P32246 | CCR1_HUMAN | C-C chemokine receptor type 1 (CCR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 51~301 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4128926 |  |
IC50 | = | 0.081 | nM | 583.78 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | Homo sapiens | CHEMBL4121481 | single protein format |
| CHEMBL519240 |  |
IC50 | = | 0.087 | nM | 327.43 | Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 | Homo sapiens | CHEMBL947352 | single protein format |
| CHEMBL4464625 |  |
IC50 | = | 0.3 | nM | 453.5 | CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | Homo sapiens | CHEMBL4332214 | cell-based format |
| CHEMBL2332933 |  |
IC50 | = | 0.36 | nM | 432.47 | CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | Homo sapiens | CHEMBL2340879 | cell-based format |
| CHEMBL3099947 |  |
IC50 | = | 0.63 | nM | 471.53 | O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)NC1CC1 | Homo sapiens | CHEMBL3102090 | cell-based format |
| CHEMBL2332931 |  |
IC50 | = | 0.64 | nM | 448.92 | CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | Homo sapiens | CHEMBL2340879 | cell-based format |
| CHEMBL3679659 |  |
IC50 | = | 0.7 | nM | 494.08 | C[C@H](NC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O | Homo sapiens | CHEMBL3705351 | single protein format |
| CHEMBL2332940 |  |
IC50 | = | 0.79 | nM | 445.95 | CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | Homo sapiens | CHEMBL2340879 | cell-based format |
| CHEMBL3099945 |  |
IC50 | = | 0.89 | nM | 487.98 | O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1 | Homo sapiens | CHEMBL3102090 | cell-based format |
| CHEMBL331897 |  |
IC50 | = | 0.9 | nM | 528.54 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | Homo sapiens | CHEMBL650697 | single protein format |
| CHEMBL2332930 |  |
IC50 | = | 0.9 | nM | 460.96 | COc1ccc(NC(C)=O)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 | Homo sapiens | CHEMBL2340879 | cell-based format |
| CHEMBL2391803 |  |
IC50 | = | 0.92 | nM | 537.44 | O=C(c1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 | Homo sapiens | CHEMBL2396023 | cell-based format |
| CHEMBL2332932 |  |
IC50 | = | 0.96 | nM | 430.93 | CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | Homo sapiens | CHEMBL2340879 | cell-based format |
| CHEMBL2332934 |  |
IC50 | = | 0.96 | nM | 414.48 | CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | Homo sapiens | CHEMBL2340879 | cell-based format |
| CHEMBL3334818 |  |
IC50 | = | 1.0 | nM | 472.03 | CC(C)[C@@H](NC(=O)NCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | Homo sapiens | CHEMBL3366538 | cell-based format |
| CHEMBL3679651 |  |
IC50 | = | 1.0 | nM | 534.08 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(S(N)(=O)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL3705351 | single protein format |
| CHEMBL2398717 |  |
IC50 | = | 1.0 | nM | 420.98 | CC(C)[C@@H](NC(=O)CC1CC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | Homo sapiens | CHEMBL2399021 | single protein format |
| CHEMBL3334824 |  |
IC50 | = | 1.0 | nM | 454.01 | CC(C)[C@@H](NC(=O)NCC(C)(C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | Homo sapiens | CHEMBL3366538 | cell-based format |
| CHEMBL2391810 |  |
IC50 | = | 1.1 | nM | 517.02 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCC(O)CC1 | Homo sapiens | CHEMBL2396023 | cell-based format |
| CHEMBL2398728 |  |
IC50 | = | 1.1 | nM | 451.01 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | Homo sapiens | CHEMBL2398869 | single protein format |