P32247 | BRS3_HUMAN | Bombesin receptor subtype-3 (BRS3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 64~328 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2023112 |  |
IC50 | = | 0.5 | nM | 574.5 | CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | Homo sapiens | CHEMBL2027395 | cell-based format |
| CHEMBL2023113 |  |
IC50 | = | 0.5 | nM | 586.51 | NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1 | Homo sapiens | CHEMBL2027395 | cell-based format |
| CHEMBL2179918 |  |
IC50 | = | 0.7 | nM | 512.56 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1 | Homo sapiens | CHEMBL2182521 | cell-based format |
| CHEMBL2164581 |  |
IC50 | = | 0.7 | nM | 559.57 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1 | Homo sapiens | CHEMBL2168755 | cell-based format |
| CHEMBL2164577 |  |
IC50 | = | 0.76 | nM | 541.6 | Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1 | Homo sapiens | CHEMBL2168755 | cell-based format |
| CHEMBL2179911 |  |
IC50 | = | 0.9 | nM | 475.54 | Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | Homo sapiens | CHEMBL2182521 | cell-based format |
| CHEMBL2164223 |  |
IC50 | = | 0.9 | nM | 587.62 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | Homo sapiens | CHEMBL2168755 | cell-based format |
| CHEMBL2164580 |  |
IC50 | = | 1.1 | nM | 529.54 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1 | Homo sapiens | CHEMBL2168755 | cell-based format |
| CHEMBL2164582 |  |
IC50 | = | 1.2 | nM | 573.6 | C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | Homo sapiens | CHEMBL2168755 | cell-based format |
| CHEMBL2179908 |  |
IC50 | = | 1.2 | nM | 456.01 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2 | Homo sapiens | CHEMBL2182521 | cell-based format |
| CHEMBL2164578 |  |
IC50 | = | 1.4 | nM | 544.64 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1 | Homo sapiens | CHEMBL2168755 | cell-based format |
| CHEMBL2179473 |  |
IC50 | = | 1.6 | nM | 475.54 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2 | Homo sapiens | CHEMBL2182521 | cell-based format |
| CHEMBL2164224 |  |
IC50 | = | 1.7 | nM | 573.6 | CC(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1 | Homo sapiens | CHEMBL2168755 | cell-based format |
| CHEMBL2164576 |  |
IC50 | = | 1.72 | nM | 538.6 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1 | Homo sapiens | CHEMBL2168755 | cell-based format |
| CHEMBL2164222 |  |
IC50 | = | 1.9 | nM | 573.6 | C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1 | Homo sapiens | CHEMBL2168755 | cell-based format |
| CHEMBL2179916 |  |
IC50 | = | 2.2 | nM | 477.51 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1 | Homo sapiens | CHEMBL2182521 | cell-based format |
| CHEMBL2179912 |  |
IC50 | = | 3.2 | nM | 495.95 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1 | Homo sapiens | CHEMBL2182521 | cell-based format |
| CHEMBL2179476 |  |
IC50 | = | 3.3 | nM | 517.45 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2 | Homo sapiens | CHEMBL2182521 | cell-based format |
| CHEMBL2179907 |  |
IC50 | = | 4.4 | nM | 446.58 | Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2 | Homo sapiens | CHEMBL2182521 | cell-based format |
| CHEMBL2179915 |  |
IC50 | = | 5.0 | nM | 537.58 | CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1 | Homo sapiens | CHEMBL2182521 | cell-based format |