P32754 | HPPD_HUMAN | 4-hydroxyphenylpyruvate dioxygenase (HPD)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00903 | Glyoxalase - Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily | 19~123 | |
| PF00903 | Glyoxalase - Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily | 181~301 |
3D structures mapped by conservation among orthologs
[ Domain: "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase" // PLN02875 ]
[ Domain: "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase" // Glyoxalase_10 ]
[ Domain: "Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase" // Glyoxalase_4_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3408320 |  |
IC50 | = | 21.0 | nM | 314.35 | CCn1c(=O)n(CC)c2cc(C(=O)c3cnn(C)c3O)ccc21 | Homo sapiens | CHEMBL3412604 | assay format |
| CHEMBL3408319 |  |
IC50 | = | 22.0 | nM | 328.37 | CCCn1c(=O)n(CC)c2ccc(C(=O)c3cnn(C)c3O)cc21 | Homo sapiens | CHEMBL3412604 | assay format |
| CHEMBL3408314 |  |
IC50 | = | 22.0 | nM | 300.32 | CCn1c(=O)n(C)c2ccc(C(=O)c3cnn(C)c3O)cc21 | Homo sapiens | CHEMBL3412604 | assay format |
| CHEMBL3408324 |  |
IC50 | = | 39.0 | nM | 328.37 | CCCn1c(=O)n(CC)c2cc(C(=O)c3cnn(C)c3O)ccc21 | Homo sapiens | CHEMBL3412604 | assay format |
| CHEMBL3408325 |  |
IC50 | = | 40.0 | nM | 342.4 | CCCn1c(=O)n(CCC)c2cc(C(=O)c3cnn(C)c3O)ccc21 | Homo sapiens | CHEMBL3412604 | assay format |
| CHEMBL4533679 |  |
IC50 | = | 47.0 | nM | 446.25 | O=C1CCCC(O)=C1C(=O)c1cccc(OCc2ccc(Br)cc2)c1[N+](=O)[O-] | Homo sapiens | CHEMBL4481032 | assay format |
| CHEMBL3408157 |  |
IC50 | = | 59.0 | nM | 314.35 | CCCn1c(=O)n(C)c2ccc(C(=O)c3cnn(C)c3O)cc21 | Homo sapiens | CHEMBL3412604 | assay format |
| CHEMBL3408313 |  |
IC50 | = | 61.0 | nM | 314.35 | CC(C)n1c(=O)n(C)c2ccc(C(=O)c3cnn(C)c3O)cc21 | Homo sapiens | CHEMBL3412604 | assay format |
| CHEMBL4526579 |  |
IC50 | = | 63.0 | nM | 436.25 | O=C1CCCC(O)=C1C(=O)c1cccc(OCc2ccc(Cl)cc2Cl)c1[N+](=O)[O-] | Homo sapiens | CHEMBL4481032 | assay format |
| CHEMBL3408321 |  |
IC50 | = | 64.0 | nM | 328.37 | CCn1c(=O)n(C(C)C)c2cc(C(=O)c3cnn(C)c3O)ccc21 | Homo sapiens | CHEMBL3412604 | assay format |
| CHEMBL4564855 |  |
IC50 | = | 68.0 | nM | 464.24 | O=C1CCCC(O)=C1C(=O)c1cccc(OCc2ccc(Br)cc2F)c1[N+](=O)[O-] | Homo sapiens | CHEMBL4481032 | assay format |
| CHEMBL4582009 |  |
IC50 | = | 68.0 | nM | 395.41 | Cc1cc(C)cc(COc2cccc(C(=O)C3=C(O)CCCC3=O)c2[N+](=O)[O-])c1 | Homo sapiens | CHEMBL4481032 | assay format |
| CHEMBL3408156 |  |
IC50 | = | 68.0 | nM | 331.25 | CCC(=O)C(C(C)=O)C(=O)c1ccc(C(F)(F)F)cc1[N+](=O)[O-] | Homo sapiens | CHEMBL3412604 | assay format |
| CHEMBL4571726 |  |
IC50 | = | 70.0 | nM | 409.44 | CC(C)c1ccc(COc2cccc(C(=O)C3=C(O)CCCC3=O)c2[N+](=O)[O-])cc1 | Homo sapiens | CHEMBL4481032 | assay format |
| CHEMBL4540372 |  |
IC50 | = | 70.0 | nM | 381.38 | Cc1ccc(COc2cccc(C(=O)C3=C(O)CCCC3=O)c2[N+](=O)[O-])cc1 | Homo sapiens | CHEMBL4481032 | assay format |
| CHEMBL3408326 |  |
IC50 | = | 77.0 | nM | 356.43 | CCCn1c(=O)n(C(C)(C)C)c2cc(C(=O)c3cnn(C)c3O)ccc21 | Homo sapiens | CHEMBL3412604 | assay format |
| CHEMBL4567229 |  |
IC50 | = | 85.0 | nM | 329.23 | O=C1CCCC(O)=C1C(=O)c1ccc(C(F)(F)F)cc1[N+](=O)[O-] | Homo sapiens | CHEMBL4481032 | assay format |
| CHEMBL4554387 |  |
IC50 | = | 91.0 | nM | 401.26 | O=C1CCCC(O)=C1C(=O)c1cccc(OCc2ccc(Br)cc2)c1 | Homo sapiens | CHEMBL4481032 | assay format |
| CHEMBL4564283 |  |
IC50 | = | 95.0 | nM | 403.34 | O=C1CCCC(O)=C1C(=O)c1cccc(OCc2ccc(F)cc2F)c1[N+](=O)[O-] | Homo sapiens | CHEMBL4481032 | assay format |
| CHEMBL3408315 |  |
IC50 | = | 100.0 | nM | 328.37 | Cn1ncc(C(=O)c2ccc3c(c2)n(C(C)(C)C)c(=O)n3C)c1O | Homo sapiens | CHEMBL3412604 | assay format |