P31639 | SC5A2_HUMAN | Sodium/glucose cotransporter 2 (SLC5A2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00474 | SSF - Sodium:solute symporter family | 55~492 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1164052 |  |
IC50 | = | 0.3 | nM | 460.95 | C#CCOCc1cc(Cl)c(Cc2ccc(CC)cc2)cc1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL1167866 | cell-based format |
| CHEMBL565781 |  |
IC50 | = | 0.3 | nM | 476.83 | OC[C@H]1O[C@]2(OCc3cc(Cl)c(Cc4ccc(OC(F)(F)F)cc4)cc32)[C@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL1050643 | cell-based format |
| CHEMBL3703868 |  |
IC50 | = | 0.308 | nM | 454.97 | CCOc1ccc(Cc2cc([C@@H]3O[C@H](SC)[C@@H](O)[C@H](O)[C@H]3O)cc(OC)c2Cl)cc1 | Homo sapiens | CHEMBL3705440 | assay format |
| CHEMBL5288495 |  |
IC50 | = | 0.35 | nM | 412.86 | CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)C(F)(F)[C@H](O)[C@H]3O)ccc2Cl)cc1 | Homo sapiens | CHEMBL5258239 | single protein format |
| CHEMBL3941422 |  |
IC50 | = | 0.366 | nM | 448.9 | OC[C@@H]1O[C@H](c2cc(Cc3ccc(C4CC4)cc3)c(Cl)c3c2OCO3)[C@@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL3705440 | assay format |
| CHEMBL3985666 |  |
IC50 | = | 0.366 | nM | 432.9 | C=Cc1ccc(Cc2cc([C@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)c3c(c2Cl)OCC3)cc1 | Homo sapiens | CHEMBL3705440 | assay format |
| CHEMBL3703908 |  |
IC50 | = | 0.37 | nM | 448.9 | OC[C@H]1O[C@@H](c2cc(Cc3ccc(C4CC4)cc3)c(Cl)c3c2OCO3)[C@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL3888404 | assay format |
| CHEMBL3703920 |  |
IC50 | = | 0.37 | nM | 432.9 | C=Cc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3c(c2Cl)OCC3)cc1 | Homo sapiens | CHEMBL3888404 | assay format |
| CHEMBL3703912 |  |
IC50 | = | 0.4 | nM | 436.89 | CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3c(c2Cl)OCO3)cc1 | Homo sapiens | CHEMBL3888404 | assay format |
| CHEMBL3978611 |  |
IC50 | = | 0.404 | nM | 436.89 | CCc1ccc(Cc2cc([C@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)c3c(c2Cl)OCO3)cc1 | Homo sapiens | CHEMBL3705440 | assay format |
| CHEMBL3703785 |  |
IC50 | = | 0.44 | nM | 479.37 | COc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3c(c2Br)CCC3)cc1 | Homo sapiens | CHEMBL3888404 | assay format |
| CHEMBL3703855 |  |
IC50 | = | 0.454 | nM | 454.93 | CS[C@H]1O[C@@H](c2cc(Cc3ccc4c(c3)OCCO4)c(Cl)cc2O)[C@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL3705440 | assay format |
| CHEMBL3703921 |  |
IC50 | = | 0.463 | nM | 446.93 | OC[C@H]1O[C@@H](c2cc(Cc3ccc(C4CC4)cc3)c(Cl)c3c2CCO3)[C@H](O)[C@@H](O)[C@@H]1O | Homo sapiens | CHEMBL3705440 | assay format |
| CHEMBL4114400 |  |
IC50 | = | 0.47 | nM | 468.96 | COc1ccc(Cc2cc([C@@H]3O[C@H](SO)[C@@H](O)[C@H](O)[C@H]3O)c3c(c2Cl)CCCO3)cc1 | Homo sapiens | CHEMBL3888404 | assay format |
| CHEMBL3703870 |  |
IC50 | = | 0.475 | nM | 447.96 | CN(C)c1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3c(c2Cl)CCC3)cc1 | Homo sapiens | CHEMBL3705440 | assay format |
| CHEMBL4111780 |  |
IC50 | = | 0.49 | nM | 468.96 | CCOc1ccc(Cc2cc([C@@H]3O[C@H](SC)[C@@H](O)[C@H](O)[C@H]3O)c3c(c2Cl)OCO3)cc1 | Homo sapiens | CHEMBL3888404 | assay format |
| CHEMBL4112174 |  |
IC50 | = | 0.49 | nM | 446.97 | CCc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3c(c2Cl)CCCC3)cc1 | Homo sapiens | CHEMBL3888404 | assay format |
| CHEMBL4113334 |  |
IC50 | = | 0.5 | nM | 450.98 | COc1ccc(Cc2cc([C@@H]3O[C@H](SC)[C@@H](O)[C@H](O)[C@H]3O)c3c(c2Cl)CCC3)cc1 | Homo sapiens | CHEMBL3888404 | assay format |
| CHEMBL4297625 |  |
IC50 | = | 0.5 | nM | 416.47 | CCc1ccc([C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1Cc1ccc2c(c1)OCCO2 | Homo sapiens | CHEMBL4727639 | single protein format |
| CHEMBL3703864 |  |
IC50 | = | 0.504 | nM | 466.98 | C=CCOc1cc(Cl)c(Cc2ccc(OC)cc2)cc1[C@@H]1O[C@H](SC)[C@@H](O)[C@H](O)[C@H]1O | Homo sapiens | CHEMBL3705440 | assay format |