P31391 | SSR4_HUMAN | Somatostatin receptor type 4 (SSTR4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 64~311 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL473160 |  |
IC50 | = | 2.4 | nM | 590.6 | COC(=O)[C@H](CCCCN)N1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)Cc2ccccc2)C1=O.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL1009181 | cell-based format |
| CHEMBL227212 |  |
IC50 | = | 3.3 | nM | 551.69 | NCCCC[C@@H](C(=O)NCc1ccccc1)N1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)Cc2ccccc2)C1=O | Homo sapiens | CHEMBL888502 | single protein format |
| CHEMBL1450103 |  |
IC50 | = | 4.2 | nM | 485.54 | COC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCc1c(-c2ccccc2)[nH]c2c(F)cc(F)cc12 | Homo sapiens | CHEMBL807045 | single protein format |
| CHEMBL501699 |  |
IC50 | = | 7.0 | nM | 589.61 | CC(=O)N[C@@H]1Cc2c([nH]c3ccccc23)CN([C@@H](CCCCN)C(=O)NCc2ccccc2)C1=O.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL1009181 | cell-based format |
| CHEMBL93351 |  |
IC50 | = | 41.0 | nM | 554.76 | NCCCC1CCCN2C(=O)[C@@H](Cc3c[nH]c4ccccc34)SCCN(Cc3cccc4ccccc34)C(=O)C12 | Homo sapiens | CHEMBL801249 | single protein format |
| CHEMBL388069 |  |
IC50 | = | 75.0 | nM | 418.54 | NCCCCCN1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)Cc2ccccc2)C1=O | Homo sapiens | CHEMBL888502 | single protein format |
| CHEMBL227211 |  |
IC50 | = | 129.0 | nM | 508.67 | NCCCCCN1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)CC(c2ccccc2)c2ccccc2)C1=O | Homo sapiens | CHEMBL888502 | single protein format |
| CHEMBL1254882 |  |
IC50 | = | 180.0 | nM | 552.7 | CS[C@@H]1O[C@H](COCc2ccccc2)[C@@H](O)[C@@H](OCc2ccc3ccccc3c2)[C@H]1NC(=O)CCN=C(N)N | Homo sapiens | CHEMBL1252086 | cell-based format |
| CHEMBL2204935 |  |
IC50 | = | 384.0 | nM | 494.53 | Cc1nc([C@]2(c3cnn(C)c3)N[C@@H](c3nc(-c4ccc(F)cc4)c[nH]3)Cc3c2[nH]c2ccccc32)no1 | Homo sapiens | CHEMBL2208679 | cell-based format |
| CHEMBL1254967 |  |
IC50 | = | 430.0 | nM | 545.1 | CS[C@@H]1O[C@H](COCc2ccc(Cl)cc2)[C@@H](O)[C@@H](OCc2ccc3ccccc3c2)[C@H]1NC(=O)CCN | Homo sapiens | CHEMBL1252086 | cell-based format |
| CHEMBL1255049 |  |
IC50 | = | 440.0 | nM | 560.72 | CS[C@@H]1O[C@H](COCc2ccc3ccccc3c2)[C@@H](O)[C@@H](OCc2ccc3ccccc3c2)[C@H]1NC(=O)CCN | Homo sapiens | CHEMBL1252086 | cell-based format |
| CHEMBL1253788 |  |
IC50 | = | 660.0 | nM | 510.66 | CS[C@@H]1O[C@H](COCc2ccccc2)[C@@H](O)[C@@H](OCc2ccc3ccccc3c2)[C@H]1NC(=O)CCN | Homo sapiens | CHEMBL1252086 | cell-based format |
| CHEMBL5183772 |  |
Ki | = | 0.5 | nM | 426.52 | COc1cccc(Cc2nnc(Cc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)c1 | Homo sapiens | CHEMBL5137205 | cell membrane format |
| CHEMBL5174969 |  |
Ki | = | 0.5 | nM | 448.93 | Fc1ccc2c(Cc3nnc(Cc4cccc(Cl)c4)n3CCCc3c[nH]cn3)c[nH]c2c1 | Homo sapiens | CHEMBL5137205 | cell membrane format |
| CHEMBL5197201 |  |
Ki | = | 0.5 | nM | 430.94 | Clc1cccc(Cc2nnc(Cc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)c1 | Homo sapiens | CHEMBL5137205 | cell membrane format |
| CHEMBL5185547 |  |
Ki | = | 0.6 | nM | 444.51 | COc1cccc(Cc2nnc(Cc3c[nH]c4cc(F)ccc34)n2CCCc2c[nH]cn2)c1 | Homo sapiens | CHEMBL5137205 | cell membrane format |
| CHEMBL1450103 | |
Ki | = | 0.7 | nM | 485.54 | COC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCc1c(-c2ccccc2)[nH]c2c(F)cc(F)cc12 | Homo sapiens | CHEMBL4369234 | cell-based format |
| CHEMBL5175637 |  |
Ki | = | 0.7 | nM | 471.52 | Fc1ccc2c(Cc3nnc(Cc4c[nH]c5cc(F)ccc45)n3CCCc3c[nH]cn3)c[nH]c2c1 | Homo sapiens | CHEMBL5137205 | cell membrane format |
| CHEMBL5172814 |  |
Ki | = | 0.7 | nM | 492.58 | CS(=O)(=O)c1cccc(Cc2nnc(Cc3c[nH]c4cc(F)ccc34)n2CCCc2c[nH]cn2)c1 | Homo sapiens | CHEMBL5137205 | cell membrane format |
| CHEMBL5193727 |  |
Ki | = | 0.7 | nM | 482.49 | Fc1ccc2c(Cc3nnc(Cc4cccc(C(F)(F)F)c4)n3CCCc3c[nH]cn3)c[nH]c2c1 | Homo sapiens | CHEMBL5137205 | cell membrane format |