P30550 | GRPR_HUMAN | Gastrin-releasing peptide receptor (GRPR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 57~320 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL405908 |  |
IC50 | = | 16.0 | nM | 584.68 | COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)nc1 | Homo sapiens | CHEMBL883283 | tissue-based format |
| CHEMBL312926 |  |
Ki | = | 3.7 | nM | 583.69 | COc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL85291 |  |
Ki | = | 5.8 | nM | 597.72 | CCOc1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL327388 |  |
Ki | = | 6.4 | nM | 598.66 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccc([N+](=O)[O-])cc2)CCCCC1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL433143 |  |
Ki | = | 9.0 | nM | 596.73 | CN(C)c1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL329650 |  |
Ki | = | 17.0 | nM | 554.65 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccccn2)CCCCC1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL87846 |  |
Ki | = | 32.0 | nM | 569.66 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccc(O)cc2)CCCCC1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL313030 |  |
Ki | = | 35.0 | nM | 595.74 | CC(C)c1ccc(C2(CNC(=O)[C@](C)(Cc3c[nH]c4ccccc34)NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCCCC2)cc1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL327840 |  |
Ki | = | 37.0 | nM | 534.66 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(C#N)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL327678 |  |
Ki | = | 85.0 | nM | 578.54 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)c(Cl)c1)C(=O)NCC1(c2ccccn2)CCCCC1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL313346 |  |
Ki | = | 85.0 | nM | 554.65 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1cccc([N+](=O)[O-])c1)C(=O)NCC1(c2ccccn2)CCCCC1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL86370 |  |
Ki | = | 89.0 | nM | 553.66 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc([N+](=O)[O-])cc1)C(=O)NCC1(c2ccccc2)CCCCC1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL90614 |  |
Ki | = | 124.0 | nM | 577.65 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL316085 |  |
Ki | = | 149.0 | nM | 544.1 | C[C@@](Cc1c[nH]c2ccccc12)(NC(=O)Nc1ccc(Cl)cc1)C(=O)NCC1(c2ccccn2)CCCCC1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL88010 |  |
Ki | = | 273.0 | nM | 551.74 | CC(C)c1ccc(NC(=O)N[C@@](C)(Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 | Homo sapiens | CHEMBL650353 | single protein format |
| CHEMBL89734 |  |
Ki | = | 404.0 | nM | 583.69 | COc1ccccc1C1(CNC(=O)[C@](C)(Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc([N+](=O)[O-])cc2)CCCCC1 | Homo sapiens | CHEMBL650353 | single protein format |