P31644 | GBRA5_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02931 | Neur_chan_LBD - Neurotransmitter-gated ion-channel ligand binding domain | 50~257 | |
| PF02932 | Neur_chan_memb - Neurotransmitter-gated ion-channel transmembrane region | 264~445 |
3D structures mapped by conservation among orthologs
[ Domain: "Nicotinic receptor ligand binding domain-like" // Neur_chan_LBD ]
[ Domain: "Neurotransmitter-gated ion-channel transmembrane pore" // Neur_chan_memb ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL73416 |  |
IC50 | = | 2.7 | nM | 341.84 | CCCC(=O)N(C)Cc1c(-c2ccc(Cl)cc2)nc2ccccn12 | Homo sapiens | CHEMBL677202 | tissue-based format |
| CHEMBL3652873 |  |
IC50 | = | 100.0 | nM | 365.39 | CC1=NN=C(c2cc3ccc(F)cc3s2)c2cc3oc(=O)[nH]c3cc2C1 | Homo sapiens | CHEMBL3705380 | cell-based format |
| CHEMBL3652869 |  |
IC50 | = | 130.0 | nM | 347.4 | CC1=NN=C(c2cc3ccccc3s2)c2cc3oc(=O)[nH]c3cc2C1 | Homo sapiens | CHEMBL3705380 | cell-based format |
| CHEMBL3652871 |  |
IC50 | = | 200.0 | nM | 365.39 | CC1=NN=C(c2cc3c(F)cccc3s2)c2cc3oc(=O)[nH]c3cc2C1 | Homo sapiens | CHEMBL3705380 | cell-based format |
| CHEMBL2008708 |  |
IC50 | = | 200.0 | nM | 258.28 | c1ccc2c(c1)[nH]c1cnc3c4cccnc4[nH]c3c12 | Homo sapiens | CHEMBL5235585 | single protein format |
| CHEMBL458144 |  |
IC50 | = | 210.0 | nM | 368.95 | CSC1SC(C(=O)c2ccc(Cl)cc2)C2CC(C)(C)CC(=O)C12 | Homo sapiens | CHEMBL991889 | cell-based format |
| CHEMBL5281056 |  |
IC50 | = | 240.0 | nM | 258.28 | c1ccc2c(c1)[nH]c1cnc3c4ccncc4[nH]c3c12 | Homo sapiens | CHEMBL5235585 | single protein format |
| CHEMBL3652870 |  |
IC50 | = | 250.0 | nM | 449.84 | CC1=NN=C(c2sc3cccc(C(F)(F)F)c3c2Cl)c2cc3oc(=O)[nH]c3cc2C1 | Homo sapiens | CHEMBL3705380 | cell-based format |
| CHEMBL3652872 |  |
IC50 | = | 500.0 | nM | 415.4 | CC1=NN=C(c2cc3c(C(F)(F)F)cccc3s2)c2cc3oc(=O)[nH]c3cc2C1 | Homo sapiens | CHEMBL3705380 | cell-based format |
| CHEMBL511684 |  |
IC50 | = | 550.0 | nM | 340.9 | CSC1SC(C(=O)c2ccc(Cl)cc2)C2CCCC(=O)C12 | Homo sapiens | CHEMBL991889 | cell-based format |
| CHEMBL461925 |  |
IC50 | = | 1000.0 | nM | 287.77 | Nc1c(C(=O)c2ccc(Cl)cc2)sc2ccccc12 | Homo sapiens | CHEMBL991889 | cell-based format |
| CHEMBL3681588 |  |
Ki | = | 0.1 | nM | 388.81 | Cc1onc(-c2ccc(Cl)cn2)c1COC(O)Cc1ccc(C(N)=O)cn1 | Homo sapiens | CHEMBL3705480 | single protein format |
| CHEMBL3681586 |  |
Ki | = | 0.2 | nM | 426.78 | Cc1onc(-c2ccc(Cl)cn2)c1COC(c1ccc(C(N)=O)cn1)C(F)(F)F | Homo sapiens | CHEMBL3705480 | single protein format |
| CHEMBL3676436 |  |
Ki | = | 0.3 | nM | 376.43 | Cc1onc(C2CCC(F)CN2)c1COc1ccc(C(=O)NC(C)C)cn1 | Homo sapiens | CHEMBL3705480 | single protein format |
| CHEMBL3676421 |  |
Ki | = | 0.3 | nM | 410.33 | Cc1onc(-c2ccc(F)cn2)c1COc1ccc(C(=O)NCC(F)(F)F)cn1 | Homo sapiens | CHEMBL3705480 | single protein format |
| CHEMBL3676425 |  |
Ki | = | 0.3 | nM | 386.84 | Cc1onc(-c2ccc(Cl)cn2)c1COc1ccc(C(=O)NC(C)C)cn1 | Homo sapiens | CHEMBL3705480 | single protein format |
| CHEMBL3681585 |  |
Ki | = | 0.3 | nM | 398.85 | Cc1onc(-c2ccc(Cl)cn2)c1COC(c1ccc(C(N)=O)cn1)C1CC1 | Homo sapiens | CHEMBL3705480 | single protein format |
| CHEMBL3676426 |  |
Ki | = | 0.3 | nM | 384.82 | Cc1onc(-c2ccc(Cl)cn2)c1COc1ccc(C(=O)NC2CC2)cn1 | Homo sapiens | CHEMBL3705480 | single protein format |
| CHEMBL3676424 |  |
Ki | = | 0.3 | nM | 428.88 | Cc1onc(-c2ccc(Cl)cn2)c1COc1ccc(C(=O)NC2CCOCC2)cn1 | Homo sapiens | CHEMBL3705480 | single protein format |
| CHEMBL5268764 |  |
Ki | = | 0.3 | nM | 348.36 | CCOC(=O)c1ncn2c1c(=O)n(Cc1cccnc1)c1ccccc12 | Homo sapiens | CHEMBL5240509 | single protein format |