P31327 | CPSM_HUMAN | Carbamoyl-phosphate synthase [ammonia], mitochondrial (CPS1)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00117GATase222–395
PF00988CPSase_sm_chain48–183
PF02142MGS1375–1465
PF02786CPSase_L_D2546–749
PF02786CPSase_L_D21088–1290
PF02787CPSase_L_D3841–920
PF25596CPSase_L_D1423–542
PF25596CPSase_L_D1974–1084

 3D structures mapped by conservation among orthologs

[ Domain: "winged" // CPSase_L_D3 ]

 PyMOL session

[ Domain: "ATP-grasp" // ATP-grasp ]

 PyMOL session

[ Domain: "PreATP-grasp domain" // carB ]

 PyMOL session

[ Domain: "Class I glutamine amidotransferase-like" // GATase ]

 PyMOL session

[ Domain: "The "swivelling" beta/beta/alpha domain" // CPSase_sm_chain ]

 PyMOL session

[ Domain: "Methylglyoxal synthase-like" // MGS ]

 PyMOL session

[ Domain: "Methylglyoxal synthase-like" // MGS,EUF08629 ]

 PyMOL session


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4649653 IC50 = 66.0 nM 409.46 COc1ccc(C(=O)N2[C@H](C)CN(C(=O)c3ccc4cc[nH]c4c3)C[C@H]2C)c(F)c1 Homo sapiens CHEMBL4619220 cell-based format
CHEMBL4649844 IC50 = 130.0 nM 432.47 CCOc1ccc(C(=O)N2C[C@@H](C)N(C(=O)c3ccc(OC)cc3F)[C@H](C)C2)c(F)c1 Homo sapiens CHEMBL4619220 cell-based format
CHEMBL4638888 IC50 = 170.0 nM 423.49 COc1ccc(C(=O)N2[C@H](C)CN(C(=O)c3ccc4cc(C)[nH]c4c3)C[C@H]2C)c(F)c1 Homo sapiens CHEMBL4619220 cell-based format
CHEMBL4636473 IC50 = 360.0 nM 418.44 COc1ccc(C(=O)N2C[C@@H](C)N(C(=O)c3ccc(OC)cc3F)[C@H](C)C2)c(F)c1 Homo sapiens CHEMBL4619220 cell-based format
CHEMBL4634845 IC50 = 360.0 nM 402.44 COc1ccc(C(=O)N2C[C@@H](C)N(C(=O)c3ccc(C)cc3F)[C@H](C)C2)c(F)c1 Homo sapiens CHEMBL4619220 cell-based format
CHEMBL4644019 IC50 = 380.0 nM 432.47 CCOc1ccc(C(=O)N2[C@H](C)CN(C(=O)c3ccc(OC)cc3F)C[C@H]2C)c(F)c1 Homo sapiens CHEMBL4619220 cell-based format
CHEMBL4634332 IC50 = 540.0 nM 418.44 COc1ccc(C(=O)N2[C@H](C)CN(C(=O)c3ccc(OC)c(F)c3)C[C@H]2C)c(F)c1 Homo sapiens CHEMBL4619220 cell-based format