P30872 | SSR1_HUMAN | Somatostatin receptor type 1 (SSTR1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 75~323 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL227212 |  |
IC50 | = | 233.0 | nM | 551.69 | NCCCC[C@@H](C(=O)NCc1ccccc1)N1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)Cc2ccccc2)C1=O | Homo sapiens | CHEMBL888499 | single protein format |
| CHEMBL501699 |  |
IC50 | = | 253.0 | nM | 589.61 | CC(=O)N[C@@H]1Cc2c([nH]c3ccccc23)CN([C@@H](CCCCN)C(=O)NCc2ccccc2)C1=O.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL1009178 | cell-based format |
| CHEMBL93351 |  |
IC50 | = | 407.0 | nM | 554.76 | NCCCC1CCCN2C(=O)[C@@H](Cc3c[nH]c4ccccc34)SCCN(Cc3cccc4ccccc34)C(=O)C12 | Homo sapiens | CHEMBL801244 | single protein format |
| CHEMBL92914 |  |
IC50 | = | 501.0 | nM | 514.7 | NCCCC[C@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)SCCN(Cc2cccc3ccccc23)C1=O | Homo sapiens | CHEMBL801244 | single protein format |
| CHEMBL473160 |  |
IC50 | = | 962.0 | nM | 590.6 | COC(=O)[C@H](CCCCN)N1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)Cc2ccccc2)C1=O.O=C(O)C(F)(F)F | Homo sapiens | CHEMBL1009178 | cell-based format |
| CHEMBL71723 |  |
Ki | = | 1.6 | nM | 539.72 | NC[C@@H]1CCC[C@H](CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)N2CCC3(C=Cc4ccccc43)CC2)C1 | Homo sapiens | CHEMBL807426 | cell-based format |
| CHEMBL363092 |  |
Ki | = | 58.0 | nM | 460.58 | NCCCCn1c(SCCc2c[nH]c3cc(F)ccc23)nnc1-c1ccc2ccccc2n1 | Homo sapiens | CHEMBL830344 | single protein format |
| CHEMBL5175637 |  |
Ki | = | 97.8 | nM | 471.52 | Fc1ccc2c(Cc3nnc(Cc4c[nH]c5cc(F)ccc45)n3CCCc3c[nH]cn3)c[nH]c2c1 | Homo sapiens | CHEMBL5137206 | cell membrane format |
| CHEMBL187768 |  |
Ki | = | 130.0 | nM | 456.62 | Cc1cccc2c(CCSc3nnc(-c4ccc5ccccc5n4)n3CCCCN)c[nH]c12 | Homo sapiens | CHEMBL830344 | single protein format |
| CHEMBL185861 |  |
Ki | = | 180.0 | nM | 477.04 | NCCCCn1c(SCCc2c[nH]c3c(Cl)cccc23)nnc1-c1ccc2ccccc2n1 | Homo sapiens | CHEMBL830344 | single protein format |
| CHEMBL5190457 |  |
Ki | = | 263.5 | nM | 493.38 | Fc1ccc2c(Cc3nnc(Cc4cccc(Br)c4)n3CCCc3c[nH]cn3)c[nH]c2c1 | Homo sapiens | CHEMBL5137206 | cell membrane format |
| CHEMBL5206148 |  |
Ki | = | 365.3 | nM | 494.52 | COc1ccc2[nH]cc(Cc3nnc(Cc4cccc(C(F)(F)F)c4)n3CCCc3c[nH]cn3)c2c1 | Homo sapiens | CHEMBL5137206 | cell membrane format |
| CHEMBL5172814 |  |
Ki | = | 443.2 | nM | 492.58 | CS(=O)(=O)c1cccc(Cc2nnc(Cc3c[nH]c4cc(F)ccc34)n2CCCc2c[nH]cn2)c1 | Homo sapiens | CHEMBL5137206 | cell membrane format |
| CHEMBL5177573 |  |
Ki | = | 468.0 | nM | 432.48 | Fc1ccc(Cc2nnc(Cc3c[nH]c4cc(F)ccc34)n2CCCc2c[nH]cn2)cc1 | Homo sapiens | CHEMBL5137206 | cell membrane format |
| CHEMBL434159 |  |
Ki | = | 530.0 | nM | 484.63 | Cc1cccc2c(C(=O)CCSc3nnc(-c4ccc5ccccc5n4)n3CCCCN)c[nH]c12 | Homo sapiens | CHEMBL830344 | single protein format |
| CHEMBL305279 |  |
Ki | = | 537.0 | nM | 539.72 | NCC1CCCC(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)N2CCC3(C=Cc4ccccc43)CC2)C1 | Homo sapiens | CHEMBL807426 | cell-based format |
| CHEMBL5193727 |  |
Ki | = | 543.6 | nM | 482.49 | Fc1ccc2c(Cc3nnc(Cc4cccc(C(F)(F)F)c4)n3CCCc3c[nH]cn3)c[nH]c2c1 | Homo sapiens | CHEMBL5137206 | cell membrane format |
| CHEMBL5177487 |  |
Ki | = | 587.6 | nM | 464.5 | FC(F)(F)c1cccc(Cc2nnc(Cc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)c1 | Homo sapiens | CHEMBL5137206 | cell membrane format |
| CHEMBL5180551 |  |
Ki | = | 624.4 | nM | 430.94 | Clc1ccc(Cc2nnc(Cc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)cc1 | Homo sapiens | CHEMBL5137206 | cell membrane format |
| CHEMBL3287613 |  |
Ki | = | 656.0 | nM | 365.45 | O=C(N[C@@H]1CCCC[C@@H]1NCc1c[nH]c2ccccc12)c1ccc(F)cc1 | Homo sapiens | CHEMBL3296536 | cell membrane format |