P31327 | CPSM_HUMAN | Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00117 | GATase - Glutamine amidotransferase class-I | 222~395 | |
| PF00988 | CPSase_sm_chain - Carbamoyl-phosphate synthase small chain, CPSase domain | 48~183 | |
| PF02142 | MGS - MGS-like domain | 1375~1465 | |
| PF02786 | CPSase_L_D2 - Carbamoyl-phosphate synthase L chain, ATP binding domain | 546~749 | |
| PF02786 | CPSase_L_D2 - Carbamoyl-phosphate synthase L chain, ATP binding domain | 1088~1290 | |
| PF02787 | CPSase_L_D3 - Carbamoyl-phosphate synthetase large chain, oligomerisation domain | 841~920 | |
| PF25596 | CPSase_L_D1 - Carbamoyl phosphate synthase preATP-grasp domain | 423~542 | |
| PF25596 | CPSase_L_D1 - Carbamoyl phosphate synthase preATP-grasp domain | 974~1084 |
3D structures mapped by conservation among orthologs
[ Domain: "winged" // CPSase_L_D3 ]
[ Domain: "ATP-grasp" // ATP-grasp ]
[ Domain: "PreATP-grasp domain" // carB ]
[ Domain: "Class I glutamine amidotransferase-like" // GATase ]
[ Domain: "The "swivelling" beta/beta/alpha domain" // CPSase_sm_chain ]
[ Domain: "Methylglyoxal synthase-like" // MGS ]
[ Domain: "Methylglyoxal synthase-like" // MGS,EUF08629 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4649653 |  |
IC50 | = | 66.0 | nM | 409.46 | COc1ccc(C(=O)N2[C@H](C)CN(C(=O)c3ccc4cc[nH]c4c3)C[C@H]2C)c(F)c1 | Homo sapiens | CHEMBL4619220 | cell-based format |
| CHEMBL4649844 |  |
IC50 | = | 130.0 | nM | 432.47 | CCOc1ccc(C(=O)N2C[C@@H](C)N(C(=O)c3ccc(OC)cc3F)[C@H](C)C2)c(F)c1 | Homo sapiens | CHEMBL4619220 | cell-based format |
| CHEMBL4638888 |  |
IC50 | = | 170.0 | nM | 423.49 | COc1ccc(C(=O)N2[C@H](C)CN(C(=O)c3ccc4cc(C)[nH]c4c3)C[C@H]2C)c(F)c1 | Homo sapiens | CHEMBL4619220 | cell-based format |
| CHEMBL4636473 |  |
IC50 | = | 360.0 | nM | 418.44 | COc1ccc(C(=O)N2C[C@@H](C)N(C(=O)c3ccc(OC)cc3F)[C@H](C)C2)c(F)c1 | Homo sapiens | CHEMBL4619220 | cell-based format |
| CHEMBL4634845 |  |
IC50 | = | 360.0 | nM | 402.44 | COc1ccc(C(=O)N2C[C@@H](C)N(C(=O)c3ccc(C)cc3F)[C@H](C)C2)c(F)c1 | Homo sapiens | CHEMBL4619220 | cell-based format |
| CHEMBL4644019 |  |
IC50 | = | 380.0 | nM | 432.47 | CCOc1ccc(C(=O)N2[C@H](C)CN(C(=O)c3ccc(OC)cc3F)C[C@H]2C)c(F)c1 | Homo sapiens | CHEMBL4619220 | cell-based format |
| CHEMBL4634332 |  |
IC50 | = | 540.0 | nM | 418.44 | COc1ccc(C(=O)N2[C@H](C)CN(C(=O)c3ccc(OC)c(F)c3)C[C@H]2C)c(F)c1 | Homo sapiens | CHEMBL4619220 | cell-based format |