nM | 573.61 | CC[C@H](CN1CC[C@H](CNC(=O)c2ccc(Cl)c(Cl)c2)N[C@H](CCN2CCCC[C@@H]2C)C1=O)c1ccccc1 | Homo sapiens | CHEMBL3888445 | assay format |