ProtHub

P29597 | TYK2_HUMAN | Non-receptor tyrosine-protein kinase TYK2 (TYK2)

Pfam Domain Table

Accession	Domain	Range
PF07714	PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase	590~866
PF07714	PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase	898~1167
PF17887	Jak1_Phl - Jak1 pleckstrin homology-like domain	285~432
PF18377	FERM_F2 - FERM F2 acyl-CoA binding protein-like domain	142~266
PF18379	FERM_F1 - FERM F1 ubiquitin-like domain	28~124
PF21990	SH2_1 - SH2 domain	450~553

3D structures mapped by conservation among orthologs

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 CSV Ki CSV

Only the first 20 rows are shown.

molecule_chembl_id	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL5427107	IC50	=	0.01	nM	440.48	[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)CC2CC2)cc1Nc1nccc(-c2ncn(C)n2)c1OC	Homo sapiens	CHEMBL5365708	single protein format
CHEMBL5427277	IC50	=	0.016	nM	383.43	CC(=O)Nc1cc(Nc2cccc(S(C)(=O)=O)n2)c(-c2ccccn2)cn1	Homo sapiens	CHEMBL5383674	single protein format
CHEMBL5422022	IC50	=	0.018	nM	457.51	COCCOc1cc(Nc2cc(NC(C)=O)ncc2-c2ccccn2)nc(S(C)(=O)=O)c1	Homo sapiens	CHEMBL5383674	single protein format
CHEMBL5418288	IC50	=	0.026	nM	499.55	COc1cc(Nc2cc(NC(C)=O)ncc2-c2ccc3c(n2)OCC(C)(C)O3)nc(S(C)(=O)=O)c1	Homo sapiens	CHEMBL5383674	single protein format
CHEMBL5416227	IC50	=	0.026	nM	431.45	COc1cc(Nc2cc(NC(C)=O)ncc2-c2ccc(F)cn2)nc(S(C)(=O)=O)c1	Homo sapiens	CHEMBL5383674	single protein format
CHEMBL5420349	IC50	=	0.027	nM	471.54	COc1cc(Nc2cc(NC(C)=O)ncc2-c2ccc(C(C)(C)O)cn2)nc(S(C)(=O)=O)c1	Homo sapiens	CHEMBL5383674	single protein format
CHEMBL5417355	IC50	=	0.038	nM	382.45	CC(=O)Nc1cc(Nc2cccc(S(C)(=O)=O)c2)c(-c2ccccn2)cn1	Homo sapiens	CHEMBL5383674	single protein format
CHEMBL5440225	IC50	=	0.05	nM	463.52	[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cc(C)c(C)cn2)cc1Nc1nccc(-c2ncn(C)n2)c1OC	Homo sapiens	CHEMBL5365708	single protein format
CHEMBL5437122	IC50	=	0.05	nM	449.49	[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cc(C)ccn2)cc1Nc1nccc(-c2ncn(C)n2)c1OC	Homo sapiens	CHEMBL5365708	single protein format
CHEMBL5412034	IC50	=	0.06	nM	453.46	[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(F)cn2)cc1Nc1nccc(-c2ncn(C)n2)c1OC	Homo sapiens	CHEMBL5365708	single protein format
CHEMBL5420928	IC50	<	0.06	nM	412.4	NC(=O)c1nnc(-c2c(F)cccc2F)cc1Nc1ccc(N2CCOCC2)cn1	Homo sapiens	CHEMBL5383631	single protein format
CHEMBL5418485	IC50	=	0.07	nM	465.49	[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cc(OC)ccn2)cc1Nc1nccc(-c2ncn(C)n2)c1OC	Homo sapiens	CHEMBL5365708	single protein format
CHEMBL5413544	IC50	=	0.08	nM	426.46	[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1nccc(-c2ncn(C)n2)c1OC	Homo sapiens	CHEMBL5365708	single protein format
CHEMBL5413489	IC50	=	0.08	nM	426.38	NC(=O)c1nnc(-c2c(F)cccc2F)cc1Nc1ccc(N2CCOCC2=O)cn1	Homo sapiens	CHEMBL5383631	single protein format
CHEMBL5439728	IC50	=	0.09	nM	449.49	[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cccc(C)n2)cc1Nc1nccc(-c2ncn(C)n2)c1OC	Homo sapiens	CHEMBL5365708	single protein format
CHEMBL5396654	IC50	=	0.1	nM	465.47	[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cnc(C)cn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC	Homo sapiens	CHEMBL5365708	single protein format
CHEMBL5411149	IC50	=	0.1	nM	507.55	[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(C(C)(C)N)cn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC	Homo sapiens	CHEMBL5365708	single protein format
CHEMBL5437552	IC50	=	0.1	nM	508.53	[2H]C([2H])([2H])NC(=O)c1nnc(Nc2ccc(C(C)(C)O)cn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC	Homo sapiens	CHEMBL5365708	single protein format
CHEMBL5411146	IC50	=	0.1	nM	422.46	[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1nccc(-c2ccccn2)c1OC	Homo sapiens	CHEMBL5365708	single protein format
CHEMBL5416323	IC50	=	0.1	nM	468.44	[2H]C([2H])([2H])NC(=O)c1nnc(Nc2cc(F)ccn2)cc1Nc1nccc(-c2ncc(F)cn2)c1OC	Homo sapiens	CHEMBL5365708	single protein format

Pfam Domain Table

[ Domain: "PH domain-like" // FERM_C_TYK2 ]

[ Domain: "Acyl-CoA binding protein-like" // B41_C ]

[ Domain: "SH2" // SH2_1 ]

[ Domain: "Ubiquitin-like" // B41_N ]

[ Domain: "Protein kinase" // Pkinase_Tyr ]