P30419 | NMT1_HUMAN | Glycylpeptide N-tetradecanoyltransferase 1 (NMT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01233 | NMT - Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain | 141~294 | |
| PF02799 | NMT_C - Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain | 308~494 |
3D structures mapped by conservation among orthologs
[ Domain: "Acyl-CoA N-acyltransferases (Nat)" // NMT ]
[ Domain: "Acyl-CoA N-acyltransferases (Nat)" // NMT_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4445137 |  |
IC50 | < | 1.0 | nM | 453.54 | Cc1nn(C)c(C)c1CCOc1c(-c2ccc3c(c2)c(CN(C)C)nn3C)ccc(F)c1F | Homo sapiens | CHEMBL4381020 | single protein format |
| CHEMBL4115136 |  |
IC50 | = | 2.0 | nM | 466.65 | Cc1c(NS(=O)(=O)c2ccc(-c3ccc4c(c3)CN(C)CCC4)cc2)c(CC(C)C)nn1C | Homo sapiens | CHEMBL3887334 | single protein format |
| CHEMBL3980411 |  |
IC50 | = | 3.0 | nM | 523.49 | CCN(c1c(C)nn(C)c1C)S(=O)(=O)c1c(Cl)cc(-c2ccnc(N3CCNCC3)c2)cc1Cl | Homo sapiens | CHEMBL3887334 | single protein format |
| CHEMBL1230468 |  |
IC50 | = | 3.0 | nM | 495.44 | Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(-c2ccnc(N3CCNCC3)c2)cc1Cl | Homo sapiens | CHEMBL1954201 | single protein format |
| CHEMBL4111551 |  |
IC50 | = | 3.0 | nM | 460.99 | Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(-c2ccnc(N3CCNCC3)c2)cc1Cl | Homo sapiens | CHEMBL3887334 | single protein format |
| CHEMBL3920615 |  |
IC50 | = | 4.0 | nM | 473.47 | Cc1nn(C)c(C)c1N(C)S(=O)(=O)c1c(Cl)cc(CCCC2CCNCC2)cc1Cl | Homo sapiens | CHEMBL3887334 | single protein format |
| CHEMBL3358119 |  |
IC50 | = | 4.0 | nM | 523.48 | Cc1nn(C)c(C)c1N(C(F)F)S(=O)(=O)c1c(Cl)cc(CCCCC2CCNCC2)cc1Cl | Homo sapiens | CHEMBL3387685 | single protein format |
| CHEMBL3357702 |  |
IC50 | = | 4.0 | nM | 509.46 | Cc1nn(C)c(C)c1N(C)S(=O)(=O)c1c(Cl)cc(-c2ccnc(N3CCNCC3)c2)cc1Cl | Homo sapiens | CHEMBL3387685 | single protein format |
| CHEMBL3357697 |  |
IC50 | = | 4.0 | nM | 487.5 | Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(CCCCC2CCN(C)CC2)cc1Cl | Homo sapiens | CHEMBL3387685 | single protein format |
| CHEMBL3357685 |  |
IC50 | = | 4.0 | nM | 537.52 | Cc1c(NS(=O)(=O)c2c(Cl)cc(-c3ccnc(N4CCNCC4)c3)cc2Cl)c(CC(C)C)nn1C | Homo sapiens | CHEMBL3387685 | single protein format |
| CHEMBL4110040 |  |
IC50 | = | 4.0 | nM | 452.62 | Cc1c(NS(=O)(=O)c2ccc(-c3ccc4c(c3)CNCCC4)cc2)c(CC(C)C)nn1C | Homo sapiens | CHEMBL3887334 | single protein format |
| CHEMBL3357699 |  |
IC50 | = | 5.0 | nM | 473.47 | Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(CCCCC2CCNCC2)cc1Cl | Homo sapiens | CHEMBL3387685 | single protein format |
| CHEMBL4106967 |  |
IC50 | = | 5.0 | nM | 452.62 | Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(-c2cccc(CC3CCN(C)CC3)c2)cc1 | Homo sapiens | CHEMBL3887334 | single protein format |
| CHEMBL3911634 |  |
IC50 | = | 5.0 | nM | 536.53 | Cc1nn(C)c(C)c1N(C)S(=O)(=O)c1c(Cl)cc(-c2cccc(CN3CCN(C)CC3)c2)cc1Cl | Homo sapiens | CHEMBL3887334 | single protein format |
| CHEMBL3358120 |  |
IC50 | = | 5.0 | nM | 537.5 | Cc1nn(C)c(C)c1N(C(F)F)S(=O)(=O)c1c(Cl)cc(CCCCC2CCN(C)CC2)cc1Cl | Homo sapiens | CHEMBL3387685 | single protein format |
| CHEMBL3358121 |  |
IC50 | = | 5.0 | nM | 539.48 | Cc1nn(C)c(C)c1N(C(F)F)S(=O)(=O)c1c(Cl)cc(CCCOC2CCN(C)CC2)cc1Cl | Homo sapiens | CHEMBL3387685 | single protein format |
| CHEMBL4109103 |  |
IC50 | = | 6.0 | nM | 440.57 | Cc1cc(-c2ccnc(N3CCNCC3)c2)ccc1S(=O)(=O)Nc1c(C)nn(C)c1C | Homo sapiens | CHEMBL3887334 | single protein format |
| CHEMBL4113504 |  |
IC50 | = | 6.0 | nM | 517.7 | Cc1c(NS(=O)(=O)c2ccc(-c3cccc(CNCCc4cccnc4)c3)cc2)c(CC(C)C)nn1C | Homo sapiens | CHEMBL3887334 | single protein format |
| CHEMBL3894086 |  |
IC50 | = | 7.0 | nM | 538.49 | Cc1nn(C)c(C)c1N(C(F)F)S(=O)(=O)c1c(Cl)cc(CCCN2CCCN(C)CC2)cc1Cl | Homo sapiens | CHEMBL3887334 | single protein format |
| CHEMBL4112331 |  |
IC50 | = | 7.0 | nM | 426.55 | Cc1nn(C)c(C)c1NS(=O)(=O)c1ccc(-c2ccnc(N3CCNCC3)c2)cc1 | Homo sapiens | CHEMBL3887334 | single protein format |