P30939 | 5HT1F_HUMAN | 5-hydroxytryptamine receptor 1F (HTR1F)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 41~347 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4851044 |  |
IC50 | = | 0.32 | nM | 379.36 | CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | Homo sapiens | CHEMBL4830576 | single protein format |
| CHEMBL101690 |  |
Ki | = | 1.6 | nM | 351.43 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 | Homo sapiens | CHEMBL616729 | single protein format |
| CHEMBL128636 |  |
Ki | = | 1.6 | nM | 351.43 | CN1CCC(c2c[nH]c3cccc(NC(=O)c4ccc(F)cc4)c23)CC1 | Homo sapiens | CHEMBL616726 | single protein format |
| CHEMBL361303 |  |
Ki | = | 2.2 | nM | 351.42 | CN1CCC(n2ccc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | Homo sapiens | CHEMBL827882 | single protein format |
| CHEMBL3039520 |  |
Ki | = | 2.21 | nM | 377.37 | CN1CCC(C(=O)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | Homo sapiens | CHEMBL5110035 | single protein format |
| CHEMBL173949 |  |
Ki | = | 2.3 | nM | 389.38 | CN1CCC(c2coc3ccc(NC(=O)c4c(F)cc(F)cc4F)nc23)CC1 | Homo sapiens | CHEMBL616729 | single protein format |
| CHEMBL323264 |  |
Ki | = | 2.5 | nM | 287.37 | CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | Homo sapiens | CHEMBL616730 | assay format |
| CHEMBL606556 |  |
Ki | = | 2.7 | nM | 403.94 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12 | Homo sapiens | CHEMBL829046 | cell-based format |
| CHEMBL369705 |  |
Ki | = | 2.9 | nM | 387.84 | CN1CCC(c2coc3ccc(NC(=O)c4c(F)cccc4Cl)nc23)CC1 | Homo sapiens | CHEMBL616729 | single protein format |
| CHEMBL177238 |  |
Ki | = | 3.0 | nM | 387.84 | CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4Cl)nc23)CC1 | Homo sapiens | CHEMBL616729 | single protein format |
| CHEMBL177258 |  |
Ki | = | 3.1 | nM | 353.4 | CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | Homo sapiens | CHEMBL616729 | single protein format |
| CHEMBL187308 |  |
Ki | = | 3.6 | nM | 387.84 | CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4Cl)cc23)CC1 | Homo sapiens | CHEMBL827882 | single protein format |
| CHEMBL421287 |  |
Ki | = | 3.8 | nM | 325.39 | CN(C)CCc1c[nH]c2cccc(NC(=O)c3ccc(F)cc3)c12 | Homo sapiens | CHEMBL616726 | single protein format |
| CHEMBL102292 |  |
Ki | = | 3.8 | nM | 301.39 | CCNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | Homo sapiens | CHEMBL616730 | assay format |
| CHEMBL184597 |  |
Ki | = | 3.9 | nM | 352.41 | CN1CCC(c2n[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 | Homo sapiens | CHEMBL827882 | single protein format |
| CHEMBL92139 |  |
Ki | = | 3.9 | nM | 328.44 | CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 | Homo sapiens | CHEMBL616724 | cell-based format |
| CHEMBL104496 |  |
Ki | = | 4.1 | nM | 403.31 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(Cl)cc4Cl)nc23)CC1 | Homo sapiens | CHEMBL616730 | assay format |
| CHEMBL365405 |  |
Ki | = | 4.1 | nM | 352.41 | CN1CCC(n2ncc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | Homo sapiens | CHEMBL827882 | single protein format |
| CHEMBL102250 |  |
Ki | = | 4.6 | nM | 324.38 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1 | Homo sapiens | CHEMBL616730 | assay format |
| CHEMBL105556 |  |
Ki | = | 4.7 | nM | 309.39 | CN1CCC(c2c[nH]c3ccc(OS(C)(=O)=O)nc23)CC1 | Homo sapiens | CHEMBL616730 | assay format |