P31153 | METK2_HUMAN | S-adenosylmethionine synthase isoform type-2 (MAT2A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00438 | S-AdoMet_synt_N - S-adenosylmethionine synthetase, N-terminal domain | 18~115 | |
| PF02772 | S-AdoMet_synt_M - S-adenosylmethionine synthetase, central domain | 130~250 | |
| PF02773 | S-AdoMet_synt_C - S-adenosylmethionine synthetase, C-terminal domain | 252~388 |
3D structures mapped by conservation among orthologs
[ Domain: "S-adenosylmethionine synthetase" // S-AdoMet_synt_C ]
[ Domain: "S-adenosylmethionine synthetase" // S-AdoMet_synt_M ]
[ Domain: "S-adenosylmethionine synthetase" // S-AdoMet_synt_N ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4521249 |  |
IC50 | = | 4.0 | nM | 499.58 | O=c1c(-c2ccc3ncccc3c2)c(Nc2cc[nH]n2)[nH]c2c(C3=CCCCC3)c(-c3ccccc3)nn12 | Homo sapiens | CHEMBL4835540 | cell-based format |
| CHEMBL4552959 |  |
IC50 | = | 4.0 | nM | 569.58 | CCOC(=O)c1nnc(Nc2[nH]c3c(-c4ccccc4)c(-c4ccccc4)nn3c(=O)c2-c2ccc3ncccc3c2)o1 | Homo sapiens | CHEMBL4835540 | cell-based format |
| CHEMBL5199008 |  |
IC50 | = | 4.7 | nM | 578.62 | CCOc1ncc2cc(C3=CC4N=C(CCN5CCC(O)C5)N(C)C4C=C3)c(=O)n(-c3ccc(OC(F)F)cc3)c2n1 | Homo sapiens | CHEMBL5141069 | single protein format |
| CHEMBL4558617 |  |
IC50 | = | 5.0 | nM | 478.56 | COc1ccc(-c2c(Nc3cc[nH]n3)[nH]c3c(C4=CCCCC4)c(-c4ccccc4)nn3c2=O)cc1 | Homo sapiens | CHEMBL4835540 | cell-based format |
| CHEMBL4514699 |  |
IC50 | = | 7.0 | nM | 460.5 | O=c1c(-c2ccc(O)cc2)c(Nc2cc[nH]n2)[nH]c2c(-c3ccccc3)c(-c3ccccc3)nn12 | Homo sapiens | CHEMBL4835540 | cell-based format |
| CHEMBL4568226 |  |
IC50 | = | 7.0 | nM | 485.55 | COc1ccc(-c2c(Nc3ccccn3)[nH]c3c(-c4ccccc4)c(-c4ccccc4)nn3c2=O)cc1 | Homo sapiens | CHEMBL4835540 | cell-based format |
| CHEMBL4582312 |  |
IC50 | = | 7.0 | nM | 495.55 | O=c1c(-c2ccc3ncccc3c2)c(Nc2cc[nH]n2)[nH]c2c(-c3ccccc3)c(-c3ccccc3)nn12 | Homo sapiens | CHEMBL4835540 | cell-based format |
| CHEMBL4860456 |  |
IC50 | = | 8.0 | nM | 239.28 | Cc1cc(=O)n2nc(C)c(-c3ccccc3)c2[nH]1 | Homo sapiens | CHEMBL5141066 | cell-based format |
| CHEMBL4870597 |  |
IC50 | = | 8.0 | nM | 428.49 | Cc1[nH]c2c(N3CCCCC3)c(-c3ccccc3)nn2c(=O)c1-c1ccc2c(c1)OCO2 | Homo sapiens | CHEMBL4835540 | cell-based format |
| CHEMBL5185760 |  |
IC50 | = | 10.0 | nM | 429.91 | CCNc1ccc2cn(-c3ccc4nn(C)cc4c3)c(=O)c(-c3ccc(Cl)cc3)c2n1 | Homo sapiens | CHEMBL5161737 | cell-based format |
| CHEMBL4585665 |  |
IC50 | = | 10.0 | nM | 479.54 | COc1ccc(-c2c(Nc3ccon3)[nH]c3c(C4=CCCCC4)c(-c4ccccc4)nn3c2=O)cc1 | Homo sapiens | CHEMBL4835540 | cell-based format |
| CHEMBL4584451 |  |
IC50 | = | 11.0 | nM | 546.59 | CCOC(=O)n1ccc(Nc2[nH]c3c(-c4ccccc4)c(-c4ccccc4)nn3c(=O)c2-c2ccc(OC)cc2)n1 | Homo sapiens | CHEMBL4835540 | cell-based format |
| CHEMBL5177250 |  |
IC50 | = | 11.0 | nM | 483.88 | Cn1cc2cc(-n3cc4ccc(NCC(F)(F)F)nc4c(-c4ccc(Cl)cc4)c3=O)ccc2n1 | Homo sapiens | CHEMBL5161737 | cell-based format |
| CHEMBL5187048 |  |
IC50 | = | 13.0 | nM | 466.88 | Cn1cc2cc(-n3cc4ccc(OCC(F)F)nc4c(-c4ccc(Cl)cc4)c3=O)ccc2n1 | Homo sapiens | CHEMBL5161737 | cell-based format |
| CHEMBL4559088 |  |
IC50 | = | 13.0 | nM | 474.52 | COc1ccc(-c2c(Nc3cc[nH]n3)[nH]c3c(-c4ccccc4)c(-c4ccccc4)nn3c2=O)cc1 | Homo sapiens | CHEMBL4835540 | cell-based format |
| CHEMBL5078281 |  |
IC50 | = | 13.0 | nM | 313.79 | CCN(C)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12 | Homo sapiens | CHEMBL5036615 | assay format |
| CHEMBL5399738 |  |
IC50 | = | 14.0 | nM | 514.54 | CN1CCn2c(nc3ccc(-c4cc5cnc(C6CC6)nc5n(-c5ccc(OC(F)F)cc5)c4=O)cc32)C1 | Homo sapiens | CHEMBL5383988 | cell-based format |
| CHEMBL4573938 |  |
IC50 | = | 14.0 | nM | 489.58 | COc1ccc(-c2c(Nc3ccccn3)[nH]c3c(C4=CCCCC4)c(-c4ccccc4)nn3c2=O)cc1 | Homo sapiens | CHEMBL4835540 | cell-based format |
| CHEMBL5178902 |  |
IC50 | = | 14.0 | nM | 484.87 | Cn1cc2cc(-n3cc4cnc(NCC(F)(F)F)nc4c(-c4ccc(Cl)cc4)c3=O)ccc2n1 | Homo sapiens | CHEMBL5161737 | cell-based format |
| CHEMBL5415073 |  |
IC50 | = | 14.0 | nM | 517.54 | CCNc1ncc2cc(-c3ccc4nc5n(c4c3)CCN(C)C5)c(=O)n(-c3ccc(OC(F)F)cc3)c2n1 | Homo sapiens | CHEMBL5383988 | cell-based format |