P29474 | NOS3_HUMAN | Nitric oxide synthase, endothelial (NOS3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00175 | NAD_binding_1 - Oxidoreductase NAD-binding domain | 1011~1123 | |
| PF00258 | Flavodoxin_1 - Flavodoxin | 522~698 | |
| PF00667 | FAD_binding_1 - FAD binding domain | 752~979 | |
| PF02898 | NO_synthase - Nitric oxide synthase, oxygenase domain | 121~481 |
3D structures mapped by conservation among orthologs
[ Domain: "Nitric oxide (NO) synthase oxygenase domain" // NO_synthase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL294084 |  |
IC50 | = | 49.0 | nM | 136.2 | CCc1cc(C)cc(N)n1 | Homo sapiens | CHEMBL676782 | single protein format |
| CHEMBL302657 |  |
IC50 | = | 50.0 | nM | 150.22 | CCCc1cc(C)cc(N)n1 | Homo sapiens | CHEMBL678077 | single protein format |
| CHEMBL1221702 |  |
IC50 | = | 80.0 | nM | 182.25 | C[C@H]1CN=C(N)c2sccc2O1 | Homo sapiens | CHEMBL1227493 | single protein format |
| CHEMBL61427 |  |
IC50 | = | 81.0 | nM | 123.16 | Cc1ccnc(N)c1N | Homo sapiens | CHEMBL676782 | single protein format |
| CHEMBL61939 |  |
IC50 | = | 150.0 | nM | 122.17 | Cc1ccnc(N)c1C | Homo sapiens | CHEMBL676782 | single protein format |
| CHEMBL294609 |  |
IC50 | = | 150.0 | nM | 164.25 | Cc1cc(N)nc(CC(C)C)c1 | Homo sapiens | CHEMBL676782 | single protein format |
| CHEMBL59925 |  |
IC50 | = | 170.0 | nM | 122.17 | Cc1cc(C)nc(N)c1 | Homo sapiens | CHEMBL678077 | single protein format |
| CHEMBL272708 |  |
IC50 | = | 180.0 | nM | 297.79 | CN1CCC(N(C)Cc2cc(Cl)ccc2[N+](=O)[O-])CC1 | Homo sapiens | CHEMBL946888 | cell-based format |
| CHEMBL354788 |  |
IC50 | = | 180.0 | nM | 249.22 | NC1=NC(c2ccco2)Nc2c(F)ccc(F)c21 | Homo sapiens | CHEMBL873599 | single protein format |
| CHEMBL299677 |  |
IC50 | = | 200.0 | nM | 150.22 | Cc1cc(N)nc(C(C)C)c1 | Homo sapiens | CHEMBL676782 | single protein format |
| CHEMBL1230023 |  |
IC50 | = | 200.0 | nM | 210.3 | CCC[C@H]1COc2ccsc2C(=N)N1 | Homo sapiens | CHEMBL2155041 | single protein format |
| CHEMBL1221703 |  |
IC50 | = | 200.0 | nM | 210.3 | CCC[C@@H]1COc2ccsc2C(N)=N1 | Homo sapiens | CHEMBL1227493 | single protein format |
| CHEMBL6808 |  |
IC50 | = | 220.0 | nM | 112.18 | CC1CCN=C(N)C1 | Homo sapiens | CHEMBL676782 | single protein format |
| CHEMBL428069 |  |
IC50 | = | 220.0 | nM | 367.92 | CN(Cc1cc(Cl)ccc1C#N)C1CCN(CCc2ccccc2)CC1 | Homo sapiens | CHEMBL946888 | cell-based format |
| CHEMBL75304 |  |
IC50 | = | 230.0 | nM | 110.16 | CC1=CC(N)=NCC1 | Homo sapiens | CHEMBL675569 | cell-based format |
| CHEMBL62077 |  |
IC50 | = | 230.0 | nM | 122.17 | CCc1ccnc(N)c1 | Homo sapiens | CHEMBL676782 | single protein format |
| CHEMBL74919 |  |
IC50 | = | 240.0 | nM | 124.19 | CC1=CC(N)=NC(C)C1 | Homo sapiens | CHEMBL675569 | cell-based format |
| CHEMBL1783094 |  |
IC50 | = | 250.0 | nM | 99.14 | N=C(N)[C@H]1CCN1 | Homo sapiens | CHEMBL1786327 | single protein format |
| CHEMBL269076 |  |
IC50 | = | 300.0 | nM | 126.2 | CC1CC(N)=NC(C)C1 | Homo sapiens | CHEMBL678078 | single protein format |
| CHEMBL40833 |  |
IC50 | = | 300.0 | nM | 108.14 | Cc1ccnc(N)c1 | Homo sapiens | CHEMBL678077 | single protein format |