P30304 | MPIP1_HUMAN | M-phase inducer phosphatase 1 (CDC25A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00581 | Rhodanese - Rhodanese-like domain | 377~473 | |
| PF06617 | M-inducer_phosp - M-phase inducer phosphatase | 87~327 |
3D structures mapped by conservation among orthologs
[ Domain: "Rhodanese/Cell cycle control phosphatase" // Rhodanese ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL429095 |  |
IC50 | = | 22.0 | nM | 310.4 | O=C1C(SCCO)=C(SCCO)C(=O)c2ccccc21 | Homo sapiens | CHEMBL1767947 | single protein format |
| CHEMBL5271462 |  |
IC50 | = | 23.0 | nM | 347.32 | CN(C)CCNC1=CC(=O)c2nc(-c3cc(F)ccc3F)oc2C1=O | Homo sapiens | CHEMBL5245824 | single protein format |
| CHEMBL5288122 |  |
IC50 | = | 23.0 | nM | 265.34 | Cc1nc2c(s1)C(=O)C=C(NCCN(C)C)C2=O | Homo sapiens | CHEMBL5245824 | single protein format |
| CHEMBL189010 |  |
IC50 | = | 50.0 | nM | 248.26 | O=C(O)CSC1=CC(=O)c2ccccc2C1=O | Homo sapiens | CHEMBL4314168 | single protein format |
| CHEMBL5423941 |  |
IC50 | = | 150.0 | nM | 409.83 | CC(NC1=C(Cl)C(=O)c2cccnc2C1=O)c1cn(-c2ccc(CO)cc2)nn1 | Homo sapiens | CHEMBL5363089 | single protein format |
| CHEMBL9470 |  |
IC50 | = | 220.0 | nM | 288.3 | CC(C)=CC[C@@H](O)C1=CC(=O)c2c(O)ccc(O)c2C1=O | Homo sapiens | CHEMBL4314168 | single protein format |
| CHEMBL1765351 |  |
IC50 | = | 250.0 | nM | 279.37 | CC1=C(NCCN(C)C)C(=O)c2nc(C)sc2C1=O | Homo sapiens | CHEMBL1767947 | single protein format |
| CHEMBL1481974 |  |
IC50 | = | 330.0 | nM | 316.27 | O=C(O)CCc1c2ccc(=O)c(O)c-2oc2c(O)c(O)ccc12 | Homo sapiens | CHEMBL2061097 | assay format |
| CHEMBL109990 |  |
IC50 | = | 440.0 | nM | 406.61 | CC(C)CCC[C@@H](C)[C@H]1CCC2[C@](C)(C[C@H](O)C3=CC(=O)OC3O)CCC[C@@]21C | Homo sapiens | CHEMBL662884 | single protein format |
| CHEMBL1765356 |  |
IC50 | = | 440.0 | nM | 406.61 | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@](C)(C[C@H](O)C3=CC(=O)OC3O)CCC[C@]12C | Homo sapiens | CHEMBL1767947 | single protein format |
| CHEMBL111717 |  |
IC50 | = | 480.0 | nM | 406.61 | CC(C)CCC[C@@H](C)[C@H]1CCC2[C@@](C)(C[C@@H](O)C3=CC(=O)OC3O)CCC[C@@]21C | Homo sapiens | CHEMBL662884 | single protein format |
| CHEMBL4521092 |  |
IC50 | = | 530.0 | nM | 393.83 | Cc1ccc(Cn2cc(CNC3=C(Cl)C(=O)c4cccnc4C3=O)nn2)cc1 | Homo sapiens | CHEMBL4313754 | single protein format |
| CHEMBL4566962 |  |
IC50 | = | 540.0 | nM | 404.82 | N#Cc1cccc(Cn2cc(CNC3=C(Cl)C(=O)c4cccnc4C3=O)nn2)c1 | Homo sapiens | CHEMBL4313754 | single protein format |
| CHEMBL1967787 |  |
IC50 | = | 650.0 | nM | 338.36 | O=C(O)C1CCCCC1c1c2ccc(=O)cc-2oc2cc(O)ccc12 | Homo sapiens | CHEMBL5245818 | single protein format |
| CHEMBL295316 |  |
IC50 | = | 700.0 | nM | 188.18 | CC1=CC(=O)c2c(O)cccc2C1=O | Homo sapiens | CHEMBL4314168 | single protein format |
| CHEMBL354794 |  |
IC50 | = | 700.0 | nM | 446.72 | CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](OCC(=O)O)CC[C@]4(C)[C@H]3CC[C@]12C | Homo sapiens | CHEMBL662888 | single protein format |
| CHEMBL182645 |  |
IC50 | = | 700.0 | nM | 374.5 | CC(C)CCC[C@@H](C)[C@H]1CCC2[C@@](C)(COP(=O)(O)O)CCC[C@@]21C | Homo sapiens | CHEMBL832081 | single protein format |
| CHEMBL337173 |  |
IC50 | = | 790.0 | nM | 321.76 | O=C1C(Cl)=C(NCCN2CCOCC2)C(=O)c2ncccc21 | Homo sapiens | CHEMBL2065477 | single protein format |
| CHEMBL1765355 |  |
IC50 | = | 800.0 | nM | 400.56 | C=C(C)CCC[C@]1(C)CCC[C@@H]2C1=CC[C@@H](C)[C@@]2(C)CC(=O)C1=CC(=O)O[C@H]1O | Homo sapiens | CHEMBL1767947 | single protein format |
| CHEMBL459929 |  |
IC50 | = | 820.0 | nM | 451.94 | Cc1ccc(-c2nnc(SCC(=O)c3ccc(O)c(O)c3)n2-c2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL1003158 | assay format |