P29475 | NOS1_HUMAN | Nitric oxide synthase, brain (NOS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00175 | NAD_binding_1 - Oxidoreductase NAD-binding domain | 1251~1363 | |
| PF00258 | Flavodoxin_1 - Flavodoxin | 762~935 | |
| PF00595 | PDZ - PDZ domain | 18~94 | |
| PF00667 | FAD_binding_1 - FAD binding domain | 991~1219 | |
| PF02898 | NO_synthase - Nitric oxide synthase, oxygenase domain | 357~717 |
3D structures mapped by conservation among orthologs
[ Domain: "Nitric oxide (NO) synthase oxygenase domain" // NO_synthase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL106871 |  |
IC50 | = | 1.0 | nM | 219.31 | CCSC(=N)NCCC[C@H](N)C(=O)O | Homo sapiens | CHEMBL5360719 | single protein format |
| CHEMBL302657 |  |
IC50 | = | 10.0 | nM | 150.22 | CCCc1cc(C)cc(N)n1 | Homo sapiens | CHEMBL751656 | single protein format |
| CHEMBL1944717 |  |
IC50 | = | 12.0 | nM | 398.8 | O=c1cc(CN(c2cccc(Cl)c2)c2cnccn2)c2ccc(F)c(F)c2[nH]1 | Homo sapiens | CHEMBL1948399 | cell-based format |
| CHEMBL3675250 |  |
IC50 | = | 14.0 | nM | 360.55 | CN(C)CCCN1CCSc2cc(/N=C(\N)c3cccs3)ccc21 | Homo sapiens | CHEMBL3705909 | single protein format |
| CHEMBL3216307 |  |
IC50 | = | 20.0 | nM | 425.43 | CN1CCC[C@H]1CCn1ccc2cc(NC(=N)c3cccs3)ccc21.Cl.Cl | Homo sapiens | CHEMBL1825585 | cell-based format |
| CHEMBL3639741 |  |
IC50 | = | 28.0 | nM | 346.53 | CNCCCN1CCSc2cc(/N=C(\N)c3cccs3)ccc21 | Homo sapiens | CHEMBL3705909 | single protein format |
| CHEMBL397446 |  |
IC50 | = | 30.0 | nM | 385.56 | CN1CCCC1CCNc1nc2cc(NC(=N)c3cccs3)ccc2s1 | Homo sapiens | CHEMBL892679 | single protein format |
| CHEMBL191242 |  |
IC50 | = | 31.0 | nM | 152.24 | C[C@@H]1CC(N)=N[C@@H]2CCC[C@H]12 | Homo sapiens | CHEMBL833057 | single protein format |
| CHEMBL3675244 |  |
IC50 | = | 34.0 | nM | 362.52 | N/C(=N\c1ccc2c(c1)SCCN2CCNCCO)c1cccs1 | Homo sapiens | CHEMBL3705909 | single protein format |
| CHEMBL2333953 |  |
IC50 | = | 35.0 | nM | 383.95 | N=C(Nc1ccc(CCNCCc2cccc(Cl)c2)cc1)c1cccs1 | Homo sapiens | CHEMBL2343335 | single protein format |
| CHEMBL293212 |  |
IC50 | = | 35.0 | nM | 369.92 | N=C(Nc1ccc(CCNCc2cccc(Cl)c2)cc1)c1cccs1 | Homo sapiens | CHEMBL841529 | single protein format |
| CHEMBL433589 |  |
IC50 | = | 36.0 | nM | 152.24 | C[C@H]1CC(N)=N[C@H]2CCC[C@H]21 | Homo sapiens | CHEMBL833057 | single protein format |
| CHEMBL419740 |  |
IC50 | = | 40.0 | nM | 163.22 | CC(=N)Nc1cccc(CN)c1 | Homo sapiens | CHEMBL2343335 | single protein format |
| CHEMBL3216124 |  |
IC50 | = | 40.0 | nM | 387.38 | CN(C)CCN1CCc2cc(NC(=N)c3cccs3)ccc21.Cl.Cl | Homo sapiens | CHEMBL2209794 | cell-based format |
| CHEMBL162416 |  |
IC50 | = | 42.0 | nM | 367.92 | NC1=Nc2cc(CCCNCc3cccc(Cl)c3)ccc2[C@H]2CCC[C@@H]12 | Homo sapiens | CHEMBL750244 | single protein format |
| CHEMBL545441 |  |
IC50 | = | 42.0 | nM | 440.85 | Cl.Cl.NC1=Nc2cc(CCCNCc3cccc(Cl)c3)ccc2[C@H]2CCC[C@@H]12 | Homo sapiens | CHEMBL841529 | single protein format |
| CHEMBL1944884 |  |
IC50 | = | 46.0 | nM | 392.41 | Cc1ccccc1CN(Cc1cc(=O)[nH]c2c(F)c(F)ccc12)c1cnccn1 | Homo sapiens | CHEMBL1948399 | cell-based format |
| CHEMBL542132 |  |
IC50 | = | 48.0 | nM | 426.82 | Cl.Cl.NC1=Nc2cc(CCNCc3cccc(Cl)c3)ccc2[C@H]2CCC[C@@H]12 | Homo sapiens | CHEMBL841529 | single protein format |
| CHEMBL3675251 |  |
IC50 | = | 50.0 | nM | 346.53 | CCNCCN1CCSc2ccc(/N=C(\N)c3cccs3)cc21 | Homo sapiens | CHEMBL3705909 | single protein format |
| CHEMBL1221703 |  |
IC50 | = | 50.0 | nM | 210.3 | CCC[C@@H]1COc2ccsc2C(N)=N1 | Homo sapiens | CHEMBL1227494 | single protein format |