P30291 | WEE1_HUMAN | Wee1-like protein kinase (WEE1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 299~568 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5278196 |  |
IC50 | = | 0.1 | nM | 471.61 | CCc1cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(C(C)(C)O)n1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5284925 |  |
IC50 | = | 0.2 | nM | 504.66 | CCc1cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(N=S(C)(C)=O)n1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5279054 |  |
IC50 | = | 0.42 | nM | 485.64 | CC(C)c1cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(C(C)(C)O)n1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5269524 |  |
IC50 | = | 0.51 | nM | 490.64 | Cc1cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(N=S(C)(C)=O)n1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5282382 |  |
IC50 | = | 0.51 | nM | 534.67 | CN1CCN(c2ccc(Nc3ncc4cc(C5CC5)n(-c5cccc(N=S(C)(C)=O)n5)c4n3)cc2F)CC1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5284989 |  |
IC50 | = | 0.57 | nM | 536.68 | CCCc1c(F)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(N=S(C)(C)=O)n1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5281278 |  |
IC50 | = | 0.6 | nM | 457.58 | Cc1cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(C(C)(C)O)n1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5290439 |  |
IC50 | = | 0.76 | nM | 518.69 | CCCc1cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(N=S(C)(C)=O)n1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5270034 |  |
IC50 | = | 0.86 | nM | 584.74 | CN1CCN(C2CCN(c3ccc(Nc4ncc5c(F)c(C6CC6)n(-c6cccc(C(C)(C)O)n6)c5n4)cc3)CC2)CC1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5273079 |  |
IC50 | = | 0.88 | nM | 485.64 | CCCc1cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(C(C)(C)O)n1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5289843 |  |
IC50 | = | 0.92 | nM | 516.68 | CN1CCN(c2ccc(Nc3ncc4cc(C5CC5)n(-c5cccc(N=S(C)(C)=O)n5)c4n3)cc2)CC1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5278751 |  |
IC50 | = | 0.96 | nM | 518.69 | CC(C)c1cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(N=S(C)(C)=O)n1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL4878479 |  |
IC50 | = | 1.0 | nM | 480.58 | CCn1c(=O)c2cnc(Nc3ccc4c(c3)CCNC4(C)C)nc2n1-c1cccc(C2(C#N)CC2)n1 | Homo sapiens | CHEMBL4807218 | assay format |
| CHEMBL4873514 |  |
IC50 | = | 1.0 | nM | 478.56 | CCn1c(=O)c2cnc(Nc3ccc4c(c3)CCNC43CC3)nc2n1-c1cccc(C2(C#N)CC2)n1 | Homo sapiens | CHEMBL4807218 | assay format |
| CHEMBL5199347 |  |
IC50 | = | 1.03 | nM | 551.74 | CN1CCC2(CC1)CCN(c1ccc(Nc3ncc4cc(C5CC5)n(-c5cccc(C(C)(C)O)n5)c4n3)cc1)CC2 | Homo sapiens | CHEMBL5127778 | assay format |
| CHEMBL5279737 |  |
IC50 | = | 1.33 | nM | 566.75 | CN1CCN(C2CCN(c3ccc(Nc4ncc5cc(C6CC6)n(-c6cccc(C(C)(C)O)n6)c5n4)cc3)CC2)CC1 | Homo sapiens | CHEMBL5224836 | single protein format |
| CHEMBL5285380 |  |
IC50 | = | 1.7 | nM | 473.58 | C=CCn1c(=O)c2cnc(Nc3ccc(CCN(C)C)cc3)nc2n1-c1cccc(C(C)(C)O)n1 | Homo sapiens | CHEMBL5230685 | single protein format |
| CHEMBL5197954 |  |
IC50 | = | 1.83 | nM | 526.65 | C=CCn1c(=O)c2cnc(Nc3ccc(N4C[C@H]5CN(C)C[C@H]5C4)cc3)nc2n1-c1ccc(C(C)(C)O)cn1 | Homo sapiens | CHEMBL5127764 | cell-based format |
| CHEMBL4867107 |  |
IC50 | = | 2.0 | nM | 495.41 | Cc1cn(-c2c(Cl)cccc2Cl)c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc12 | Homo sapiens | CHEMBL4844304 | single protein format |
| CHEMBL4861984 |  |
IC50 | = | 2.0 | nM | 459.53 | CCn1c(=O)c2cnc(Nc3ccc4c(c3)CNCC4)nc2n1-c1cccc(C2(CF)CC2)n1 | Homo sapiens | CHEMBL4807218 | assay format |