P32418 | NAC1_HUMAN | Sodium/calcium exchanger 1 (SLC8A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01699 | Na_Ca_ex - Sodium/calcium exchanger protein | 81~250 | |
| PF01699 | Na_Ca_ex - Sodium/calcium exchanger protein | 800~962 | |
| PF03160 | Calx-beta - Calx-beta domain | 533~635 | |
| PF16494 | Na_Ca_ex_C - C-terminal extension of sodium/calcium exchanger domain | 254~389 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3662020 |  |
IC50 | = | 70.0 | nM | 490.47 | Cc1ccccc1[C@@H]1CCc2cc(Oc3ncc(C(=O)NCCOP(=O)(O)O)s3)ccc2O1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3662028 |  |
IC50 | = | 92.0 | nM | 433.49 | O=C(NCc1ccno1)c1csc(Oc2ccc3c(c2)CC[C@@H](c2ccccc2)O3)n1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3661987 |  |
IC50 | = | 100.0 | nM | 382.49 | OCCNCc1cnc(Oc2ccc3c(c2)CCC(c2ccccc2)O3)s1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3657700 |  |
IC50 | = | 100.0 | nM | 451.48 | O=C(NCc1ccno1)c1cnc(Oc2ccc3c(c2)CCC(c2cccc(F)c2)O3)s1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3657801 |  |
IC50 | = | 100.0 | nM | 419.51 | c1ccc(C2CCc3cc(Oc4ncc(CNCc5ccno5)s4)ccc3O2)cc1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3657680 |  |
IC50 | = | 100.0 | nM | 486.6 | CN(C)c1cc(CNC(=O)c2cnc(Oc3ccc4c(c3)CCC(c3ccccc3)O4)s2)ccn1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3661945 |  |
IC50 | = | 100.0 | nM | 382.49 | OCCNCc1cnc(Oc2ccc3c(c2)CC[C@@H](c2ccccc2)O3)s1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3661858 |  |
IC50 | = | 100.0 | nM | 433.49 | O=C(NCc1ccno1)c1cnc(Oc2ccc3c(c2)CC[C@@H](c2ccccc2)O3)s1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3657710 |  |
IC50 | = | 100.0 | nM | 449.56 | O=C(NCc1ccncc1)c1cnc(Oc2ccc3c(c2)CCC(c2ccsc2)O3)s1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3657687 |  |
IC50 | = | 100.0 | nM | 443.53 | O=C(NCc1ccncc1)c1cnc(Oc2ccc3c(c2)CC[C@@H](c2ccccc2)O3)s1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3662043 |  |
IC50 | = | 100.0 | nM | 338.43 | NCc1cnc(Oc2ccc3c(c2)CCC(c2ccccc2)O3)s1 | Homo sapiens | CHEMBL3705520 | cell-based format |
| CHEMBL3657709 |  |
IC50 | = | 100.0 | nM | 457.56 | Cc1nc(Oc2ccc3c(c2)CCC(c2ccccc2)O3)sc1C(=O)NCc1ccncc1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3661925 |  |
IC50 | = | 100.0 | nM | 410.5 | COC(=O)CNCc1cnc(Oc2ccc3c(c2)CC[C@@H](c2ccccc2)O3)s1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3661894 |  |
IC50 | = | 100.0 | nM | 419.51 | c1ccc([C@@H]2CCc3cc(Oc4ncc(CNCc5ccno5)s4)ccc3O2)cc1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3661888 |  |
IC50 | = | 100.0 | nM | 396.47 | O=C(NCCO)c1cnc(Oc2ccc3c(c2)CC[C@@H](c2ccccc2)O3)s1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3657696 |  |
IC50 | = | 100.0 | nM | 475.55 | O=C(Cc1cccnc1)NCc1cnc(Oc2ccc3c(c2)CCC(c2cccc(F)c2)O3)s1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3657698 |  |
IC50 | = | 100.0 | nM | 479.58 | O=S(=O)(NCc1cnc(Oc2ccc3c(c2)CCC(c2ccccc2)O3)s1)c1cccnc1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3657699 |  |
IC50 | = | 100.0 | nM | 433.49 | O=C(NCc1cnc(Oc2ccc3c(c2)CCC(c2ccccc2)O3)s1)c1ccno1 | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3661988 |  |
IC50 | = | 100.0 | nM | 440.52 | O=C(c1cnc(Oc2ccc3c(c2)CCC(c2ccccc2)O3)s1)N(CCO)CCO | Homo sapiens | CHEMBL3705519 | cell-based format |
| CHEMBL3657672 |  |
IC50 | = | 100.0 | nM | 458.54 | Cc1nccc(CNC(=O)c2cnc(Oc3ccc4c(c3)CCC(c3ccccc3)O4)s2)n1 | Homo sapiens | CHEMBL3705519 | cell-based format |