P30874 | SSR2_HUMAN | Somatostatin receptor type 2 (SSTR2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 60~312 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4206924 |  |
IC50 | = | 0.2 | nM | 581.76 | CCOc1ccc(CN(C)C)cc1NC(=O)[C@H](NC(=O)N1CCC(c2ccccc2)CC1)[C@@H](C)c1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4179566 | cell-based format |
| CHEMBL4211422 |  |
IC50 | = | 0.6 | nM | 587.77 | CCOc1ccc(CN(C)C)cc1NC(=O)[C@H](NC(=O)N1CCC(C(=O)C2CCC2)CC1)[C@@H](C)c1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4179566 | cell-based format |
| CHEMBL4215053 |  |
IC50 | = | 0.69 | nM | 585.75 | CC(=O)c1ccc(CN(C)C)cc1NC(=O)[C@H](NC(=O)N1CCC(C(=O)C2CCC2)CC1)[C@@H](C)c1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4179566 | cell-based format |
| CHEMBL4216387 |  |
IC50 | = | 0.89 | nM | 589.78 | CCOc1ccc(CN(C)C)cc1NC(=O)[C@H](NC(=O)N1CCC(C(=O)CC(C)C)CC1)[C@@H](C)c1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4179566 | cell-based format |
| CHEMBL4203793 |  |
IC50 | = | 0.98 | nM | 588.75 | CC(=O)c1ccc(CN(C)C)cc1NC(=O)[C@H](NC(=O)N1CCN(C(=O)C(C)(C)C)CC1)[C@@H](C)c1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4179566 | cell-based format |
| CHEMBL4208009 |  |
IC50 | = | 1.1 | nM | 575.75 | CCOc1ccc(CN(C)C)cc1NC(=O)[C@H](NC(=O)N1CCC(C(=O)C(C)C)CC1)[C@@H](C)c1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4179566 | cell-based format |
| CHEMBL4203387 |  |
IC50 | = | 1.8 | nM | 586.74 | CC(=O)c1ccc(CN(C)C)cc1NC(=O)[C@H](NC(=O)N1CCN(C(=O)C2CCC2)CC1)[C@@H](C)c1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4179566 | cell-based format |
| CHEMBL4215052 |  |
IC50 | = | 2.0 | nM | 573.74 | CC(=O)c1ccc(CN(C)C)cc1NC(=O)[C@H](NC(=O)N1CCC(C(=O)C(C)C)CC1)[C@@H](C)c1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4179566 | cell-based format |
| CHEMBL4202861 |  |
IC50 | = | 2.1 | nM | 588.75 | CCOc1ccc(CN(C)C)cc1NC(=O)[C@H](NC(=O)N1CCN(C(=O)C2CCC2)CC1)[C@@H](C)c1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4179566 | cell-based format |
| CHEMBL4207735 |  |
IC50 | = | 2.3 | nM | 590.77 | CCOc1ccc(CN(C)C)cc1NC(=O)[C@H](NC(=O)N1CCN(C(=O)C(C)(C)C)CC1)[C@@H](C)c1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4179566 | cell-based format |
| CHEMBL4204193 |  |
IC50 | = | 2.3 | nM | 599.73 | CCOc1ccc(CN(C)C)cc1NC(=O)[C@H](NC(=O)N1CCC(C(=O)c2ccco2)CC1)[C@@H](C)c1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4179566 | cell-based format |
| CHEMBL227212 |  |
IC50 | = | 83.0 | nM | 551.69 | NCCCC[C@@H](C(=O)NCc1ccccc1)N1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)Cc2ccccc2)C1=O | Homo sapiens | CHEMBL888500 | single protein format |
| CHEMBL316559 |  |
IC50 | = | 85.0 | nM | 568.72 | CC(C)(C)OC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccc(-c2ccccc2)cc1 | Homo sapiens | CHEMBL801243 | cell-based format |
| CHEMBL93351 |  |
IC50 | = | 275.0 | nM | 554.76 | NCCCC1CCCN2C(=O)[C@@H](Cc3c[nH]c4ccccc34)SCCN(Cc3cccc4ccccc34)C(=O)C12 | Homo sapiens | CHEMBL801246 | single protein format |
| CHEMBL473160 |  |
IC50 | = | 290.0 | nM | 590.6 | COC(=O)[C@H](CCCCN)N1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)Cc2ccccc2)C1=O.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL1009179 | cell-based format |
| CHEMBL501699 |  |
IC50 | = | 292.0 | nM | 589.61 | CC(=O)N[C@@H]1Cc2c([nH]c3ccccc23)CN([C@@H](CCCCN)C(=O)NCc2ccccc2)C1=O.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL1009179 | cell-based format |
| CHEMBL227211 |  |
IC50 | = | 357.0 | nM | 508.67 | NCCCCCN1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)CC(c2ccccc2)c2ccccc2)C1=O | Homo sapiens | CHEMBL888500 | single protein format |
| CHEMBL1254476 |  |
IC50 | = | 650.0 | nM | 544.65 | COC[C@H]1O[C@@H](OCc2ccc3ccccc3c2)[C@H](NC(=O)CCN)[C@@H](OCc2ccc3ccccc3c2)[C@@H]1O | Homo sapiens | CHEMBL1252084 | cell-based format |
| CHEMBL1254967 |  |
IC50 | = | 980.0 | nM | 545.1 | CS[C@@H]1O[C@H](COCc2ccc(Cl)cc2)[C@@H](O)[C@@H](OCc2ccc3ccccc3c2)[C@H]1NC(=O)CCN | Homo sapiens | CHEMBL1252084 | cell-based format |
| CHEMBL1766103 |  |
Ki | = | 0.025 | nM | 432.95 | Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1 | Homo sapiens | CHEMBL1767825 | cell-based format |