P30307 | MPIP3_HUMAN | M-phase inducer phosphatase 3 (CDC25C)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00581 | Rhodanese - Rhodanese-like domain | 323~419 | |
| PF06617 | M-inducer_phosp - M-phase inducer phosphatase | 200~247 |
3D structures mapped by conservation among orthologs
[ Domain: "Rhodanese/Cell cycle control phosphatase" // Rhodanese ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5288122 |  |
IC50 | = | 23.0 | nM | 265.34 | Cc1nc2c(s1)C(=O)C=C(NCCN(C)C)C2=O | Homo sapiens | CHEMBL5245826 | single protein format |
| CHEMBL5271462 |  |
IC50 | = | 23.0 | nM | 347.32 | CN(C)CCNC1=CC(=O)c2nc(-c3cc(F)ccc3F)oc2C1=O | Homo sapiens | CHEMBL5245826 | single protein format |
| CHEMBL429095 |  |
IC50 | = | 56.9 | nM | 310.4 | O=C1C(SCCO)=C(SCCO)C(=O)c2ccccc21 | Homo sapiens | CHEMBL1767949 | single protein format |
| CHEMBL5423941 |  |
IC50 | = | 60.0 | nM | 409.83 | CC(NC1=C(Cl)C(=O)c2cccnc2C1=O)c1cn(-c2ccc(CO)cc2)nn1 | Homo sapiens | CHEMBL5363091 | single protein format |
| CHEMBL4521092 |  |
IC50 | = | 90.0 | nM | 393.83 | Cc1ccc(Cn2cc(CNC3=C(Cl)C(=O)c4cccnc4C3=O)nn2)cc1 | Homo sapiens | CHEMBL4313752 | single protein format |
| CHEMBL4093222 |  |
IC50 | = | 100.0 | nM | 326.31 | O=C1C=CC(=O)c2c1ccc1c2c(=O)oc2c3ccccc3ccc12 | Homo sapiens | CHEMBL4034742 | assay format |
| CHEMBL199359 |  |
IC50 | = | 130.0 | nM | 263.3 | CCc1nc2c(o1)C(O)=C/C(=N\CCN(C)C)C2=O | Homo sapiens | CHEMBL858783 | single protein format |
| CHEMBL382593 |  |
IC50 | = | 130.0 | nM | 263.3 | CCc1nc2c(o1)C(=O)C(NCCN(C)C)=CC2=O | Homo sapiens | CHEMBL858783 | single protein format |
| CHEMBL373195 |  |
IC50 | = | 150.0 | nM | 265.34 | Cc1nc2c(s1)C(O)=C/C(=N\CCN(C)C)C2=O | Homo sapiens | CHEMBL858783 | single protein format |
| CHEMBL1765351 |  |
IC50 | = | 170.0 | nM | 279.37 | CC1=C(NCCN(C)C)C(=O)c2nc(C)sc2C1=O | Homo sapiens | CHEMBL1767949 | single protein format |
| CHEMBL4566962 |  |
IC50 | = | 210.0 | nM | 404.82 | N#Cc1cccc(Cn2cc(CNC3=C(Cl)C(=O)c4cccnc4C3=O)nn2)c1 | Homo sapiens | CHEMBL4313752 | single protein format |
| CHEMBL199360 |  |
IC50 | = | 230.0 | nM | 311.34 | CN(C)CC/N=C1\C=C(O)c2oc(-c3ccccc3)nc2C1=O | Homo sapiens | CHEMBL858783 | single protein format |
| CHEMBL200805 |  |
IC50 | = | 230.0 | nM | 311.34 | CN(C)CC/N=C1\C=C(O)c2nc(-c3ccccc3)oc2C1=O | Homo sapiens | CHEMBL858783 | single protein format |
| CHEMBL337173 |  |
IC50 | = | 250.0 | nM | 321.76 | O=C1C(Cl)=C(NCCN2CCOCC2)C(=O)c2ncccc21 | Homo sapiens | CHEMBL858783 | single protein format |
| CHEMBL4066424 |  |
IC50 | = | 300.0 | nM | 347.37 | CCN(CC)c1ccc2c(c1)oc(=O)c1c3c(ccc12)C(=O)C=CC3=O | Homo sapiens | CHEMBL4034742 | assay format |
| CHEMBL4085485 |  |
IC50 | = | 400.0 | nM | 294.24 | O=C1C=CC(=O)c2c1ccc1c2c(=O)oc2ccc(F)cc21 | Homo sapiens | CHEMBL4034742 | assay format |
| CHEMBL4466461 |  |
IC50 | = | 420.0 | nM | 404.82 | N#Cc1ccccc1Cn1cc(CNC2=C(Cl)C(=O)c3cccnc3C2=O)nn1 | Homo sapiens | CHEMBL4313752 | single protein format |
| CHEMBL4060132 |  |
IC50 | = | 690.0 | nM | 294.24 | O=C1C=CC(=O)c2c1ccc1c2c(=O)oc2cc(F)ccc21 | Homo sapiens | CHEMBL4034742 | assay format |
| CHEMBL4097725 |  |
IC50 | = | 770.0 | nM | 310.69 | O=C1C=CC(=O)c2c1ccc1c2c(=O)oc2cc(Cl)ccc21 | Homo sapiens | CHEMBL4034742 | assay format |
| CHEMBL4086414 |  |
IC50 | = | 800.0 | nM | 292.25 | O=C1C=CC(=O)c2c1ccc1c2c(=O)oc2cc(O)ccc21 | Homo sapiens | CHEMBL4034742 | assay format |