P30559 | OXYR_HUMAN | Oxytocin receptor (OXTR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 56~329 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL154668 |  |
IC50 | = | 4.62 | nM | 554.78 | Cc1ccccc1N1CCN(S(=O)(=O)CC23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1 | Homo sapiens | CHEMBL4726271 | cell-based format |
| CHEMBL4594444 |  |
IC50 | = | 15.5 | nM | 543.33 | C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 | Homo sapiens | CHEMBL5464409 | single protein format |
| CHEMBL363910 |  |
IC50 | = | 353.0 | nM | 402.89 | Cc1ccn(-c2ccc(C(=O)N3Cc4cccn4Cc4ccccc43)c(Cl)c2)n1 | Homo sapiens | CHEMBL898900 | cell-based format |
| CHEMBL49429 |  |
IC50 | = | 519.0 | nM | 473.94 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)c(Cl)c1 | Homo sapiens | CHEMBL898900 | cell-based format |
| CHEMBL238206 |  |
IC50 | = | 1000.0 | nM | 505.93 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2Cn2cccc2C(=O)O)c(Cl)c1 | Homo sapiens | CHEMBL898900 | cell-based format |
| CHEMBL237987 |  |
IC50 | = | 1000.0 | nM | 426.83 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2C(=O)O)c(Cl)c1 | Homo sapiens | CHEMBL898900 | cell-based format |
| CHEMBL237772 |  |
IC50 | = | 1000.0 | nM | 489.93 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CC3C=CC(=O)N3Cc3ccccc32)c(Cl)c1 | Homo sapiens | CHEMBL898900 | cell-based format |
| CHEMBL392363 |  |
IC50 | = | 1000.0 | nM | 489.93 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2C=C3CCC(=O)N3Cc3ccccc32)c(Cl)c1 | Homo sapiens | CHEMBL898900 | cell-based format |
| CHEMBL429736 |  |
Ki | = | 0.65 | nM | 494.59 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(C)n1 | Homo sapiens | CHEMBL946012 | single protein format |
| CHEMBL25353 |  |
Ki | = | 0.86 | nM | 533.55 | O=C(Cc1ccc(N2CCOCC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | Homo sapiens | CHEMBL761401 | single protein format |
| CHEMBL2113181 |  |
Ki | = | 0.9 | nM | 598.08 | O=C(CCc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1)NCCCO | Homo sapiens | CHEMBL863355 | cell-based format |
| CHEMBL2113185 |  |
Ki | = | 0.9 | nM | 598.08 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | Homo sapiens | CHEMBL863355 | cell-based format |
| CHEMBL2113201 |  |
Ki | = | 1.1 | nM | 570.07 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL863355 | cell-based format |
| CHEMBL278818 |  |
Ki | = | 1.4 | nM | 577.6 | O=C(Cc1ccc(OCCN2CCOCC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | Homo sapiens | CHEMBL761401 | single protein format |
| CHEMBL24526 |  |
Ki | = | 1.4 | nM | 589.61 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(OCC(F)(F)F)c2)CC1 | Homo sapiens | CHEMBL761401 | single protein format |
| CHEMBL2113189 |  |
Ki | = | 1.6 | nM | 598.08 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)NC(=O)c3ccccc32)c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL863355 | cell-based format |
| CHEMBL104237 |  |
Ki | = | 2.0 | nM | 505.55 | COc1cc(O[C@H](C)c2ccncc2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | Homo sapiens | CHEMBL761405 | cell-based format |
| CHEMBL2113203 |  |
Ki | = | 2.1 | nM | 556.04 | CN(C)CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL863355 | cell-based format |
| CHEMBL24682 |  |
Ki | = | 2.4 | nM | 575.58 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(OC(F)(F)F)c2)CC1 | Homo sapiens | CHEMBL761401 | single protein format |
| CHEMBL2113208 |  |
Ki | = | 3.0 | nM | 587.05 | COCCOCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL863355 | cell-based format |