P30411 | BKRB2_HUMAN | B2 bradykinin receptor (BDKRB2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 74~332 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL439737 |  |
IC50 | = | 1.1 | nM | 591.5 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cc1 | Homo sapiens | CHEMBL653424 | cell-based format |
| CHEMBL130517 |  |
IC50 | = | 1.4 | nM | 592.48 | CC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ccc(C)nc34)c2Cl)cn1 | Homo sapiens | CHEMBL653418 | cell-based format |
| CHEMBL140383 |  |
IC50 | = | 2.6 | nM | 569.71 | CNC(=O)c1ccc(/C=C/C(=O)NCc2ccccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | Homo sapiens | CHEMBL884128 | cell-based format |
| CHEMBL559436 |  |
IC50 | = | 4.0 | nM | 539.95 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | Homo sapiens | CHEMBL1026061 | cell-based format |
| CHEMBL543781 |  |
IC50 | = | 4.8 | nM | 587.12 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1.Cl | Homo sapiens | CHEMBL653418 | cell-based format |
| CHEMBL143697 |  |
IC50 | = | 4.8 | nM | 550.66 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | Homo sapiens | CHEMBL884128 | cell-based format |
| CHEMBL561634 |  |
IC50 | = | 5.1 | nM | 471.95 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3Cn3ccccc3=O)c2n1 | Homo sapiens | CHEMBL1026061 | cell-based format |
| CHEMBL559506 |  |
IC50 | = | 5.4 | nM | 443.55 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3CNC(=O)C(C)C)c2n1 | Homo sapiens | CHEMBL1026061 | cell-based format |
| CHEMBL130775 |  |
IC50 | = | 5.8 | nM | 575.73 | CNC(=O)c1ccc(/C=C/C(=O)NCc2sccc2-c2ccc(C)c(COc3cccc4ccc(C)nc34)c2C)cc1 | Homo sapiens | CHEMBL884128 | cell-based format |
| CHEMBL562296 |  |
IC50 | = | 6.0 | nM | 434.88 | CC(=O)OCc1cncc(Cl)c1C(=O)c1cccc2c(-c3ccnn3C)cc(C)nc12 | Homo sapiens | CHEMBL1026061 | cell-based format |
| CHEMBL558279 |  |
IC50 | = | 6.5 | nM | 465.94 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3OCC(=O)N(C)C)c2n1 | Homo sapiens | CHEMBL1026061 | cell-based format |
| CHEMBL563878 |  |
IC50 | = | 6.6 | nM | 464.96 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNC(=O)N(C)C)c2n1 | Homo sapiens | CHEMBL1026061 | cell-based format |
| CHEMBL44087 |  |
IC50 | = | 7.2 | nM | 569.66 | CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(C)c(COc3cccc4c3nc(OC)n4C)c2C)cc1 | Homo sapiens | CHEMBL653418 | cell-based format |
| CHEMBL564841 |  |
IC50 | = | 7.5 | nM | 482.01 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3SCC(=O)N(C)C)c2n1 | Homo sapiens | CHEMBL1026061 | cell-based format |
| CHEMBL550827 |  |
IC50 | = | 7.8 | nM | 463.97 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3CNC(=O)C(C)C)c2n1 | Homo sapiens | CHEMBL1026061 | cell-based format |
| CHEMBL552090 |  |
IC50 | = | 8.3 | nM | 465.94 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(Cl)cncc3COC(=O)N(C)C)c2n1 | Homo sapiens | CHEMBL1026061 | cell-based format |
| CHEMBL132860 |  |
IC50 | = | 8.5 | nM | 570.65 | COc1nc2c(OCc3c(C)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(NC(C)=O)nc4)c3C)cccc2n1C | Homo sapiens | CHEMBL653418 | cell-based format |
| CHEMBL563956 |  |
IC50 | = | 8.7 | nM | 519.53 | Cc1cc(-c2[nH]ncc2C)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | Homo sapiens | CHEMBL1026061 | cell-based format |
| CHEMBL559825 |  |
IC50 | = | 8.8 | nM | 519.53 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3Cn3cccc(C(F)(F)F)c3=O)c2n1 | Homo sapiens | CHEMBL1026061 | cell-based format |
| CHEMBL559565 |  |
IC50 | = | 10.0 | nM | 483.62 | Cc1cc(-c2ccnn2C)c2cccc(OCc3c(C)ccnc3CNC(=O)C3CCCCC3)c2n1 | Homo sapiens | CHEMBL1026061 | cell-based format |