P30305 | MPIP2_HUMAN | M-phase inducer phosphatase 2 (CDC25B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00581 | Rhodanese - Rhodanese-like domain | 434~529 | |
| PF06617 | M-inducer_phosp - M-phase inducer phosphatase | 113~383 |
3D structures mapped by conservation among orthologs
[ Domain: "Rhodanese/Cell cycle control phosphatase" // Rhodanese ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5288122 |  |
IC50 | = | 53.0 | nM | 265.34 | Cc1nc2c(s1)C(=O)C=C(NCCN(C)C)C2=O | Homo sapiens | CHEMBL5245825 | single protein format |
| CHEMBL5271462 |  |
IC50 | = | 53.0 | nM | 347.32 | CN(C)CCNC1=CC(=O)c2nc(-c3cc(F)ccc3F)oc2C1=O | Homo sapiens | CHEMBL5245825 | single protein format |
| CHEMBL476648 |  |
IC50 | = | 80.0 | nM | 423.45 | C[C@@]12CCCc3coc(c31)C(=O)c1cc3c(cc12)C(=O)C1=C(NCCS1(=O)=O)C3=O | Homo sapiens | CHEMBL965758 | assay format |
| CHEMBL1481974 |  |
IC50 | = | 100.0 | nM | 316.27 | O=C(O)CCc1c2ccc(=O)c(O)c-2oc2c(O)c(O)ccc12 | Homo sapiens | CHEMBL2061093 | assay format |
| CHEMBL429095 |  |
IC50 | = | 100.0 | nM | 310.4 | O=C1C(SCCO)=C(SCCO)C(=O)c2ccccc21 | Homo sapiens | CHEMBL887183 | single protein format |
| CHEMBL1095726 |  |
IC50 | = | 120.0 | nM | 503.71 | CCCCCCCCCCCCCCCCCC(=O)c1cc(C(=O)Nc2ccsc2C(=O)O)[nH]n1 | Homo sapiens | CHEMBL1106602 | single protein format |
| CHEMBL200117 |  |
IC50 | = | 120.0 | nM | 569.74 | CCCCCCCCCCCCCCc1ccc(C(=O)c2ccc3c(-c4ccc(OCC(=O)O)cc4)nocc2-3)cc1 | Homo sapiens | CHEMBL865885 | single protein format |
| CHEMBL1097720 |  |
IC50 | = | 160.0 | nM | 497.68 | CCCCCCCCCCCCCCCCCC(=O)c1cc(C(=O)Nc2ccccc2C(=O)O)[nH]n1 | Homo sapiens | CHEMBL1106602 | single protein format |
| CHEMBL1098494 |  |
IC50 | = | 170.0 | nM | 514.11 | CCCCCCCCCCCCCCCCCC(=O)c1n[nH]c2c1C(=O)N(c1ccc(Cl)cc1)C2=O | Homo sapiens | CHEMBL1106602 | single protein format |
| CHEMBL5423941 |  |
IC50 | = | 190.0 | nM | 409.83 | CC(NC1=C(Cl)C(=O)c2cccnc2C1=O)c1cn(-c2ccc(CO)cc2)nn1 | Homo sapiens | CHEMBL5363090 | single protein format |
| CHEMBL557129 |  |
IC50 | = | 200.0 | nM | 439.5 | N#Cc1c(NS(=O)(=O)c2ccccc2)n(Cc2ccccc2)c2nc3ccccc3nc12 | Homo sapiens | CHEMBL1061731 | single protein format |
| CHEMBL337173 |  |
IC50 | = | 210.0 | nM | 321.76 | O=C1C(Cl)=C(NCCN2CCOCC2)C(=O)c2ncccc21 | Homo sapiens | CHEMBL662067 | single protein format |
| CHEMBL557673 |  |
IC50 | = | 210.0 | nM | 414.49 | O=S(=O)(Nc1cc2nc3ccccc3nc2n1Cc1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL1061731 | single protein format |
| CHEMBL1099219 |  |
IC50 | = | 230.0 | nM | 479.67 | CCCCCCCCCCCCCCCCCC(=O)c1n[nH]c2c1C(=O)N(c1ccccc1)C2=O | Homo sapiens | CHEMBL1106602 | single protein format |
| CHEMBL1097552 |  |
IC50 | = | 240.0 | nM | 514.11 | CCCCCCCCCCCCCCCCCC(=O)c1n[nH]c2c1C(=O)N(c1cccc(Cl)c1)C2=O | Homo sapiens | CHEMBL1106602 | single protein format |
| CHEMBL4452484 |  |
IC50 | = | 250.0 | nM | 250.34 | CSC1=C(SC)C(=O)c2ccccc2C1=O | Homo sapiens | CHEMBL4314170 | single protein format |
| CHEMBL1765351 |  |
IC50 | = | 250.0 | nM | 279.37 | CC1=C(NCCN(C)C)C(=O)c2nc(C)sc2C1=O | Homo sapiens | CHEMBL1767948 | single protein format |
| CHEMBL1098495 |  |
IC50 | = | 250.0 | nM | 558.56 | CCCCCCCCCCCCCCCCCC(=O)c1n[nH]c2c1C(=O)N(c1ccccc1Br)C2=O | Homo sapiens | CHEMBL1106602 | single protein format |
| CHEMBL50620 |  |
IC50 | = | 270.0 | nM | 202.21 | CCOC1=CC(=O)C(=O)c2ccccc21 | Homo sapiens | CHEMBL965759 | assay format |
| CHEMBL131199 |  |
IC50 | = | 300.0 | nM | 324.77 | O=C1C(Cl)=C(NC2CCc3ccccc32)C(=O)c2ncccc21 | Homo sapiens | CHEMBL662067 | single protein format |