P30536 | TSPO_HUMAN | Translocator protein (TSPO)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03073 | TspO_MBR - TspO/MBR family | 12~156 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL63064 |  |
IC50 | = | 0.28 | nM | 395.43 | COc1ccc(OC)c(CN(C(C)=O)c2cc(F)ccc2Oc2ccccc2)c1 | Homo sapiens | CHEMBL5104235 | single protein format |
| CHEMBL205767 |  |
IC50 | = | 0.92 | nM | 409.91 | CC(=O)N(Cc1ccccc1OC(C)C)c1ccc(Cl)cc1Oc1ccccc1 | Homo sapiens | CHEMBL3878758 | single protein format |
| CHEMBL3970955 |  |
IC50 | = | 1.6 | nM | 395.43 | COc1ccc(OC)c(CN(C(C)=O)c2ccc(F)cc2Oc2ccccc2)c1 | Homo sapiens | CHEMBL3878758 | single protein format |
| CHEMBL481537 |  |
IC50 | = | 2.5 | nM | 352.87 | CCC(C)N(C)C(=O)c1cc2ccccc2c(-c2ccccc2Cl)n1 | Homo sapiens | CHEMBL953129 | single protein format |
| CHEMBL5179737 |  |
IC50 | = | 6.7 | nM | 241.29 | CC(=O)N(C)c1ccccc1Oc1ccccc1 | Homo sapiens | CHEMBL5104235 | single protein format |
| CHEMBL54349 |  |
IC50 | = | 7.9 | nM | 404.34 | CCCN(CCC)C(=O)Cc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12 | Homo sapiens | CHEMBL4415150 | single protein format |
| CHEMBL253597 |  |
IC50 | = | 8.07 | nM | 347.4 | CC(=O)N(Cc1ccccc1O[11CH3])c1cnccc1Oc1ccccc1 | Homo sapiens | CHEMBL5104238 | cell-based format |
| CHEMBL5199978 |  |
IC50 | = | 8.28 | nM | 365.39 | CC(=O)N(Cc1ccccc1OC[18F])c1cnccc1Oc1ccccc1 | Homo sapiens | CHEMBL5104238 | cell-based format |
| CHEMBL106237 |  |
IC50 | = | 11.8 | nM | 380.45 | CCCN(CCC)C(=O)Cc1c(-c2ccccc2)nc2ccc([N+](=O)[O-])cn12 | Homo sapiens | CHEMBL4415150 | single protein format |
| CHEMBL3265238 |  |
IC50 | = | 350.0 | nM | 507.2 | COc1cccc(NC[C@H](F)Cn2c3ccc(Br)cc3c3cc(Br)ccc32)n1 | Homo sapiens | CHEMBL3266314 | single protein format |
| CHEMBL3769755 |  |
IC50 | = | 400.0 | nM | 414.92 | COC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21 | Homo sapiens | CHEMBL4199266 | single protein format |
| CHEMBL1672418 |  |
IC50 | = | 620.0 | nM | 444.32 | CCC(C)N(C)C(=O)c1cc2ccccc2c(-c2ccccc2I)n1 | Homo sapiens | CHEMBL1679493 | single protein format |
| CHEMBL3265237 |  |
IC50 | = | 680.0 | nM | 507.2 | COc1cccc(NC[C@@H](F)Cn2c3ccc(Br)cc3c3cc(Br)ccc32)n1 | Homo sapiens | CHEMBL3266314 | single protein format |
| CHEMBL3987016 |  |
IC50 | = | 800.0 | nM | 459.47 | CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 | Homo sapiens | CHEMBL4020290 | single protein format |
| CHEMBL520465 |  |
Ki | = | 0.15 | nM | 449.34 | CCCN(CCC)C(=O)Cc1c(-c2ccc([N+](=O)[O-])cc2)nc2c(Cl)cc(Cl)cn12 | Homo sapiens | CHEMBL4415150 | single protein format |
| CHEMBL63064 | |
Ki | = | 0.188 | nM | 395.43 | COc1ccc(OC)c(CN(C(C)=O)c2cc(F)ccc2Oc2ccccc2)c1 | Homo sapiens | CHEMBL648648 | assay format |
| CHEMBL401000 |  |
Ki | = | 0.242 | nM | 394.43 | COc1ccc(O[11CH3])c(CN(C(C)=O)c2cc(F)ccc2Oc2ccccc2)c1 | Homo sapiens | CHEMBL924983 | single protein format |
| CHEMBL5428961 |  |
Ki | = | 0.27 | nM | 465.39 | CCCN(CCC)C(=O)Cc1c(-c2ccc(OCC[18F])cc2)nc2c(Cl)cc(Cl)cn12 | Homo sapiens | CHEMBL5345579 | single protein format |
| CHEMBL2088374 |  |
Ki | = | 0.28 | nM | 388.42 | COc1ccc(-c2ccc3oc(=O)n(CC(=O)N(C)c4ccccc4)c3c2)cc1 | Homo sapiens | CHEMBL5104236 | single protein format |
| CHEMBL5275028 |  |
Ki | = | 0.3 | nM | 393.44 | COc1ccc(OC)c(CC(C(=O)C[18F])c2ccccc2Oc2ccccc2)c1 | Homo sapiens | CHEMBL5228264 | single protein format |